Demographic and Clinical Characteristics of Adult Acute Myeloid Leukemia - Tertiary Care Experience

Sultan, Sadia; Zaheer, Hasan Abbas; Irfan, Syed Mohammed; Ashar, Sana

doi:10.7314/apjcp.2016.17.1.357

Cited by 12 publications

(13 citation statements)

References 19 publications

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“…This nding in our study in accordance with other studies that reported M2 to be the most common subtype in their studies [1,4,20,21] and in contrast to other studies that showed a predominance of M1 in her study [16]. It is reported that different AML subtypes have different prognostic values [22]. FAB subtypes M0, M5, M6, and M7 are associated with the worst prognosis, while M2 and M4 a good prognosis.…”

Section: Discussionsupporting

confidence: 92%

Acute myeloid leukemia among patients at the National Oncology Center in Sana ’ a, Yemen: prevalence, subtypes, and hematological features

Al-Nuzaili

Al-Khamesy

Yahia

2022

Preprint

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Background Acute myeloid leukemia (AML) is a malignant disorder of the myeloid cell lineage within the bone marrow (BM). It is caused by chromosomal abnormalities resulting in the accumulation of myeloblasts within the BM and infiltration of peripheral tissues. The aim of this study was to determine the prevalence, subtypes, and hematological features of AML among patients at the National Oncology Center (NOC) in Sana'a. Methods This retrospectively registered study was carried out on 747 patients diagnosed with hematological malignancies (HMs). It included 472 (63.2%) males and 275 (36.8%) females, aged 1 to 75 years. The registered data was collected from the NOC in Sana'a, Yemen, between March 2020 and May 2022. These patients came to the NOC from different hospitals and clinics in Sana’a as well as from other governorates. The patients came to NOC for a better diagnosis and appropriate treatment. The diagnosis of AML was performed by CBC, Giemsa-stained blood/BM films, and immunophenotypic using flow cytometry to confirm, if necessary, the definitive diagnosis. The SPSS-26 program was used to analyze the data. Results Among 747 patients, there were 175 (23.4%) patients diagnosed with AML. It included 98 (56%) males and 77 (44%) females, ages 1 to 75. Acute leukemia (ALL and AML) and chronic leukemia (CML and CLL) were detected in 543 (79.7%) and 138 (20.3%) patients, respectively. The relative frequencies of leukemia were ALL, AML, CML, and CLL, which were detected in 49.30%, 23.43%, 11.65%, and 6.83% of patients, respectively. FAB-M2 was observed in 48.57% of patients, followed by M5 (17.72%), M1 (15.43%), M3 (11.43%), M4 (5.71%), and the less common M0 (0.57%), M7 (0.57%), and M6 (0%). The hematological features in AML patients include decreased Hb, increased WBC, and decreased platelets in 96.6%, 81.7%, and 100% of patients, respectively. There were significant positive correlations between age and Hb (p = 0.009) and WBC (p = 0.002), and between Hb and WBC (p = 0.001). Conclusion Leukemia was the most common type among hematological malignancies (HMs). ALL and AML constitute approximately a half and a quarter of leukemia. AML-M2 was the most common FAB subtype in half of the AML patients.

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Section: Discussionsupporting

confidence: 92%

Acute myeloid leukemia among patients at the National Oncology Center in Sana ’ a, Yemen: prevalence, subtypes, and hematological features

Al-Nuzaili

Al-Khamesy

Yahia

2022

Preprint

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“…In contrast, this age was lower than that reported in many other studies, which prove the youthful character of the Moroccan AML patients [7-12-23-32-34]. On the other hand study by Sultan et al in the Pakistan population, reported a median age of 37.5 [35] Table 3.…”

Section: Discussionmentioning

confidence: 67%

“…In the study of Padilha et al, patients were predominantly younger than 60 years old (81.6%). Similarly, in the study by Sultan et al 76% of all AML patients ( aged between 15-85) were under 50 years old [35][36]. However, according to SEER statistics patients older than age 65 represent approximately 55% of AML cases [37].This disagreement between studies might be explained by the sample size, the recruitment of pediatric patients, differences in demographic characteristics across countries (the pace of population aging, increased life expectancy…..), environmental and genetic factors which could play a crucial role in the appearance of this cancer at a younger age in our AML patients [38][39].The distribution of the population according to sex revealed a slight male predominance; a similar result was reported in most In AML, leukocytosis is a major prognostic factor.In our series, 13.3% of patients had WBC counts higher than 100.000/mm 3 .…”

