Dementia associated with Parkinson’s disease: Applying the Movement Disorder Society Task Force criteria

Martinez‐Martín, Pablo; Falup‐Pecurariu, Cristian; Rodríguez‐Blázquez, Carmen; Serrano‐Dueñas, Marcos; Artal, Francisco Javier Carod; Abuin, J.M. Rojo; Aarsland, Dag

doi:10.1016/j.parkreldis.2011.05.017

Cited by 63 publications

(59 citation statements)

References 26 publications

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“…Interestingly, the correlation between caregivers' burden and psychotic symptoms was higher in PD patients with dementia than in those with normal cognition. PD patients with dementia have a greater prevalence of psychotic symptoms than patients without dementia, as hypothesized in this study, and this fact increases caregiver burden [23,24]. Different profiles of NPS according to cognitive status were observed in this study: while PD patients with normal cognitive function had more depression and anxiety, PD patients with dementia showed higher percentages of apathy/lack of initiative and mental fatigue.…”

Section: Discussionmentioning

confidence: 52%

Neuropsychiatric symptoms and caregiver's burden in Parkinson's disease

Martinez‐Martín

Rodríguez‐Blázquez

Forjaz

et al. 2015

Parkinsonism & Related Disorders

190

166

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Introduction: In Parkinson's disease (PD), neuropsychiatric symptoms (NPS) can be particularly burdensome for caregivers. The main goal of this study was to assess the impact of NPS, assessed by means of a new specific scale, on caregiver burden.Methods: A sample of 584 pairs of PD patients and their primary caregivers was studied. Patients' NPS were measured with the Scale for Evaluation of Neuropsychiatric Disorders in PD (SEND-PD), and the Zarit Caregiver Burden Inventory was used to quantify caregiver burden. Three linear regression models were built to check factors associated with caregiver burden, one for the total sample and two for subgroups stratified by the presence of dementia. Results: The most prevalent SEND-PD dimensions were mood/apathy (87.4%), followed by psychotic symptoms (48.5%) and impulse control disorders (26.5%). Patients with dementia (n=94; 16.15% of sample) consistently presented more NPS than patients without dementia (p<0.001). On linear regression models, the main determinants of caregiver burden (for the total sample and the sample of patients without dementia) were SEND-PD dimensions mood/apathy and psychosis, PD-related disability and disease duration. For patients with dementia, the only significant caregiver burden determinants were SEND-PD psychosis and mood/apathy subscale scores.Conclusions: NPS in PD are highly associated with and are determinants of caregiver burden, and are more prevalent and burdensome in patients with dementia. Detailed assessment and specific interventions aimed at NPS could alleviate caregiver burden. Author DeclarationParkinsonism & Related Disorders is committed to proper scientific conduct and the protection of animal and human research subjects. Submission of this manuscript implies compliance with the following ethical requirements. Please affirm that you are representing all of the authors in stating compliance with these policies by checking the box at the end of this section.1. Studies with human subjects must have been conducted in accordance with the Declaration of Helsinki. All persons must have provided informed consent prior to being included in the study.2. Studies with animal subjects must have been conducted in accordance with the Guide for the Care and Use of Laboratory Subjects as adopted by the US National Institutes of Health and/or according to the requirements of all applicable local, national and international standards.3. Protocols with animal or human subjects must have been approved by the relevant local committee(s) charged with ensuring subject protection. Studies that entail pain or distress will be assessed in terms of the balance between the distress inflicted and the likelihood of benefit.4. The authors declare that the manuscript is original, that it is not being considered for publication elsewhere, and that it will not be submitted elsewhere while still under consideration for Parkinsonism & Related Disorders or after it has been accepted by Parkinsonism & Related Disorders.5. All authors have seen and app...

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Section: Discussionmentioning

confidence: 52%

Neuropsychiatric symptoms and caregiver's burden in Parkinson's disease

Martinez‐Martín

Rodríguez‐Blázquez

Forjaz

et al. 2015

Parkinsonism & Related Disorders

190

166

View full text Add to dashboard Cite

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“…Hitherto clinicians had often used generic criteria such as the Diagnostic and Statistical Manual of Mental Disorders to diagnose PDD 21. A diagnosis of PDD requires a confirmed diagnosis of PD as outlined by the UK Parkinson's Disease Brain Bank Criteria22 and the development of a dementia syndrome in the context of established PD 20.…”

Section: Diagnosismentioning

confidence: 99%

Cognitive impairment in Parkinson's disease

Cosgrove

Alty

Jamieson

2015

Postgraduate Medical Journal

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Cognitive impairment is a significant non-motor symptom of Parkinson's disease (PD). Longitudinal cohort studies have demonstrated that approximately 50% of those with PD develop dementia after 10 years, increasing to over 80% after 20 years. Deficits in cognition can be identified at the time of PD diagnosis in some patients and this mild cognitive impairment (PD-MCI) has been studied extensively over the last decade. Although PD-MCI is a risk factor for developing Parkinson's disease dementia there is evidence to suggest that PD-MCI might consist of distinct subtypes with different pathophysiologies and prognoses. The major pathological correlate of Parkinson's disease dementia is Lewy body deposition in the limbic system and neocortex although Alzheimer's related pathology is also an important contributor. Pathological damage causes alteration to neurotransmitter systems within the brain, producing behavioural change. Management of cognitive impairment in PD requires a multidisciplinary approach and accurate communication with patients and relatives is essential.

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“…31 Montreal Cognitive Assessment, a brief and potentially useful tool developed to assess a broader range of domains frequently affected in PD, is more sensitive than the commonly used MMSE in cognitive impairment, especially in the screening of mild cognitive impairment. 32 Executive function, language abilities, and visuospatial processing can be more rigorously assessed with MoCA than MMSE in patients with PD. 33 After having investigated the validity of the MoCA and MMSE in the detection of cognitive impairment in PD, Hoops et al suggested that additional assessment was necessary for a positive screening.…”

Section: Discussionmentioning

confidence: 99%

Validation of Neuropsychological Tests to Screen for Dementia in Chinese Patients With Parkinson’s Disease

Qiao

Wang

et al. 2015

Am J Alzheimers Dis Other Demen

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To compare the accuracy of different neuropsychological tests and their combinations for deriving reliable cognitive indices for dementia diagnosis in Parkinson's disease (PD). One hundred forty consecutive patients with PD were recruited and administrated an extensive battery of neuropsychological tests. Discriminant analysis and receiver-operator characteristic curve were used to evaluate their correct classifications and validity. Patients with PD having dementia (PDD; 23.5%) performed significantly worse in all tests than patients without dementia. Age of onset, disease duration, Hoehn-Yahr grade, Unified Parkinson's Disease Rating Scale part III scores, and education were associated with dementia in patients with PD. Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment, and Block Design (BD) showed better specificity and sensitivity when used alone, and combined use of MMSE and BD further increased the validity. Our results indicated that the accuracy of MMSE was better in dementia diagnosis of Chinese patients with PD, and combined use of MMSE and BD could further increase the validity of dementia diagnosis.

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Dementia associated with Parkinson’s disease: Applying the Movement Disorder Society Task Force criteria

Cited by 63 publications

References 26 publications

Neuropsychiatric symptoms and caregiver's burden in Parkinson's disease

Neuropsychiatric symptoms and caregiver's burden in Parkinson's disease

Cognitive impairment in Parkinson's disease

Validation of Neuropsychological Tests to Screen for Dementia in Chinese Patients With Parkinson’s Disease

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