Demodex mites of human skin express Tn but not T (Thomsen‐Friedenreich) antigen immunoreactivity

Kanitakis, Jean; al-Rifai, I; Faure, M; Claudy, A

doi:10.1111/j.1600-0560.1997.tb00823.x

Cited by 10 publications

(10 citation statements)

References 6 publications

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“…Tolerogenic dendritic cells may also be induced by the Demodex mite: because Demodex expresses the Tn Ag [147], it is possible that the mite could use this to induce immunotolerance for its own benefit (Fig. 3).…”

Section: Demodex and Immunotolerance: A Role For Vegf And Thomsen-noumentioning

confidence: 99%

“…3). As Demodex mites express the Tn Ag [147], these immune reactions may also occur after contact of mite Tn Ag with dendritic cells.…”

Section: Demodex and Immunotolerance: A Role For Vegf And Thomsen-noumentioning

confidence: 99%

“…IL-10 is thought to induce tolerogenic transformation of the dendritic cell and to stimulate the expression of inhibitory receptors (including programmed death-ligand 1 (PD-L1)) [145]. As Demodex mites express the Tn Ag [147], these immune reactions may also occur after contact of mite Tn Ag with dendritic cells. The peptide Ag (small orange circle) presented by the dendritic cells to the naïve T cell may be another Demodex Ag (exocuticle [239], proteases [167], its endosymbiont Corynebacterium kroppenstedtii [240], etc.)…”

Section: Rosacea: Chronic Demodex Infection With T Cell Exhaustion?mentioning

confidence: 99%

“…3 ). Indeed, the Tn Ag is a precursor of the tumor Thomsen–Friedenreich (T) antigen [ 147 ]. These two antigens are tumor-associated glycan structures, and high expression levels are correlated with poor prognosis and an increased ability of the tumor to metastasize [ 147 , 148 ].…”

Section: Demodex and Immunotolerance: A Role For Vegf And Thmentioning

confidence: 99%

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The Pathogenic Role of Demodex Mites in Rosacea: A Potential Therapeutic Target Already in Erythematotelangiectatic Rosacea?

Forton¹

2020

Dermatol Ther (Heidelb)

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Rosacea is an inflammatory continuum, with all characteristics being already present from the onset of the disease, even if not clinically visible. Demodex proliferation also appears to be a continuum process in rosacea, and high Demodex density is beginning to be accepted as an important trigger of the inflammatory cascade and as a marker of rosacea: moreover, papulopustules of rosacea can be treated using acaricides. Immunological studies are providing new hypotheses according to which Demodex may induce tolerogenic dendritic cells and collaborate with VEGF to induce T cell exhaustion favoring its own proliferation. This proliferation may not be clinically visible initially. The interactions among VEGF, Demodex, and immunity need to be explored, and the nosology of rosacea definitions adapted accordingly. The effectiveness of treating any patient who only has visible vascular symptoms with an acaricidal cream needs to be confirmed in prospective controlled clinical trials with long-term follow-up, but it is already important to detect patients with pityriasis folliculorum among those with only vascular symptoms of rosacea in order to treat at least these patients with an acaricidal cream. DIGITAL FEATURES This article is published with digital features to facilitate understanding of the article. You can access the digital features on the article's associated Figshare page. To view digital features for this article go to

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Section: Demodex and Immunotolerance: A Role For Vegf And Thomsen-noumentioning

confidence: 99%

“…3). As Demodex mites express the Tn Ag [147], these immune reactions may also occur after contact of mite Tn Ag with dendritic cells.…”

Section: Demodex and Immunotolerance: A Role For Vegf And Thomsen-noumentioning

confidence: 99%

Section: Rosacea: Chronic Demodex Infection With T Cell Exhaustion?mentioning

confidence: 99%

Section: Demodex and Immunotolerance: A Role For Vegf And Thmentioning

confidence: 99%

See 2 more Smart Citations

The Pathogenic Role of Demodex Mites in Rosacea: A Potential Therapeutic Target Already in Erythematotelangiectatic Rosacea?

Forton¹

2020

Dermatol Ther (Heidelb)

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show abstract

“…20 21 Recently we found that in adult human skin the T and Tn antigens are expressed within sebaceous (and occasionally sweat) glands and benign proliferations arising from these 21a ); furthermore, demodex mites colonising hair follicles express the Tn (but not the T) antigen. 22 However, normal epidermis and benign epidermal tumours are unreactive. Because of the scarcity of relevant data in published reports, and in view of the potential involvement of T/Tn antigens in carcinogenesis, we screened their expression in primary and metastatic malignancies of the skin.…”

mentioning

confidence: 99%