Dementia in schizophrenia

Radhakrishnan, Raghavakurup; Butler, Robert W.; Head, Laura

doi:10.1192/apt.bp.110.008268

Cited by 4 publications

(4 citation statements)

References 53 publications

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“…Some life-threatening concomitant diseases may put ADRD as of secondary importance, such as cardiac insufficiency. Other comorbidities, such as chronic psychotic disorders (schizophrenia for example), may involve symptoms which may represent barriers to ADRD management or identification [ 38 , 39 ]. In the 65–74 and 75–84 years groups, antipsychotic dispensing preceding ADRD identification decreased the probability of future favorable HUTs, as well the addition of anxiolytic dispensing in the 65–74 years group.…”

Section: Discussionmentioning

confidence: 99%

Which factors preceding dementia identification impact future healthcare use trajectories: multilevel analyses in administrative data

Couret,

Lapeyre-Mestre,

Gombault-Datzenko

et al. 2024

BMC Geriatr

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Background Healthcare use patterns preceding a diagnosis of Alzheimer’s Disease and Related Diseases (ADRD) may be associated with the quality of healthcare use trajectories (HUTs) after diagnosis. We aimed to identify determinants of future favorable HUTs, notably healthcare use preceding ADRD identification. Methods This nationwide retrospective observational study was conducted on subjects with incident ADRD identified in 2012 in the French health insurance database. We studied the 12-month healthcare use ranging between 18 and 6 months preceding ADRD identification. The five-year HUTs after ADRD identification were qualified by experts as favorable or not. In order to take into account geographical differences in healthcare supply, we performed mixed random effects multilevel multivariable logistic regression model to identify determinants of future favorable HUTs. Analyses were stratified by age group (65–74, 75–84, ≥ 85). Results Being a woman, and preventive and specialist care preceding ADRD identification increased the probability of future favorable HUT, whereas institutionalization, comorbidities, medical transportation and no reimbursed drug during [-18;-6] months decreased it. Besides, some specificities appeared according to age groups. Among the 65–74 years subjects, anxiolytic dispensing preceding ADRD identification decreased the probability of future favorable HUT. In the 75–84 years group, unplanned hospitalization and emergency room visit preceding ADRD identification decreased this probability. Among subjects aged 85 and older, short hospitalization preceding ADRD identification increased the probability of future favorable HUTs. Conclusion Regular healthcare use with preventive and specialist care preceding ADRD identification increased the probability of future favorable HUTs whereas dependency decreased it.

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Section: Discussionmentioning

confidence: 99%

Which factors preceding dementia identification impact future healthcare use trajectories: multilevel analyses in administrative data

Couret,

Lapeyre-Mestre,

Gombault-Datzenko

et al. 2024

BMC Geriatr

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“…Alzheimer's disease and related dementias are chronic, progressive disorders that result in the impairment of cognitive functions, including memory, orientation, comprehension, and executive function [1] – [3] . The debilitating and disorientating nature of dementia, coupled with the older age of the prevalent population, results in a substantial proportion of individuals with dementia becoming institutionalized in long-term care (LTC) facilities [4] – [6] .…”

Section: Introductionmentioning

confidence: 99%

“…The debilitating and disorientating nature of dementia, coupled with the older age of the prevalent population, results in a substantial proportion of individuals with dementia becoming institutionalized in long-term care (LTC) facilities [4] – [6] . In addition to the impact of cognitive impairment, the accompanying responsive behaviours that may occur [7] , also known as behavioural and psychological symptoms of dementia (BPSD), add additional challenges for patients, families, caregivers and staff of LTC facilities [1] , [2] .…”

Section: Introductionmentioning

confidence: 99%

Effective Use of the Built Environment to Manage Behavioural and Psychological Symptoms of Dementia: A Systematic Review

et al. 2014

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ObjectiveTo determine the effectiveness of built environment interventions in managing behavioural and psychological symptoms of dementia (BPSD) among residents in long-term care settings.MethodsSystematic review of literature published from 1995–2013. Studies were included if they: were randomized controlled trials, quasi-experimental trials, or comparative cohort studies; were in long-term or specialized dementia care; included residents with dementia and BPSD; and examined effectiveness of a built environment intervention on frequency and/or severity of BPSD. Quality of included studies was assessed using the Downs and Black Checklist. Study design, patient population, intervention, and outcomes were extracted and narratively synthesized.ResultsFive low to moderate quality studies were included. Three categories of interventions were identified: change/redesign of existing physical space, addition of physical objects to environment, and type of living environment. One of the two studies that examined change/redesign of physical spaces reported improvements in BPSD. The addition of physical objects to an existing environment (n = 1) resulted in no difference in BPSD between treatment and control groups. The two studies that examined relocation to a novel living environment reported decreased or no difference in the severity and/or frequency of BPSD post-intervention. No studies reported worsening of BPSD following a built environment intervention.ConclusionsThe range of built environment interventions is broad, as is the complex and multi-dimensional nature of BPSD. There is inconclusive evidence to suggest a built environment intervention which is clinically superior in long-term care settings. Further high-quality methodological and experimental studies are required to demonstrate the feasibility and effectiveness of such interventions.

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“…Already present from the onset of the illness, cognitive impairment is stable for the first months/years of it, but the illness may develop differentially in different groups (Napal et al, 2012). Other studies suggest, with some contradictory data, initial stability and a drop in cognitive performance in schizophrenia beginning at 65 years of age (Friedman et al, 2001; Kurtz, 2005; Radhakrishnan, Butler, & Head, 2012); other authors specify (Rajii & Muslant, 2008) that this decline affects visuospatial activities first. McGorry et al (2014), applying the clinical staging model in his review of scientific findings about cognitive markers, maintains that the pattern and magnitude of impairment respondents exhibit in their first schizophrenic episodes are similar to those reported in meta-analyses of elderly patients with more chronic problems.…”

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confidence: 99%

Longitudinal Study of Cognitive Variables in Women with Schizophrenia: 31-Year Follow-Up Study

et al. 2015

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Dementia in schizophrenia

Cited by 4 publications

References 53 publications

Which factors preceding dementia identification impact future healthcare use trajectories: multilevel analyses in administrative data

Which factors preceding dementia identification impact future healthcare use trajectories: multilevel analyses in administrative data

Effective Use of the Built Environment to Manage Behavioural and Psychological Symptoms of Dementia: A Systematic Review

Longitudinal Study of Cognitive Variables in Women with Schizophrenia: 31-Year Follow-Up Study

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