Demodex-associated dermatologic conditions – A coincidence or an etiological correlate. Review with a report of a rare case of sebaceous adenoma

Dhingra, Kajal Kiran; Saroha, Vijay; Gupta, Parul; Khurana, Nita

doi:10.1016/j.prp.2008.11.013

Cited by 21 publications

(21 citation statements)

References 14 publications

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“…along with the presence of Demodex, immunohistological tests show proliferations of accessory T lymphocytes, plasmocytes, histocytes and giant cells. This may indicate the development of a cellular type response [3,4,20].…”

Section: Skin Diseasesmentioning

confidence: 99%

Demodex – An Old Pathogen or a New One?

Rusiecka-Ziółkowska¹,

Nokiel²,

Fleischer³

2014

Adv Clin Exp Med

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Demodex was first identified over 150 years ago, but only recently has it attracted wider interest as a contributor to chronic diseases such as acne rosacea or marginal blepharitis. Demodex is commonly found in the human population, in skin sebaceous glands or follicles. The frequency of Demodex infection increases with age, as it is mainly diagnosed after the age of seventy; however, it can sometimes be found in children and teenagers. Demodex is supposed to contribute to the development of marginal blepharitis or acne rosacea, but the pathogenic mechanisms have not yet been explained in detail. These diseases are chronic and the long-term treatment effects are not satisfactory. This paper presents the characteristics of Demodex as well as its prevalence in the pathogenesis of eye and skin diseases, and describes the diagnostics and treatment of these disorders (Adv Clin Exp Med 2014, 23, 2, 295-298).

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Section: Skin Diseasesmentioning

confidence: 99%

Demodex – An Old Pathogen or a New One?

Rusiecka-Ziółkowska¹,

Nokiel²,

Fleischer³

2014

Adv Clin Exp Med

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“…The human hair follicle mites Demodex folliculorum and D. brevis are obligatory commensals of the pilosebaceous unit and the most prevalent ectoparasites (1) Despite their high existence rates, these mites usually do not cause symptoms unless their density is abnormally increased on the skin (i.e., >5 mites per cm²) (2). More importantly, some studies have proposed causative/exacerbating roles for Demodex mites in the pathogenesis of several benign and malignant skin diseases such as rosacea (3), pityriasis (4), skin bacterial infections (5), dermatitis (6) acne vulgaris (7), basal cell carcinoma (BCC), and squamous cell carcinoma (SCC) (8,9).…”

Section: Introductionmentioning

confidence: 99%

“…Akar dansitesi (cm 2 başına) ve enfestasyon (dansite≥5) hasta ve kontrol grubu arasında karşılaştırıldı. Bulgular: Akar enfestasyon hızları (%) kontrol grubu (20,6) ile BCC (22,2, p=0,88), SCC (17,9, p=0,79), melanom (4,3, p=0,08), ve DLE (21,9, p=0,90) hastaları arasında anlamlı bir farklılık göstermedi. Kontrol grubuna kıyasla, akar enfestasyon hızı, rozasea olanlarda anlamlı olarak yüksekti (47,1, p=0,02; odds oranı: 3,43, %95 güven aralığı: 1,18-9,99).…”

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Demodex Mite, Rosacea and Skin Melanoma; Coincidence or Association?

