Dementia of frontal lobe type in monozygotic twins

Hodgson, R. E.; Barrett, Ken; Crook, Richard

doi:10.1002/gps.930080511

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…Standard clinical EEG is typically normal in FLD [9,46] and also in Pick's disease [19,20], even though several reports have mentioned moderate slowing of background activity [48], 'non-specific changes' [17], temporal slow wave dysrhythmia [17] and intermittent frontal high am plitude waves [20,48,59], particularly in the late stages of illness. The difference between normal or nearly normal findings in Pick's disease and progressive abnormalities in AD has been demonstrated using traditional EEG methods [19,20].…”

Section: Discussionmentioning

confidence: 99%

Frontal Lobe Degeneration and Alzheimers Disease: A Controlled Study on Clinical Findings, Volumetric Brain Changes and Quantitative Electroencephalography Data

Förstl

Besthorn²,

Hentschel³

et al. 1996

Dement Geriatr Cogn Disord

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Ten patients with a clinical diagnosis of frontal lobe degeneration (FLD) were compared with a group of patients with probable Alzheimer’s disease (AD) and with nondemented controls matched for gender and age. In comparison with AD, the duration of illness was slightly shorter and cognitive performance was better in patients with FLD. The greatest enlargement of cerebro-spinal fluid volumes was found in FLD and this effect was most pronounced in the anterior fissure and lateral ventricles. Estimates of EEG band-power and EEG coherence in FLD were not remarkably different from nondemented controls, whereas delta- and theta-power were significantly increased in AD. These observations may indicate different disease processes with a dissociation of volumetric computed tomography and quantitative EEG changes, which may be of differential diagnostic value.

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Section: Discussionmentioning

confidence: 99%

Frontal Lobe Degeneration and Alzheimers Disease: A Controlled Study on Clinical Findings, Volumetric Brain Changes and Quantitative Electroencephalography Data

Förstl

Besthorn²,

Hentschel³

et al. 1996

Dement Geriatr Cogn Disord

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“…However, due to the clinical similarities, the differential diagnosis between FLT and Pick's disease is very difficult and sometimes can only be distinguished at autopsy (Meyers et al, 1992;Kumar and Gottlieb, 1993). A family history of dementia is often helpful, strongly suggesting a diagnosis of FLT (Neary et al, 1988 andMann et al, 1993;Hodgson et al, 1993). In spite of the fact that our patient does not have a positive family history of dementia, we consider that based on the data available (clinical, neuroimaging and EEG findings) a definite diagnosis of Pick's disease is not possible.…”

Section: Discussionmentioning

confidence: 99%

Misleading clinical picture due to frontal lobe dementia

Jtip

Cournoyer

Caramelli

et al. 1995

Int J Geriat Psychiatry

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“…3 Die differentialdiagnostische Bedeutung psychiatrischer und neurologischer Befunde sowie apparativer Zusatzuntersuchungen bei der Unterscheidung von Frontallappendegeneration und Demenz vom Alzheimer-Typ.Pick und diefokalen Hirnatrophienund Frauen waren nahezu gleich häufig betroffen. Es ergaben sich Hinweise auf eine häufigere genetische, möglicherweise autosomal dominante Erkrankung(41,48,62,90,97). Etwa die Hälfte der beobachteten Fälle wurde als familiär angesehen(92).…”

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Pick und die fokalen Hirnatrophien

Förstl

Baldwin²

1994

Fortschr Neurol Psychiatr

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In 1892 Arnold Pick presented the case of an elderly demented patient with severe aphasia and global brain atrophy most accentuated at the left temporal lobe. Picks main interest was the relationship between focally accentuated brain degeneration and focally accentuated neuropsychological deficits, and this was what he wanted to demonstrate. He made no effort to describe a new form of dementia. The term "Pick's disease" which was introduced 30 years later implies the existence of a nosological entity with characteristic clinical features, localisation and histology. The neuropathological causes of focally accentuated brain atrophies are varied. Neocortical pyramidal cell loss with or without spongiform changes, cortical and subcortical gliosis have commonly been described. Achromatic neuronal ballooning ("Pick's cells") and intraneuronal argentophilic inclusion bodies ("Pick's bodies"), Alzheimer type plaques and tangles and other features were found in a smaller number of cases. Several authors confirmed an association between the localisation of brain atrophy and its clinical manifestations, but no convincing relationship has been demonstrated between the clinical symptoms and the underlying histology. In several studies frontal lobe degeneration was found in 10% to 20% of the demented patients, whereas aphasia, apraxia and other pronounced deficits in the context of focally accentuated brain atrophy were described less frequently. An early clinical distinction between atypical early stages of Alzheimer's disease and other forms of slowly progressive dementing disorders is virtually impossible in these cases. Prospective studies documenting the clinical and anatomical findings are needed to examine the reliability of these surmised brain-behaviour relationships in degenerative brain diseases more reliably. A descriptive approach offers a better basis for data collection than the premature diagnosis of a poorly defined disease like "Pick's".

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Dementia of frontal lobe type in monozygotic twins

Abstract: A pair of monozygotic twins who are concordant for dementia of frontal lobe type are discussed. This is believed to be the first case report of twins with this type of dementia. The salient features of dementia of frontal lobe type are also discussed.

Cited by 3 publications

References 12 publications

Frontal Lobe Degeneration and Alzheimers Disease: A Controlled Study on Clinical Findings, Volumetric Brain Changes and Quantitative Electroencephalography Data

Frontal Lobe Degeneration and Alzheimers Disease: A Controlled Study on Clinical Findings, Volumetric Brain Changes and Quantitative Electroencephalography Data

Misleading clinical picture due to frontal lobe dementia

Pick und die fokalen Hirnatrophien

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