Demineralized Freeze-Dried Bone and Modified Hydroxyapatite Granules in Patients Requiring Immediate Dental Implants

Pragna, K; Bulkar, Vikas; Reddy, R Naveen; Sayed, Arshad Jamal; Hussain, Mohammed Abid; Khader, Anas Abdul

doi:10.4103/jpbs.jpbs_116_22

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Another study compared the effects of DFDBA and modified HA granules in patients requiring immediate dental implants. A nonsignificant difference was observed 142 . A fully synthetic BCP consisting of 60% HA with 40% β‐TCP was used to elevate the floor of the upper frontal sinus.…”

Section: Applicationsmentioning

confidence: 98%

See 1 more Smart Citation

Multiple biomaterials for immediate implant placement tissue repair: Current status and future perspectives

Su,

Jia,

Wang

et al. 2024

MedComm – Biomaterials and Applications

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Immediate oral implant placement is a widely accepted technique, known for its efficacy in reducing treatment duration, surgical visits, and overall healing time. One of the primary challenges associated with immediate implant placement is the attainment of initial stability. The inevitable loss of bone and soft tissue after extraction poses a risk to implant osseointegration in both vertical and horizontal dimensions. Guided tissue regeneration/guided bone regeneration (GTR/GBR) is a well‐established method for periodontal regeneration. However, current GTR/GBR membranes lack tissue inherent regeneration properties and necessitate combination with grafts to enhance tissue recovery. In this context, biomaterials have emerged as a promising option due to their good biocompatibility, biodegradability, and bioactive properties. They present a potential alternative to standard autologous/allograft procedures. The field of biomaterials for bone regeneration has rapidly evolved, developing new guiding materials and engineering techniques. These advances have become integral in addressing tissue defects at the immediate implant site. Various materials such as bioceramics, natural polymers, and synthetic polymers have been used for tissue repair. This article undertakes an etiological examination of tissue deficiency associated with immediate implant placement. Additionally, it reviews the advantages and disadvantages of a variety of biomaterials, aiming to provide references for clinical treatment and areas for further investigation.

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Section: Applicationsmentioning

confidence: 98%

“…A nonsignificant difference was observed. 142 A fully synthetic BCP consisting of 60% HA with 40% β-TCP was used to elevate the floor of the upper frontal sinus. After 6 months of healing, histology and imaging demonstrated mature bone tissue formation and adequate bone volume in the maxillary sinus.…”

Section: Bone Tissuementioning

confidence: 99%

Multiple biomaterials for immediate implant placement tissue repair: Current status and future perspectives

Su,

Jia,

Wang

et al. 2024

MedComm – Biomaterials and Applications

View full text Add to dashboard Cite

show abstract

In vivo trial of bioresorbable mesh cages contained bone graft granules in rabbit femoral bone defects

Yanagisawa,

Hayashi,

Tsuchiya

et al. 2024

Sci Rep

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Bone graft granules implanted in bone defects come into physical contact with the host bone and form interconnected porous structure. However, there exists an accidental displacement of granules to unintended locations and leakage of granules from bone defects. Although covering the defect with a barrier membrane prevents granule emanation, this procedure is troublesome. To resolve these problems, we fabricated bioresorbable mesh cages (BRMc) in this study. Bone graft granules composed of carbonate apatite alone (Gr) and bioresorbable mesh cages (BRMc/Gr) introduced the bone graft granules and were implanted into the bone defect in the rabbit femur. Micro-computed tomography and histological analysis were conducted at 4 and 12 weeks after implantation. Osteoprogenitors in the bloodstream from the host bone passed through the pores of BRMc, penetrated the porous structure of graft granules, and might interact with individual granules. Then bone remodeling could progress actively and new bone was formed. The new bone formation was similar to the host bone at 12 weeks and there were minimal signs of local tissue inflammation. BRMc/Gr could reduce the risk of unwanted new bone formation occurring due to loss of granules from the bone defects compared with Gr because BRMc enclosed granules and prevent granules leakage from bone defects and BRMc could not induce unfavorable effects to forme new bone. Additionally, BRMc/Gr could keep granules assembled in one place, avoid displacement of granules to unintended locations, and carry easily. These results demonstrated that BRMc/Gr was effective in bone regeneration and improved clinical handling.

show abstract

Effects of bioresorbable mesh cages contained bone graft granules in rabbit femoral bone defects.

Yanagisawa,

Hayashi,

Tsuchiya

et al. 2024

Preprint

View full text Add to dashboard Cite

Bone graft granules implanted in bone defects come into physical contact with the host bone and form interconnected porous structure. However, there exists an accidental displacement of granules to unintended locations and leakage of granules from bone defects. Although covering the defect with a barrier membrane prevents granule emanation, this procedure is troublesome. To resolve these problems, we fabricated bioresorbable mesh cages (BMCs) in this study. Bone graft granules composed of carbonate apatite alone (Gr) and bioresorbable mesh cages (BMCs/Gr) introduced the bone graft granules and were implanted into the bone defect in the rabbit femur. Micro-computed tomography and histological analysis were conducted at 4 and 12 weeks after implantation. Osteoprogenitors in the bloodstream from the host bone passed through the pores of BMCs, penetrated the porous structure of graft granules, and might interact with individual granules. Then bone remodeling could progress actively and new bone was formed. The new bone formation was similar to the host bone at 12 weeks and there were minimal signs of local tissue inflammation. BMCs/Gr could reduce the risk of unwanted new bone formation occurring due to loss of granules from the bone defects compared with Gr because BMCs enclosed granules and prevent granules leakage from bone defects and BMCs could not induce unfavorable effects to forme new bone. Additionally, BMCs/Gr could keep specific amounts of granules assembled in one place, avoid displacement of granules to unintended locations, and carry easily. These results demonstrated that BMCs/Gr was effective in bone regeneration and improved clinical handling.

show abstract

Demineralized Freeze-Dried Bone and Modified Hydroxyapatite Granules in Patients Requiring Immediate Dental Implants

Cited by 3 publications

References 6 publications

Multiple biomaterials for immediate implant placement tissue repair: Current status and future perspectives

Multiple biomaterials for immediate implant placement tissue repair: Current status and future perspectives

In vivo trial of bioresorbable mesh cages contained bone graft granules in rabbit femoral bone defects

Effects of bioresorbable mesh cages contained bone graft granules in rabbit femoral bone defects.

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