Dementia, stroke and migraine — Some common pathological mechanisms

Sas, Katalin; Párdutz, Árpád; Toldi, József; Vécsei, László

doi:10.1016/j.jns.2010.08.001

Cited by 26 publications

(17 citation statements)

References 169 publications

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“…Migraine existed in some specific syndromes e.g., cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, hereditary endotheliopathy with retinopathy, nephropathy and stroke, stroke-like episodes and cerebroretinal vasculopathy etc, in which they may have obvious brain microangiopathy. In addition, patent foramen ovale is commonly observed among migraineurs than controls 104. Overall, these structural changes are not the pathognomic characteristics of migraine since other diseases for example stroke may associate these signs.…”

Section: Image Studies and Pathologymentioning

confidence: 91%

“…It is of interest what these brain white matter lesions mean pathologically. Currently, these lesions have been suggested as infarct in origin resulted from hypoperfusion or embolism rather than arteriosclerosis or small vessel disorder, while its exact etiology is really unknown since postmortem report is still unavailable 104. Migraine existed in some specific syndromes e.g., cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, hereditary endotheliopathy with retinopathy, nephropathy and stroke, stroke-like episodes and cerebroretinal vasculopathy etc, in which they may have obvious brain microangiopathy.…”

Section: Image Studies and Pathologymentioning

confidence: 99%

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Irritable Bowel Syndrome and Migraine: Bystanders or Partners?

Chang¹,

Lu²

2013

J Neurogastroenterol Motil

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Irritable bowel syndrome (IBS) and migraine are distinct clinical disorders. Apart from the characteristics of chronic and recurrent pain in nature, these pain-related disorders apparently share many similarities. For example, IBS is female predominant with community prevalence about 5-10%, whereas that of migraine is 1-3% also showing female predominance. They are often associated with many somatic and psychiatric comorbidities in terms of fibromyaglia, chronic fatigue syndrome, interstitial cystitis, insomnia and depression etc., even the IBS subjects may have coexisted migraine with an estimated odds ratio of 2.66. They similarly reduce the quality of life of victims leading to the social, medical and economic burdens. Their pathogeneses have been somewhat addressed in relation to biopsychosocial dysfunction, heredity, genetic polymorphism, central/visceral hypersensitivity, somatic/cutaneous allodynia, neurolimbic pain network, gonadal hormones and abuses etc. Both disorders are diagnosed according to the symptomatically based criteria. Multidisciplinary managements such as receptor target new drugs, melantonin, antispasmodics, and psychological drugs and measures, complementary and alternatives etc. are recommended to treat them although the used agents may not be necessarily the same. Finally, the prognosis of IBS is pretty good, whereas that of migraine is less fair since suicide attempt and stroke are at risk. In conclusion, both distinct chronic pain disorders to share many similarities among various aspects probably suggest that they may locate within the same spectrum of a pain-centered disorder such as central sensitization syndromes. The true pathogenesis to involve these disorders remains to be clarified in the future.

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Section: Image Studies and Pathologymentioning

confidence: 91%

Section: Image Studies and Pathologymentioning

confidence: 99%

Irritable Bowel Syndrome and Migraine: Bystanders or Partners?

Chang¹,

Lu²

2013

J Neurogastroenterol Motil

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“…This is illustrated by the plethora of recent reviews associating mitochondrial dysfunction with specific diseases, e.g. [1][2][3][4][5][6][7][8][9][10][11][12][13]. In parallel, there is an increasing realization in the pharmaceutical industry that candidate drugs must be tested at an early stage for adverse effects on mitochondria [14].…”

Section: Introductionmentioning

confidence: 99%

Assessing mitochondrial dysfunction in cells

Brand¹,

Nicholls²

2011

Biochemical Journal

213

301

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Assessing mitochondrial dysfunction requires definition of the dysfunction to be investigated. Usually, it is the ability of the mitochondria to make ATP appropriately in response to energy demands. Where other functions are of interest, tailored solutions are required. Dysfunction can be assessed in isolated mitochondria, in cells or in vivo, with different balances between precise experimental control and physiological relevance. There are many methods to measure mitochondrial function and dysfunction in these systems. Generally, measurements of fluxes give more information about the ability to make ATP than do measurements of intermediates and potentials. For isolated mitochondria, the best assay is mitochondrial respiratory control: the increase in respiration rate in response to ADP. For intact cells, the best assay is the equivalent measurement of cell respiratory control, which reports the rate of ATP production, the proton leak rate, the coupling efficiency, the maximum respiratory rate, the respiratory control ratio and the spare respiratory capacity. Measurements of membrane potential provide useful additional information. Measurement of both respiration and potential during appropriate titrations enables the identification of the primary sites of effectors and the distribution of control, allowing deeper quantitative analyses. Many other measurements in current use can be more problematic, as discussed in the present review.

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“…epilepsy, stroke, patent foramen ovale, high antiphospholipid titers, depression, arterial dissection, fibromyalgia and dementia. [31][32][33][34][35][36][37][38][39] The pathogenesis of migraine with aura is generally accepted to be caused by cortical spreading depression (CSD) of electrical activity characterized by transient neuronal depolarization and hyperperfusion, and subsequent hyperpolarization, hypoperfusion and neuronal dysfunction. This spreads at a rate of 3-5 mm per minute across the cortex and in animal models and humans has been seen to involve the hippocampus, at times leading to hypoxia in the CA1 field.…”

Section: Migrainementioning

confidence: 99%

Transient global amnesia

Boovalingam

Shah

2013

Rev. Clin. Gerontol.

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SummaryTransient global amnesia (TGA) has been described since the 19th century. It is characterized by an episode of anterograde and retrograde amnesia lasting less than 24 hours. During this episode patients are conscious and able to interact normally, but are typically distressed and repeat questions without remembering explanations. Despite progress in medical imaging, no cause for the condition has been proven. Prognosis is excellent and management centres on recognition and reassurance. We describe the epidemiology, pathophysiology, clinical features and management.

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Dementia, stroke and migraine — Some common pathological mechanisms

Cited by 26 publications

References 169 publications

Irritable Bowel Syndrome and Migraine: Bystanders or Partners?

Irritable Bowel Syndrome and Migraine: Bystanders or Partners?

Assessing mitochondrial dysfunction in cells

Transient global amnesia

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