Demineralized dentin matrix scaffolds for alveolar bone engineering

Um, In-Woong; Kim, Young-Kyun; Mitsugi, Masaharu

doi:10.4103/jips.jips_62_17

Cited by 54 publications

(60 citation statements)

References 51 publications

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“…Autogenous tooth bone is consisted of demineralized dentin matrix (DDM) largely which is demineralized from dentin, a mainly structure of teeth [32]. The DDM which is the internal stuff may arouse less auto-immunity, therefore the less swelling and pain happened.…”

Section: Discussionmentioning

confidence: 99%

Immediate implant placement in anterior teeth with grafting material of autogenous tooth bone vs xenogenic bone

Zhang²,

Lin³

et al. 2019

Preprint

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Background: The aim of the study was to compare the efficacy of the autogenous tooth bone and xenogenic bone grafted in immediate implant placement with bone defect. Methods: Thirty patients whose compromised anterior teeth need immediate implant placement were enrolled. Autogenous tooth bone made from the extracted teeth by chair-side or the xenogenic bone were used to repaired bone defect. Clinical examination, radiographic assessment about the horizontal bone change in the level of 0mm, 3mm and 6mm below the implant neck and the marginal bone loss were made immediately, 6 and 12 months after implant placement. Questionnaire of the feelings about the surgery were made at the time of removing the sutures. Results: All implants achieved the success criteria without any complications at the follow-up period. The percent of the horizontal bone change and the marginal bone loss at 6 and 12 months were almost the same between two groups (P>.05). The horizontal bone loss at the first or the latter 6 months was almost the same (P>.05). But the horizontal bone loss at the 6 mm level was less than the 0 mm and 3 mm levels at 6 and 12 months (P<.05). Meanwhile patients seem more satisfied with the autogenous tooth bone derived from the questionnaire. Conclusion: The bone volume change in the facial part of the implant after immediate placement is almost the same between two groups. Providing clinical evidence that the autogenous tooth bone made from compromised tooth can be an acceptable bone graft material.

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Section: Discussionmentioning

confidence: 99%

Immediate implant placement in anterior teeth with grafting material of autogenous tooth bone vs xenogenic bone

Zhang²,

Lin³

et al. 2019

Preprint

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“…Although numerous bone morphogenetic protein (BMP) carriers have been tested, such as collagen, demineralized bovine bone, and hydroxyapatite, these carriers have several shortcomings, such as rapid resorption, lack of long-term maintenance of volume, and incompetent release of BMP. Processed demineralized dentin is already recognized as a rhBMP-2 carrier, since it facilitates induction of new bone formation and helps to release BMP slowly [44]. A recent animal study by Kim et al demonstrated that DDM dissolves rhBMP-2 more gradually and steadily than other tricalcium phosphates (TCP) and bovine bone, establishing that particulated DDM is the most effective BMP carrier [31].…”

Section: Discussionmentioning

confidence: 99%

“…Dentin and bone have similar compositions, consisting of 18% collagen, 70% hydroxyapatite, and 2% noncollagenous protein [24]. Besides the type I collagens in dentin, microporous dentinal tubules can seize BMP solution and widen the contact area with proteins which can facilitate the continuous binding and release of BMPs [19,44].…”

Section: Discussionmentioning

confidence: 99%

Volumetric, Radiographic, and Histologic Analyses of Demineralized Dentin Matrix Combined with Recombinant Human Bone Morphogenetic Protein-2 for Ridge Preservation: A Prospective Randomized Controlled Trial in Comparison with Xenograft

et al. 2018

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Featured Application: Novel technology of bone regeneration.Abstract: The aim of this study was to evaluate the clinical, volumetric, radiographic, and histologic aspects of autogenous demineralized dentin matrix (DDM) combined with recombinant human bone morphogenetic protein-2 (rhBMP-2) used for ridge preservation, compared to those of deproteinized bovine bone with collagen (DBBC). Following atraumatic extraction, the socket was filled with DBBC, DDM, or rhBMP-2/DDM. Scanned images of dental casts and cone beam computed tomographs (CBCT) were superimposed for the calculation of soft and hard tissue volume alteration. Preoperative and postoperative measurements of the height and width of the alveolar ridge were compared using CBCT images. After 4 months, bone specimens were harvested for histomorphometric assessment. Loss of hard and soft tissue volume occurred at 4 months after extraction and ridge preservation in all groups. No volumetric differences were detected among the three groups before and 4 months after ridge preservation. The reduction in the horizontal width at 5 mm was higher in the DBBC compared to the DDM. Histologically, approximately 40% newly formed bone was founded in rhBMP-2/DDM group. The autogenous dentin matrix used to fill the socket was as beneficial for ridge preservation as conventional xenografts. The combination of rhBMP-2 with dentin matrix also demonstrated appreciable volumetric stability and higher new bone formation compared to DDM alone and DBBC.

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“…DDM is produced by acid extraction of dentin through a process that removes the inorganic mineral component and leaves a type I collagen framework. 24 Demineralization also exposes HD-GFs, including ED-BMPs, and improves the osteoinductivity of DDM. 25 The degree of demineralization achieved when using 24% ethylenediaminetetraacetic acid was not available.…”

Section: Preparation Of Demineralized Dentin Matrix As a Carrier Formentioning

confidence: 99%

Histological Review of Demineralized Dentin Matrix as a Carrier of rhBMP-2

Kim

et al. 2020

Tissue Engineering Part B: Reviews

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In 2007, recombinant human bone morphogenetic protein-2 (rhBMP-2) was approved for use in humans at a concentration of 1.5 mg/mL with absorbable collagen sponges as an alternative to autogenous bone grafts for alveolar ridge augmentation, defects associated with extraction sockets, and sinus augmentation. However, the use of supraphysiological doses and the insufficient retention of rhBMP-2, when delivered through collagen sponge, result in dose-dependent side effects related to off-label use. Demineralized dentin matrix (DDM), an osteoinducing bone substrate, has been used as an rhBMP-2 carrier since 1998. In addition, DDM has both microparticle and nanoparticle structures, which do not undergo remodeling, unlike bone. In vitro, DDM is a suitable carrier for BMP-2, with the continued release over 30 days at concentrations sufficient to stimulate osteogenic differentiation. In this review, we discuss the histological outcomes of DDM loaded with rhBMP-2 to highlight the biological functions of exogenous rhBMP-2 associated with the DDM carrier in clinical applications in implant dentistry.Keywords: bone morphogenetic protein, bone substitute, demineralized dentin matrix Impact StatementDemineralized dentin matrix (DDM) has been used as an recombinant human bone morphogenetic protein (rhBMP-2) carrier and osteo-inducing bone substrate to facilitate continued release and stimulate osteogenic differentiation. In this review, we discuss the histological outcomes of DDM loaded with rhBMP-2 in order to highlight the biological functions of exogenous rhBMP-2 associated with the DDM carrier in clinical applications in implant dentistry.

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Demineralized dentin matrix scaffolds for alveolar bone engineering

Cited by 54 publications

References 51 publications

Immediate implant placement in anterior teeth with grafting material of autogenous tooth bone vs xenogenic bone

Immediate implant placement in anterior teeth with grafting material of autogenous tooth bone vs xenogenic bone

Volumetric, Radiographic, and Histologic Analyses of Demineralized Dentin Matrix Combined with Recombinant Human Bone Morphogenetic Protein-2 for Ridge Preservation: A Prospective Randomized Controlled Trial in Comparison with Xenograft

Histological Review of Demineralized Dentin Matrix as a Carrier of rhBMP-2

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