Section: Discussionmentioning

confidence: 74%

Characteristics and Survival of 927 Moroccan Adults with Acute Myeloid Leukemia: Monocentric Experience

Boujmia

Lamchahab

Hda

et al. 2021

Asian Pac J Cancer Biol

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Acute myeloïd leukemia (AML) is the most frequent form of acute leukemia among adults and the most aggressive type of leukemia, which is associated with the lowest survival rate. Patients with AML are treated with intensive chemotherapy and many factors could influence the survival of these patients, such as age, cytogenetic abnormalities; white blood cell (WBC) counts. The aim of this work was to study the epidemiological and response profiles of AML adults patients in Morocco.Patients and Methods: A prospective, descriptive study conducted in the Hematology and Pediatric Oncology department, 20 August Hospital Casablanca, and concerned adult patients diagnosed with AML through a period of seven years (January 2011 to December 2017). Statistical analysis was performed using SPSS version 20. The overall survival and disease-free survival were evaluated by using the Kaplan–Meier method. Results: A total of 927 patients diagnosed with AML during the 7 year period. 466 (50.3%) were males and 461 (49.7%) were females. The median age of patients was 46years.The most represented age group was between 18 and 60 years old with a percentage of 83.2%.The FAB subtype M2 occurred most frequently (27%) followed by M1 (24.8%). The cytogenetic study showed that the majority of patients had a normal karyotype. The t (8; 21) was the most detected balanced translocation in our series and the intermediate cytogenetic group was the most represented group (65.4%). A total of 461 patients (53.54%) were treated according to the protocol AML11. The Disease-free survival (DFS) was significantly better for favorable cytogenetic group as compared to other cytogenetic groups (median survival of 41.58 months for the favorable group versus 29.07 months for the adverse group; p-value = 0.02).Conclusion: The age of AML patients was younger compared to other populations. The majority of patients had a normal karyotype and the commonest balanced translocation was the t (8; 21). Survival was higher in patients with good prognosis.

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“…Similar observations have been reported by previously published studies, from Pakistan also revealed comparable age at presentation; 38 and 39 years, respectively. [ 20 21 ]…”

Section: Discussionmentioning

confidence: 99%

Institutional-based tumor registry of hematopoietic malignancies: A 4 years’ preliminary report from Karachi

et al. 2018

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BACKGROUND: Pakistan has a population of over 198 million making it the world’s sixth populous country. However, operational population-based cancer registries in Pakistan are lacking. Limited data are available based on institutional or Karachi Cancer Registry from Karachi; however, no exclusive registry for hematological malignancies is established till date. Hence, we decided to conduct a database analysis to determine the frequencies of various hematological cancers in our tertiary care center in Karachi. PATIENTS AND METHODS: Retrospective assessment of 366 patients presented to Hematology Department, Liaquat National Hospital and Medical College from May 2012 to May 2016 with confirmed diagnosis of hematological cancers was performed. Data were retrieved from hospital-based tumor registry. All pro forma was filled by qualified medical research officer, which included demographic data as age, gender, history, disease type, and its stage at presentation. RESULTS: Male gender was predominant and accounted for 69.9% (n = 256) and female accounted for 30.0% (n = 110) of the total cases with the male-to-female ratio of ~2:1. The mean ages of female and male patients were 42.9 ± 20.7 and 49.7 ± 18.1 years with the median age of 45 and 51.5 years, respectively. In males, the three most frequent malignancies were chronic myeloid leukemia (CML) (16%), acute lymphoblastic leukemia (ALL), and acute myeloid leukemia (AML) (12.8% of each). In females, AML was the most common cancer accounting for 21.8% followed by CML (18.1%) and ALL (10%). CONCLUSIONS: Our institution-based tumor registry indicates CML and AML were the most common cancers in males and females, respectively, followed by ALL. Chronic lymphoid leukemia, unlike in the West, is seen infrequently in our population. National and provisional hematological tumor registry will be beneficial for future health planning and research.

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Demographic and Clinical Characteristics of Adult Acute Myeloid Leukemia - Tertiary Care Experience

Cited by 12 publications

References 19 publications

Acute myeloid leukemia among patients at the National Oncology Center in Sana ’ a, Yemen: prevalence, subtypes, and hematological features

Acute myeloid leukemia among patients at the National Oncology Center in Sana ’ a, Yemen: prevalence, subtypes, and hematological features

Characteristics and Survival of 927 Moroccan Adults with Acute Myeloid Leukemia: Monocentric Experience

Institutional-based tumor registry of hematopoietic malignancies: A 4 years’ preliminary report from Karachi

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