Dementia with lewy bodies: Severe impairment of real-space navigation skills examined with human analogue of morris water maze and their structural underpinnings

Nedelská, Zuzana; Laczó, Jan; Uller, Miroslav; Vyhnálek, Martin; Fripp, Jürgen; Vlček, Kamil; Pařízková, Martina; Hort, Jakub

doi:10.1016/j.jns.2017.08.283

Cited by 8 publications

(7 citation statements)

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“…As stated in the introduction, there is emerging evidence from other studies that also persons with DLB and VaD have impaired spatial navigation abilities. [7][8][9][10] Our results further concur with the findings from the Einstein Aging Study, where the association between FMT and incident MCI was driven by nonamnestic MCI and not by amnestic MCI (aMCI). 12 Their finding was supported by subanalyses in which FMT predicted decline in executive function, but not progression of memory impairment.…”

Section: Discussionsupporting

confidence: 87%

“…2,5 Impairments in spatial navigation are traditionally closely linked to the integrity of structures in the medial temporal lobe, which is the area where the first cell loss occurs in the development of Alzheimer disease (AD). 6 However, spatial impairments are also observed in patients with other dementia subtypes such as dementia with Lewy bodies (DLB) 7,8 and vascular dementia (VaD). 9,10 Impairments in spatial navigation might offer a possibility for early identification of persons likely to subsequently develop dementia.…”

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confidence: 99%

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Spatial Navigation and Its Association With Biomarkers and Future Dementia in Memory Clinic Patients Without Dementia

et al. 2022

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Background and Objectives:Impaired spatial navigation is considered an early sign in many neurodegenerative diseases. We aimed to determine if spatial navigation was associated with future dementia in patients with subjective cognitive decline (SCD) or mild cognitive impairment (MCI), and to explore associations between spatial navigation and biomarkers of Alzheimer’s disease (AD) and neurodegeneration.Methods:The study included memory clinic patients without dementia in the longitudinal BioFINDER cohort. The Floor Maze Test (FMT) was used to assess spatial navigation at baseline. Conversion to dementia were evaluated at 2- and 4-year follow-ups. At baseline, amyloid-β 42/40 ratio, phosphorylated-tau (p-tau) and neurofilament light (NfL) were analysed in CSF. Cortical thickness and volume of regions relevant for navigation, and white matter lesion volume were quantified from MRI. The predictive role of the FMT for conversion to all-cause dementia was analysed using logistic regression analyses in two models; 1) controlled for age, sex and education, and 2) adding baseline cognitive status and MMSE. Associations between FMT and biomarkers were adjusted for age, sex, and cognitive status (SCD or MCI).Results:156 patients with SCD and 176 patients with MCI were included. FMT total time was associated with progression to all-cause dementia in model 2 at 2-year (OR 1.10, 95% CI 1.04, 1.16) and at 4-year follow-up (OR 1.10, 95% CI 1.04, 1.16), i.e., a 10 % increase in odds of developing dementia per every 10 sec increase in FMT. In the adjusted analyses, P-tau and NfL was associated with FMT total time, as well as hippocampal volume, parahippocampal and inferior parietal cortical thickness. Amyloid-β 42/40 ratio was not associated with FMT total time.Discussion:Impaired spatial navigation was associated with conversion to dementia within 2 and 4 years, and with key CSF and MRI biomarkers for AD and neurodegeneration in patients with SCD and MCI. This supports its use in early cognitive assessments, but the predictive accuracy should be validated in other cohorts.Classification of Evidence:This is a Class 1 prospective cohort study demonstrating association of baseline markers of spatial recognition with development of dementia in patients with SCD or MCI at baseline.

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Section: Discussionsupporting

confidence: 87%

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confidence: 99%

Spatial Navigation and Its Association With Biomarkers and Future Dementia in Memory Clinic Patients Without Dementia

et al. 2022

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“…For instance, AD and its prodromal stages affect the allocentric frames of reference (Serino, Cipresso, Morganti, & Riva, 2014;Tuena et al, 2021). Conversely, PD, dementia with Lewy bodies, and vascular dementia impact egocentric processing (Humphries et al, 2016;Lowry, Puthusseryppady, Coughlan, Jeffs, & Hornberger, 2020;Nedelska et al, 2017;Thurm et al, 2016). In addition, as some neurodegenerative diseases, such as frontotemporal dementias, parkinsonisms, and AD, lead to differences in naming of manipulable and non-manipulable objects (e.g., Cotelli et al, 2006), it could be interesting to investigate linguistic affordances in these populations.…”

Section: Context Effects and Individual Differences In Spatial Aspect...mentioning

confidence: 99%

Ecological meanings: A consensus paper on individual differences and contextual influences in embodied language

