Dementia paralytica (neurosyphilis): A clinical case study

Ilanković, Nikola; Ivković, Maja; Sokić, Dragoslav; Ilanković, Andrej; Milovanović, Srdjan; Filipović, Branislav; Tiosavljević, Danijela; Ilanković, Vera; Bojić, Veronika

doi:10.1080/15622970310029908

Cited by 8 publications

(6 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For instance, Fujimoto et al [6] reported a case who presented with immediate, recent and remote memory disturbances. This was consistent with previously reported cases [7,8,9,10,11]. Unfortunately, these studies lacked systematic neuropsychological examinations, and they did not include other dementia patient groups (e.g.…”

Section: Introductionsupporting

confidence: 91%

Cognitive Impairment in Mild General Paresis of the Insane: AD-Like Pattern

Wang¹,

Guo²,

Zhou

et al. 2011

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

Background/Aims: We investigated the clinical and cognitive features of patients with mild general paresis of the insane (GPI) in comparison to Alzheimer’s disease (AD) patients, mild frontotemporal dementia (FTD) patients and normal elderly individuals. Methods: Twelve patients with mild GPI, 24 patients with mild AD, 11 patients with mild FTD and 36 healthy subjects participated in the current study. A comprehensive neuropsychological battery was used to assess memory, language, attention, executive function, visuospatial ability, etc. In addition, cranial MRI were also obtained from the 3 patient groups. Results: Mild GPI showed a similar pattern of cognitive impairments in memory, language and executive function to mild AD, but a mixed pattern of dissimilarities to mild FTD. Mild GPI patients had more complaints and positive signs in the nervous system than mild AD patients, and cranial MRI results showed that mild GPI patients usually had atrophy of the medial temporal lobe. Conclusion: There is an overall decline in cognitive functions of mild GPI patients, which is comparable to that in AD patients, suggesting that there is a wide range of structural changes in the brains of mild GPI patients as well. However, further studies are needed to verify whether these structural changes are similar to those in AD.

show abstract

Section: Introductionsupporting

confidence: 91%

Cognitive Impairment in Mild General Paresis of the Insane: AD-Like Pattern

Wang¹,

Guo²,

Zhou

et al. 2011

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

show abstract

“…Reference was made to dementia more than 1700 years ago during the time of the Roman empire [240]. Throughout history, various types of dementia have been associated with (1) infections, e.g., neurosyphilis [241], kuru [242], Creutzfeldt-Jakob disease [243], and HIV-AIDS [244]; (2) genetic mutations, e.g., Huntington's disease [245], DS [246]; (3) vascular deterioration in the form of multi-infarct dementia [247]; (4) traumatic head injury, e.g., post-traumatic dementia [248] and dementia pugilistica [249]; and (5) environmental or lifestyle factors, e.g., dialysis dementia [35], Balint's syndrome (an occupational dementia) [36], ALS/PD [250], and Wernicke-Korsakoff Syndrome or alcohol-related dementia [251]. In 1979, AD accounted for closer to 50% of all dementia cases [252].…”

Section: Historical Perspective Of Ad and Other Dementiasmentioning

confidence: 99%

Chronic Aluminum Intake Causes Alzheimer's Disease: Applying Sir Austin Bradford Hill's Causality Criteria

Walton

2014

JAD

110

View full text Add to dashboard Cite

Industrialized societies produce many convenience foods with aluminum additives that enhance various food properties and use alum (aluminum sulfate or aluminum potassium sulfate) in water treatment to enable delivery of large volumes of drinking water to millions of urban consumers. The present causality analysis evaluates the extent to which the routine, life-long intake, and metabolism of aluminum compounds can account for Alzheimer's disease (AD), using Austin Bradford Hill's nine epidemiological and experimental causality criteria, including strength of the relationship, consistency, specificity, temporality, dose-dependent response, biological rationale, coherence with existing knowledge, experimental evidence, and analogy. Mechanisms that underlie the risk of low concentrations of aluminum relate to (1) aluminum's absorption rates, allowing the impression that aluminum is safe to ingest and as an additive in food and drinking water treatment, (2) aluminum's slow progressive uptake into the brain over a long prodromal phase, and (3) aluminum's similarity to iron, in terms of ionic size, allows aluminum to use iron-evolved mechanisms to enter the highly-active, iron-dependent cells responsible for memory processing. Aluminum particularly accumulates in these iron-dependent cells to toxic levels, dysregulating iron homeostasis and causing microtubule depletion, eventually producing changes that result in disconnection of neuronal afferents and efferents, loss of function and regional atrophy consistent with MRI findings in AD brains. AD is a human form of chronic aluminum neurotoxicity. The causality analysis demonstrates that chronic aluminum intake causes AD.

show abstract

“…B. Primäraffekte oder Syphilide werden von kognitiv beeinträchtigten Patienten nicht wahrgenommen oder schizophrene Patienten suchen trotz syphilitischer Effloreszenzen keinen Arzt auf) [40]. Schließlich sollte bei allen Patien− ten mit neu aufgetretenen psychotischen oder demenziellen Zustandsbildern der Liquor unter− sucht werden, um eine Neurosyphilis differenzi− aldiagnostisch ausschließen respektive frühzei− tig behandeln zu können [34]. Auch wenn eine Restitutio ad integrum bei bereits eingetretenem Hirnparenchymverlust nicht mehr möglich ist, so ist zumindest die Defektheilung bzw.…”

Section: Symptomatische Therapie Mit Psychopharmakaunclassified

“…Nach Rolfs u. Mitarb. [39] liegt eine Therapiebedürftigkeit vor bei positivem 19S−IgM−FTA−ABS und/oder bei VDRL mit einer Titerstufe von mindestens 1 : 8 oder einer Titerer− Neben einer eingehenden psychiatrischen und neurologischen Befunderhebung sind serologische und Liquoruntersuchungen zur Diagnostik der Neurosyphilis unerlässlich.mehr Jahren, eine Liquorpunktion zum Aus− schluss einer Neurosyphilis indiziert[34]. Prinzi− piell gilt, dass bei allen Syphilis−HIV−koinfizier− ten Patienten eine Liquoruntersuchung durchge− führt werden soll, da bis zu 40 % dieser Patienten bereits im Sekundärstadium der Syphilis einen pathologischen Liquorbefund aufweisen[16].Die progressive Paralyse führt unbehandelt zu vegetativem Verfall mit letalem Ende.…”

unclassified

Neurosyphilis - Diagnose und Therapie vor psychiatrischem Hintergrund

Rothenhäusler¹

2007

Fortschr Neurol Psychiatr

View full text Add to dashboard Cite

Dementia paralytica (neurosyphilis): A clinical case study

Cited by 8 publications

References 1 publication

Cognitive Impairment in Mild General Paresis of the Insane: AD-Like Pattern

Cognitive Impairment in Mild General Paresis of the Insane: AD-Like Pattern

Chronic Aluminum Intake Causes Alzheimer's Disease: Applying Sir Austin Bradford Hill's Causality Criteria

Neurosyphilis - Diagnose und Therapie vor psychiatrischem Hintergrund

Contact Info

Product

Resources

About