Dementia in Latin America: An Emergent Silent Tsunami

Báez, Sandra; Ibáñez, Agustín

doi:10.3389/fnagi.2016.00253

Cited by 38 publications

(50 citation statements)

References 35 publications

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“…LAC offer access to unique populations (genetic clusters, low literacy, multilingual, multiethnic). 36 This region hosts the world's largest populations of familial AD (Colombia), Huntington disease (Venezuela), and ataxia (Cuba), alongside multiple novel and rare functional genomic variants of other diseases. For instance, the Caribbean has a high late-onset dementia incidence, and genetic studies have shown large effect sizes.…”

Section: Capitalizing On Unique Populationsmentioning

confidence: 99%

Dementia in Latin America

et al. 2018

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The demographic structure of Latin American countries (LAC) is fast approaching that of developing countries, and the predicted prevalence of dementia in the former already exceeds the latter. Dementia has been declared a global challenge, yet regions around the world show differences in both the nature and magnitude of such a challenge. This article provides evidence and insights on barriers which, if overcome, would enable the harmonization of strategies to tackle the dementia challenge in LAC. First, we analyze the lack of available epidemiologic data, the need for standardizing clinical practice and improving physician training, and the existing barriers regarding resources, culture, and stigmas. We discuss how these are preventing timely care and research. Regarding specific health actions, most LAC have minimal mental health facilities and do not have specific mental health policies or budgets specific to dementia. In addition, local regulations may need to consider the regional context when developing treatment and prevention strategies. The support needed nationally and internationally to enable a smooth and timely transition of LAC to a position that integrates global strategies is highlighted. We focus on shared issues of poverty, cultural barriers, and socioeconomic vulnerability. We identify avenues for collaboration aimed to study unique populations, improve valid assessment methods, and generate opportunities for translational research, thus establishing a regional network. The issues identified here point to future specific actions aimed at tackling the dementia challenge in LAC.

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Section: Capitalizing On Unique Populationsmentioning

confidence: 99%

Dementia in Latin America

et al. 2018

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“…L a demencia constituye un serio problema de salud pública mundial, debido a los elevados costos económicos, sociales y al progresivo envejecimiento poblacional especialmente en Latinoamérica (LA) 1 , donde el número de pobladores con demencia se incrementará de 7,8 millones en 2013 a más de 27 millones en el 2050 2 . Alzheimer´s Disease International (ADI) reportó una prevalencia global de demencia en LA de 8,4% en mayores de 60 años de edad 3 , mientras que la tasa global de demencia de ocho estudios latinoamericanos realizados en pobladores mayores de 65 años de edad, viviendo en comunidad, fue de 7,1% 4 .…”

Section: Introductionunclassified

Nivel de conocimientos sobre demencia frontotemporal en una muestra de médicos que evalúan regularmente a pacientes con demencia en Lima-Perú

Custodio

Becerra-Becerra

Cruzado

et al. 2018

Rev. chil. neuro-psiquiatr.

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Physicians with specialty in geriatrics, psychiatry and neurology have not received training about the differential diagnosis of dementia, particularly regarding fronto-temporal dementia (FTD). Objective: To assess the level of knowledge of physicians about FTD. Material and Method: The survey was carried out during symposiums and scientific congresses from January 2016 to July 2017. Inclusion criteria: being a general practitioner or specialist in Geriatrics, Neurology and psychiatry whose training process as a physician and specialist has been carried out in Peruvian universities. We analyzed 217 surveys of which 13 were eliminated. The survey was divided into three parts, the first about general data of doctors, the second part was about the diagnosis of dementia; and the third on specific data of FTD. STATA version 12 was used for the statistical analysis. Results: 90% of the doctors surveyed were specialists in: Psychiatry (41.3%), Geriatrics artículo de investigación Recibido: 14/01/2017 Aceptado: 28/03/2018 Los autores no presentan ningún tipo de conflicto de interés. Financiamiento: El trabajo fue financiado por los autores.

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“…These same factors, in combination with a generally docile temper, relatively small size as well as ease of breeding and maintenance, make this species a potentially ideal laboratory model for social-affective behavioural and neuroscience research (Colonnello et al, 2011). In humans, social factors such as perceived social loneliness, social stress and adverse sociocultural factors can increase (Baez & Ibanez, 2016;Ibanez, Kuljis, Matallana, & Manes, 2014;Parra et al, 2018) and even double the risk of dementia (Holwerda et al, 2014).…”

Section: Cognitive and Behavioural Dysfunction In The Degumentioning

confidence: 99%

The long-lived Octodon degus as a rodent drug discovery model for Alzheimer's and other age-related diseases

Hurley

Deacon

Beyer

et al. 2018

Pharmacology & Therapeutics

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Alzheimer's disease (AD) is a multifactorial progressive neurodegenerative disease. Despite decades of research, no disease modifying therapy is available and a change of research objectives and/or development of novel research tools may be required. Much AD research has been based on experimental models using animals with a short lifespan that have been extensively genetically manipulated and do not represent the full spectrum of late-onset AD, which make up the majority of cases. The aetiology of AD is heterogeneous and involves multiple factors associated with the late-onset of the disease like disturbances in brain insulin, oxidative stress, neuroinflammation, metabolic syndrome, retinal degeneration and sleep disturbances which are all progressive abnormalities that could account for many molecular, biochemical and histopathological lesions found in brain from patients dying from AD. This review is based on the long-lived rodent Octodon degus (degu) which is a small diurnal rodent native to South America that can spontaneously develop cognitive decline with concomitant phospho-tau, β-amyloid pathology and neuroinflammation in brain. In addition, the degu can also develop several other conditions like type 2 diabetes, macular and retinal degeneration and atherosclerosis, conditions that are often associated with aging and are often comorbid with AD. Long-lived animals like the degu may provide a more realistic model to study late onset AD.

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Dementia in Latin America: An Emergent Silent Tsunami

Cited by 38 publications

References 35 publications

Dementia in Latin America

Dementia in Latin America

Nivel de conocimientos sobre demencia frontotemporal en una muestra de médicos que evalúan regularmente a pacientes con demencia en Lima-Perú

The long-lived Octodon degus as a rodent drug discovery model for Alzheimer's and other age-related diseases

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