Dementia in Subjects Aged 75 Years or Over within the PAQUID Cohort: Prevalence and Burden by Severity

Helmer, Catherine; Pérès, Karine; Letenneur, Luc; Guttiérez-Robledo, Luis Miguel; Ramaroson, Hanta; Barberger‐Gateau, Pascale; Fabrigoule, Colette; Orgogozo, Jean‐Marc; Dartigues, Jean‐François

doi:10.1159/000093459

Cited by 91 publications

(48 citation statements)

References 60 publications

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“…The EURODEM study reported an age-standardized prevalence of dementia of 6.4% [3]. For France, prevalence rates vary between 9.2% for elderly subjects >70 years and 17.8% for those >75 years of age [4,5,6]. Recently published projections show that the number of individuals suffering from Alzheimer dementia in the USA will nearly triple between 2010 and 2050 [7].…”

Section: Introductionmentioning

confidence: 99%

The French National Alzheimer Database: A Fast Growing Database for Researchers and Clinicians

Anthony¹,

Pradier²,

Chevrier³

et al. 2014

Dement Geriatr Cogn Disord

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Background: Alzheimer's disease (AD) is a major public health issue. The French National Alzheimer database (BNA) registers all medical acts performed by memory units and independent specialists throughout France. This article describes the national coverage, the registered patient characteristics and illustrates research possibilities. Methods: All data transmitted up to December 2012 were analyzed. The following patient characteristics were studied: age, sex, educational level, place of living, diagnosis, Mini-Mental State Examination score and existence of pharmacological or psychosocial interventions. Results: At the end of 2012, the BNA included 84% (n = 357) of all French memory units, contained 341,498 patients and more than 800,000 medical acts. AD accounted for 26.4% of all registered diagnoses, related disorders for 21.7% and mild cognitive impairment for 8.7%. Conclusion: The BNA offers a multitude of research possibilities. In the coming years, the BNA will play a major role in monitoring trends and related risk factors in AD.

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Section: Introductionmentioning

confidence: 99%

The French National Alzheimer Database: A Fast Growing Database for Researchers and Clinicians

Anthony¹,

Pradier²,

Chevrier³

et al. 2014

Dement Geriatr Cogn Disord

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“…Among these cases, two thirds live in low-income and middle-income countries [1]. Almost half of community-dwelling patients and 59.6% of institutionalized residents with dementia are in moderate or severe stages of this disease [2]. …”

Section: Introductionmentioning

confidence: 99%

A Useful and Brief Cognitive Assessment for Advanced Dementia in a Population with Low Levels of Education

Sales

Suemoto²,

Nitrini³

et al. 2011

Dement Geriatr Cogn Disord

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Background/Aims: Almost half of community-dwelling patients and 59.6% of institutionalized residents with dementia are in moderate or severe stages of this disease. The Mini-Mental State Examination (MMSE) has limited applicability to these patients due to floor effects. We aimed to determine the correlation between the MMSE and the Severe Mini-Mental State Examination (SMMSE), as well as SMMSE association with functional scales in patients having moderate to severe dementia and low levels of education. Methods: A cross-sectional study of patients 60 years or older attending an outpatient clinic was conducted. The MMSE, SMMSE and functional scales were applied. Clinical and demographic data from medical records were reviewed. Results: Seventy-five patients with a mean of 4.1 ± 3.6 years of education were analyzed. The mean scores on the MMSE and SMMSE were 7.8 ± 7.0 and 17.8 ± 9.4, respectively. The results indicated that the MMSE and SMMSE correlated only in patients who had an MMSE score of less than 10 (r = 0.87; p < 0.001). In addition, significant correlations were found between the SMMSE and functional scales (p < 0.001). It was observed that educational level did not interact with SMMSE performance. Conclusion: The SMMSE is a useful and reliable tool for a brief cognitive assessment of advanced dementia patients with low educational levels.

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“…Based on the PAQUID cohort study of 1461 subjects aged 75 years or over, the prevalence of dementia was estimated to be 17.8% of this population and Alzheimer's disease was the main etiology of dementia (79.6 per cent) 1.…”

Section: Introductionmentioning

confidence: 99%

A transient awakening of a patient with Alzheimer's disease that questions our practice

Bloch

2016

Clinical Case Reports

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Key Clinical MessageImprovements are not usually described in the natural history of degenerative dementia. It seems possible to find the normal workings of impaired learning and lost long‐term memories that appeared to be permanently altered after severe neurodegeneration and synaptic loss. The activation of these programs seems to represent the basis of the dysfunction, rather than the program itself.

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Dementia in Subjects Aged 75 Years or Over within the PAQUID Cohort: Prevalence and Burden by Severity

Cited by 91 publications

References 60 publications

The French National Alzheimer Database: A Fast Growing Database for Researchers and Clinicians

The French National Alzheimer Database: A Fast Growing Database for Researchers and Clinicians

A Useful and Brief Cognitive Assessment for Advanced Dementia in a Population with Low Levels of Education

A transient awakening of a patient with Alzheimer's disease that questions our practice

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