Talghini

Fouladi²,

Babaeinejad³

et al. 2015

TurkiyeParazitolDerg

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Objective: To examine the possible associations between Demodex folliculorum and a number of skin diseases. Methods: Standardized skin surface biopsy samples were obtained from the cheeks of 144 patients with histopathologically proven basal cell carcinoma (BCC, n=27), squamous cell carcinoma (SCC, n=28), melanoma (n=23), discoid lupus erythematosus (DLE, n=32), and rosacea (n=34). Thirty-four sex-and age-matched healthy volunteers served as controls. Mite density (per cm 2 ) and infestation (density≥5) were compared between the controls and patients. Results: Mite infestation rates (%) did not differ significantly between the controls (20.6) and patients with BCC (22.2, p=0.88), SCC (17.9, p=0.79), melanoma (4.3, p=0.08), and DLE (21.9, p=0.90). Compared with the controls, the mite infestation rate was significantly higher in patients with rosacea (47.1, p=0.02, odds ratio: 3.43, 95% confidence interval: 1.18-9.99). The mean mite density did not differ significantly between the controls (4.11±2.17) and patients with BCC (5.34±2.35, p=0.75), SCC (3.57±2.01, p=0.38), and DLE (3.56±1.34, p=0.83), whereas it was significantly higher in patients with rosacea (8.78±3.58, p=0.02) and lower in patients with melanoma (1.89±0.69, p=0.02). Conclusions: D. folliculorum may be associated with rosacea and melanoma but not with BCC, SCC, or DLE. Metot: Standardize yüzeyel deri biyopsisi örnekleri; bazal hücreli karsinom (BCC, n=27), skuamöz hücreli karsinom (SCC, n=28), melanom (n=23), diskoid lupus eritematozus (DLE, n=32), ve rozasea (n=34) tanıları histopatolojik olarak kanıtlanmış 144 hastanın yanaklarından alındı. Cinsiyet ve yaşı eşleştirilmiş 34 sağlıklı gönüllü kontrol grubunu oluşturdu. Akar dansitesi (cm 2 başına) ve enfestasyon (dansite≥5) hasta ve kontrol grubu arasında karşılaştırıldı. Bulgular: Akar enfestasyon hızları (%) kontrol grubu (20,6) ile BCC (22,2, p=0,88), SCC (17,9, p=0,79), melanom (4,3, p=0,08), ve DLE (21,9, p=0,90) hastaları arasında anlamlı bir farklılık göstermedi. Kontrol grubuna kıyasla, akar enfestasyon hızı, rozasea olanlarda anlamlı olarak yüksekti (47,1, p=0,02; odds oranı: 3,43, %95 güven aralığı: 1,18-9,99). Ortalama akar dansitesi kontrol grubu (4,11±2,17) ile BCC (5,34±2,35, p=0,75), SCC (3,57±2,01, p=0,38), ve DLE (3,56±1,34, p=0,83) hasta grupları arasında anlamlı bir fark göstermezken, kontrol grubuna kıyasla

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“…They have been reported to be involved in pityriasis folliculorum (Ayres, 1930), rosacea (Ayres and Ayres, 1961;Bonnar et al, 1993;Forton and Seys, 1993), pustular folliculitis (Dong and Duncan, 2006), papulopustular scalp eruptions (Purcell et al, 1986), perioral dermatitis (Hsu et al, 2009), and blepharitis (Post and Juhlin, 1963;Divani et al, 2009;Zhao et al, 2012). It is also suspected that Demodex infestation may be one of the triggering factors of carcinogenesis in eyelid basal cell carcinomas (Erbagci et al, 2003) and sebaceous adenoma (Dhingra et al, 2009). Moreover, the infestation rate in the immunocompromised population with leucocythemia (Damian and Rogers, 2003) or acquired immune deficiency syndrome (AIDS) (Clyti et al, 2005) is remarkably high and pustular eruption or seborrheic dermatitis becomes even more conspicuous.…”

Section: Introductionmentioning

confidence: 99%

A meta-analysis of association between acne vulgaris and Demodex infestation

Zhao

et al. 2012

J. Zhejiang Univ. Sci. B

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Until now, etiology of acne vulgaris is still uncertain. Although clinicians usually deny the association between Demodex infestation and acne vulgaris, it has been proved in some clinical practices. To confirm the association between Demodex infestation and acne vulgaris, a meta-analysis was conducted. Predefined selection criteria were applied to search all published papers that analyzed the association between Demodex infestation and acne vulgaris (January 1950 to August 2011) in ISI Web of Knowledge, MEDLINE, and China National Knowledge Infrastructure (CNKI) databases. A meta-analysis was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) based on fixed effects models or random effects models. We enrolled the 60 Chinese and 3 English papers in this meta-analysis, which covered Turkey and 25 different provinces/municipalities in China and 42 130 participants including students and residents, aged from 1 to 78 years. The pooled OR in random effects models is 2.80 (95% CI, 2.34-3.36). Stability is robust according to sensitivity analysis. The fail-safe number is 18 477, suggesting that at least 18 477 articles with negative conclusions would be needed to reverse the conclusion that acne vulgaris was related to Demodex infestation. So the effect of publication bias was insignificant and could be ignored. It was concluded that acne vulgaris is associated with Demodex infestation. This indicates that when regular treatments for acne vulgaris are ineffective, examination of Demodex mites and necessary acaricidal therapies should be considered.

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Demodex-associated dermatologic conditions – A coincidence or an etiological correlate. Review with a report of a rare case of sebaceous adenoma

Cited by 21 publications

References 14 publications

Demodex – An Old Pathogen or a New One?

Demodex – An Old Pathogen or a New One?

Demodex Mite, Rosacea and Skin Melanoma; Coincidence or Association?

A meta-analysis of association between acne vulgaris and Demodex infestation

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