Demethylchlortetracycline and Tetracycline Compared

The Relationship of Results of Sputum Cultures to Clinical Effect in a Controlled Trial of Continuous Antibiotic Treatment of Chronic Bronchitis with Demethylchlortetracycline or Penicillin‐V

“…It can be deduced from these data that the peak blood levels of DMCT in the patients using this drug in this study were high enough to suppress both H.-influenzae and pneumococci. In this regard it seems worth mentioning that Knothe (9) and Sweeney et al (21) showed that the serum levels of DMCT six hours after a dose of I50 mg or 300 mg may be even higher. These were not tested in this study.…”