Demodicosis as treatment complication of amicrobial pustulosis of the folds

Jorge, Marília Formentini Scotton; Miguel, Lívia Maria Zanardi; Braghiroli, Cíntia Santos; Schmitt, Juliano Vilaverde

doi:10.1590/abd1806-4841.20187171

Cited by 7 publications

(4 citation statements)

References 10 publications

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“…Furthermore, German Shepherds are predisposed to primary immunodeficiency (16) and it has been postulated that high microfilaremia might be associated with a state of immunosuppression (17). The chronic yeast infection (usually secondary to an immune disorder in dogs) as well as the appearance of generalized demodicosis are possible indicators of immunodeficiency in this patient (18,19).…”

Section: Discussionmentioning

confidence: 86%

Case Studies of Severe Microfilaremia in Four Dogs Naturally Infected With Dirofilaria repens as the Primary Disease or a Disease Complicating Factor

et al. 2020

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Subcutaneous dirofilariosis in dogs, caused by Dirofilaria repens, is an underdiagnosed disease, now recognized for its zoonotic potential, and growing distribution and prevalence across Europe and Asia. Our understanding of the pathogenicity in human and canine host remains unclear, but case reports suggest that microfilariae (Mf) as well as adult D. repens may directly cause internal organs damage or may be a factor complicating the course of other ailments. The purpose of the study was to report high Mf in dogs and to discuss potential relevance with co-morbidity. Our data from a modified Knott's test performed on 62 infected dogs indicate that the median Mf count in D. repens infections is 675 Mf/ml and we consider microfilaremia above 10,000 Mf/ml as high intensity. This collection of case reports discusses 4 cases of high intensity D. repens microfilaremia in companion dogs; one presenting pathology from a very high intensity of adult D. repens with post-treatment complications, and 3 dogs in which high microfilaremia was detected incidentally during the management of other primary illnesses. To our knowledge this report describes the highest D. repens microfilaremia ever detected in a dog, at 178,000 Mf/ml. The issue of high microfilaremic infections in dogs is poorly studied and there is growing need to identify the presentation and understand the mechanisms of associated pathogenesis in the host-parasite relationship.

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Section: Discussionmentioning

confidence: 86%

Case Studies of Severe Microfilaremia in Four Dogs Naturally Infected With Dirofilaria repens as the Primary Disease or a Disease Complicating Factor

et al. 2020

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“…In addition, inflammation and the development of further complications are often associated with the transmission of bacterial infections, e.g., B. oleronius , S. aureus , or fungal infections carried along with the Demodex spp. [ 127 ]. In demodicosis and rosacea, the importance of the immune response is emphasized.…”

Section: Discussionmentioning

confidence: 99%

Demodicosis in Different Age Groups and Alternative Treatment Options—A Review

Chudzicka-Strugała

Gołębiewska

Brudecki³

et al. 2023

JCM

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Infestation with Demodex mites is a common occurrence, especially in adults and the elderly. More recent attention has been paid to the presence of Demodex spp. mites in children, even ones without comorbidities. It causes both dermatological and ophthalmological problems. The presence of Demodex spp. is often asymptomatic, thus it is suggested to include parasitological investigation tests in dermatological diagnostics, in addition to bacteriological analysis. Literature reports show that Demodex spp. are related to the pathogenesis of numerous dermatoses, including rosacea or demodicosis gravis, and common eye pathologies reported by patients such as dry eye syndrome or ocular surface inflammatory conditions, such as blepharitis, chalazia, Meibomian gland dysfunction, and keratitis. Treatment of patients is a challenge and is usually prolonged, therefore it is important to carefully diagnose and properly select the therapy regimen for the treatment to be successful, and with minimal side effects, especially for young patients. Apart from the use of essential oils, research is ongoing for new alternative preparations active against Demodex sp. Our review was focused on the analysis of the current literature data on the available agents in the treatment of demodicosis in adults and children.

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“…15 The literature describes cases of patients who consulted dermatologists about skin lesions and used various treatments with different groups of drugs, but none of them brought the expected results. 16 This situation is difficult both for the doctor who is trying to prescribe more effective drugs and for the patient who expects visible improvement.…”

Section: Discussionmentioning

confidence: 99%

Primary facial demodicosis as a health problem and aesthetic challenge: A case report

Przydatek‐Tyrajska

Sędzikowska

Bartosik

2020

J of Cosmetic Dermatology

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Colonization of skin by Demodex mites developing as a single facial lesion with a limited range is diagnosed relatively rarely. The presence of this type of skin lesions may hinder and thus delay the diagnostic process and application of appropriate treatment. The persistent cosmetic defect on the face is extremely onerous/embarrassing to the patient and impedes normal functioning. Describe a case of atypical presentation of primary facial demodicosis and its successful treatment. We present a case of a 38‐year‐old patient who consulted an aesthetic medicine doctor about a skin lesion, that is, erythematous‐papular lesion with single pustules persisting for more than half a year around the right eye corner and below the lower eyelid. Previous topical antibiotic treatment has proved ineffective. Diagnosis was targeted at detection of Demodex spp. invasion, which yielded a positive result. Targeted therapy with 1% topical ivermectin was implemented. Complete resolution of the skin lesions was observed after 8.5 weeks of the treatment with no further recurrence. In the case of limited scaly erythematous‐papular skin lesions with single pustules, Demodex mites should be considered as an etiological factor or one of the factors in the case of a mixed‐etiology lesion. A delayed diagnosis of visible lesions on facial skin has a negative impact on patient's well‐being and normal functioning. As diagnosis of primary demodicosis is underestimated, knowledge about this dermatosis and its clinical manifestations should be disseminated among cosmetologists and doctors of various specialties.

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Demodicosis as treatment complication of amicrobial pustulosis of the folds

Cited by 7 publications

References 10 publications

Case Studies of Severe Microfilaremia in Four Dogs Naturally Infected With Dirofilaria repens as the Primary Disease or a Disease Complicating Factor

Case Studies of Severe Microfilaremia in Four Dogs Naturally Infected With Dirofilaria repens as the Primary Disease or a Disease Complicating Factor

Demodicosis in Different Age Groups and Alternative Treatment Options—A Review

Primary facial demodicosis as a health problem and aesthetic challenge: A case report

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