Dementia with Lewy Bodies (DLB) presenting with catatonic symptoms

Lakshmana, Raju; Sundram, Suresh; Cairns, Fiona

doi:10.1111/j.1479-8301.2006.00108.x

Cited by 9 publications

(8 citation statements)

References 14 publications

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“…Although catatonia is known to occur at any age, 3 the present case was unique in terms of the late age of presentation with Alzheimer's dementia and diabetes leading, which led to a diagnostic dilemma and problems with management. Catatonia occurring during the course of dementia has been reported with Lewy body dementia or in association with the use of donepezil in patients with Parkinson's disease 4 . A Medline‐based search using the key words ‘catatonia’ and ‘Alzheimer’ did not return any reports of cases similar to the present one.…”

Section: Discussionmentioning

confidence: 63%

Catatonia in an Alzheimer's dementia patient

Kendurkar

2008

Psychogeriatrics

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The present case report is of an 82-year-old woman, a known case of Alzheimer's dementia, referred to the Department of Psychiatry for evaluation regarding the sudden onset of a change in behavior. A diagnosis of catatonia caused by an acute psychotic illness was made. The patient was given a trial of lorazepam, failing which quetiapine was given, leading to complete resolution in 4 weeks. Quetiapine was withdrawn after 3 months and the patient was found to be well in next 6 months of follow up. Catatonia is known to exist in many disorders. In the elderly, it is reported to occur in primarily four types of disorders: organic, psychotic, mood and toxic. However, a few reports also suggest an association between catatonia and Lewy body dementia. There have been no previous reports of catatonia with Alzheimer's dementia. The planning of management is often difficult in such cases, because no single approach has been found to be absolutely effective.

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Section: Discussionmentioning

confidence: 63%

Catatonia in an Alzheimer's dementia patient

Kendurkar

2008

Psychogeriatrics

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“…In contrast, in 98 patients over 65 years of age admitted to the psychiatric ward of a general hospital, Takács et al ( 17 ) found a prevalence of catatonia in 17% of the cases, most of which were due to a general medical condition. Because catatonic symptoms are commonly found in certain types of primary neurodegenerative dementias [e.g., Lakshmana et al ( 18 ); Ishmora et al ( 19 )], it is surprising that dementia was not particularly associated with catatonia in either study. The reasons for this are unclear, but physicians' lack of familiarity with the manifestations of catatonia may be a sufficient explanation in most cases.…”

Section: Introductionmentioning

confidence: 78%

Case Report: Catatonic Stupor in Behavioral Variant Frontotemporal Dementia

et al. 2022

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Catatonia is a psychomotor syndrome common to several medical and neuropsychiatric disorders. Here, we report on the case of a 95-year-old woman who underwent a radical change in personality characterized by sexual disinhibition, and physical and verbal aggressiveness. Over several months, she developed verbal stereotypies, gait deterioration, and double incontinence. She eventually developed mutism and an active opposition to all attempts to be fed or cared for. Benzodiazepines, olanzapine and electroconvulsive therapy were of no benefit. Magnetic resonance imaging revealed asymmetric (more severe on the right) frontotemporal, parietal, and upper brainstem atrophy. She died from sepsis without recovering from stupor seven years after the onset of symptoms. We believe that the initial behavioral disinhibition was related to the frontotemporal injury, whereas catatonic stupor reflected the progression of the degenerative process to the parietal cortices. Our case adds to the small number of cases of catatonia as a symptom of degenerative dementia. It also supports the idea that damage to the parietal cortex gives rise to pathological avoidance of which catatonic stupor represents an extreme form.

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“…Neurological disorders: Dementia: Catatonia has been described in all dementia types, with reports in patients with Alzheimer’s disease (AD)[ 41 - 43 ]; frontotemporal dementia (FTD)[ 44 - 49 ]; dementia with Lewy bodies (DLB)[ 50 - 55 ]; and other cases with mixed, vascular, or nonspecified dementia[ 56 , 57 ]. Two prospective studies in psychogeriatric units reported a high prevalence of catatonia in patients with dementia using DSM-5 criteria, at 35.3%[ 16 ] and 42.8%[ 11 ].…”

Section: Resultsmentioning

confidence: 99%

Catatonia in older adults: A systematic review

Jaimes-Albornoz¹,

Pellon-Santamaria²,

Nizama-Vía³

et al. 2022

WJP

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BACKGROUND Catatonia is a complex psychomotor syndrome that often goes unrecognized and untreated, even though its classification has evolved in recent years. Prompt and correct identification of catatonia allows for highly effective treatment and prevention of possible complications. The underrecognition of catatonia in older patients is also frequent, and research in this population is scarce. AIM To conduct a systematic review of the literature on catatonia in older people to ascertain its clinical characteristics across settings. METHODS Following the PRISMA guidelines, MEDLINE, EMBASE, and PsycINFO databases were searched from inception to December 2021, with a strategy aimed at identifying all articles published on catatonia in older adults. Titles and abstracts were scanned and selected independently by two authors. Papers investigating issues related to catatonia and/or catatonic symptoms in older people, with English abstracts available, were included. References of selected articles were revised to identify other relevant studies. RESULTS In total, 1355 articles were retrieved. After removing duplicates, 879 remained. Of the 879 identified abstracts, 669 were excluded because they did not meet the inclusion criteria. A total of 210 articles underwent full text review, and 51 were eliminated for various reasons. Fourteen more articles were selected from the references. Overall, 173 articles were reviewed: 108 case reports, 35 case series, 11 prospective cohort studies, 6 case-control studies, 3 retrospective cohort studies and 10 reviews. We found several particular aspects of catatonia in this population. Catatonia in older patients is highly prevalent and tends to have a multifactorial etiology. Older patients, compared to younger patients, have a higher risk of developing catatonia with benzodiazepine (BZD) withdrawal, in bipolar disorder, and in the general hospital. Age, together with other risk factors, was significantly associated with the incidence of deep venous thrombosis, neuroleptic malignant syndrome poor outcome, other complications and mortality. Treatment with BZDs and electroconvulsive therapy is safe and effective. Prompt treatment of its cause is essential to ensure a good prognosis. CONCLUSION Catatonia in older patients is highly prevalent and tends to have a multifactorial etiology. The risk of developing catatonia in some settings and conditions, as well as of developing complications, is high in this population. Symptomatic treatment is safe and effective, and timely etiologic treatment is fundamental.

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Dementia with Lewy Bodies (DLB) presenting with catatonic symptoms

Cited by 9 publications

References 14 publications

Catatonia in an Alzheimer's dementia patient

Catatonia in an Alzheimer's dementia patient

Case Report: Catatonic Stupor in Behavioral Variant Frontotemporal Dementia

Catatonia in older adults: A systematic review

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