Ibáñez¹,

Kühne²,

Miklashevsky³

et al. 2022

Preprint

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Embodied theories of cognition consider many aspects of language and other cognitive domains as the result of sensory and motor processes. In this view, the appraisal and the use of concepts are based on mechanisms of simulation grounded on prior sensorimotor experiences. Even though these theories continue receiving attention and support, increasing evidence indicates the need to consider the flexible nature of the simulation process, and to accordingly refine embodied accounts. In this consensus paper, we discuss two potential sources of variability in experimental studies on embodiment of language: individual differences and context. Specifically, we show how factors contributing to individual differences may explain inconsistent findings in embodied language phenomena. These factors include sensorimotor or cultural experiences, imagery, context-related factors, and cognitive strategies. We also analyze the different contextual modulations, from single words to sentences and narratives, as well as the top-down and bottom-up influences. Similarly, we review recent efforts to include cultural and language diversity, aging, neurodegenerative diseases, and brain disorders, as well as bilingual evidence into the embodiment framework. We address the importance of considering individual differences and context in clinical studies to drive translational research more efficiently, and we indicate recommendations on how to correctly address these issues in future research. Systematically investigating individual differences and context may contribute to understanding the dynamic nature of simulation in language processes, refining embodied theories of cognition, and ultimately filling the gap between cognition in artificial experimental settings and cognition in the wild (i.e., in everyday life).

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“…These observations are corroborated by neuropathological evidence indicating that the highest rate of atrophy has been found in areas of the hippocampus and retrosplenial cortex which are known to be implicated in spatial representations ( Vlċek and Laczó, 2014 ). However, recent research has revealed that problems with navigation and spatial memory can also be observed in other types of neurodegenerative diseases associated with cognitive decline including dementia with Lewy bodies, frontotemporal dementia, Parkinson’s disease, and vascular cognitive impairment ( Uc et al, 2007 ; Nedelska et al, 2017 ; Tu et al, 2017 ; Lowry et al, 2020 ). Notably, subjective complaints about navigation difficulties and deficits have been reported in individuals with MCI regardless of whether it is of the amnestic or non-amnestic subtype ( Cerman et al, 2018 ; Tuena et al, 2021a ).…”

Section: Introductionmentioning

confidence: 99%

Enhancing spatial navigation skills in mild cognitive impairment patients: a usability study of a new version of ANTaging software

Stramba-Badiale,

Tuena,

Goulene

et al. 2024

Front. Hum. Neurosci.

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IntroductionMild Cognitive Impairment (MCI) often presents challenges related to spatial navigation and retention of spatial information. Navigating space involves intricate integration of bodily and environmental cues. Spatial memory is dependent on two distinct frame of reference systems for organizing this information: egocentric and allocentric frames of reference. Virtual Reality (VR) has emerged as a promising technology for enhancing spatial navigation skills and spatial memory by facilitating the manipulation of bodily, environmental, and cognitive cues.MethodsThis usability study was based on a fully within-subjects design in which seven MCI patients underwent two kinds of VR conditions: participants were required to complete the ANTaging demo both in Oculus Rift S (immersive condition) and in Samsung UHD 4K monitor (semi-immersive condition). Participants were seated and they had to use a foot-motion pad to navigate and explore the environment to collect and relocate some objects in the virtual environment. Post-interaction, users provided feedback on their experiences. Additionally, usability, potential side effects, data analysis feasibility, and user preferences with immersive and semi-immersive technologies were assessed through questionnaires.ResultsResults indicated higher usability ratings for the semi-immersive setup, with fewer negative effects reported compared to the immersive counterpart. According to qualitative analyses of the interviews, patients do seem to like both VR apparatuses even though the semi-immersive condition was perceived as the most suitable choice because of the size of the screen. Patients generally found it difficult to remember object locations. Participants expressed the need for more practice with the foot-motion pad, despite an overall positive experience. They generally would like to use this system to improve their memory.DiscussionIdentifying these key aspects was crucial for refining the system before the upcoming clinical trial. This study sheds light on the potential of semi-immersive VR in aiding individuals with MCI, paving the way for enhanced spatial navigation interventions.

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Dementia with lewy bodies: Severe impairment of real-space navigation skills examined with human analogue of morris water maze and their structural underpinnings

Cited by 8 publications

References 0 publications

Spatial Navigation and Its Association With Biomarkers and Future Dementia in Memory Clinic Patients Without Dementia

Spatial Navigation and Its Association With Biomarkers and Future Dementia in Memory Clinic Patients Without Dementia

Ecological meanings: A consensus paper on individual differences and contextual influences in embodied language

Enhancing spatial navigation skills in mild cognitive impairment patients: a usability study of a new version of ANTaging software

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