Demographic and clinical features of patients with subacute thyroiditis: Results of 169 patients from a single University Center in Turkey

Erdem, Nihal Zekiye; Erdoğan, Mehmet; Özbek, Mustafa; Karadeniz, Muammer; Çetinkalp, Şevki; Özgen, A. Gökhan; Saygılı, Füsun; Yılmaz, Candeğer; Tüzün, Mehmet; Kabalak, Taylan

doi:10.1007/bf03346347

Cited by 58 publications

(51 citation statements)

References 20 publications

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“…Classically the patient presents with thyrotoxicosis and severe pain in thyroid region that follows a course of hypothyroidism and eventually to euthyroidism (1)(2)(3). However, atypical presentations such as painless nodular goiter have been described (4,5).…”

Section: Introductionmentioning

confidence: 96%

A Case of Subacute Thyroiditis in the First Trimester of Pregnancy

Kaykhaei¹

2012

Acta Endo (Buc)

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Background. Thyroid dysfunction during pregnancy may adversely affect mother and fetus. A number of disorders have been described as a cause of thyrotoxicosis in pregnancy. Subacute thyroiditis is a rare cause of thyrotoxicosis in pregnant women. Although self limited, due to both hyper-and subsequent hypothyroidism, this disorder may have deleterious effects in outcome of pregnancy.Case report.A 29 year old woman in the first trimester of pregnancy was referred due to palpitation, malaise and pain in thyroid region. Laboratory data revealed a suppress TSH, elevated Free T4 and high ESR. Pregnancy test was positive. Diagnosis of subacute thyroiditis was made by Doppler sonography of thyroid. A dramatic response to prednisolone was observed. Two months later because of hypothyroidism, levothyroxine was started and continued throughout pregnancy. She delivered a healthy baby at term without complication.Conclusions. Although subacute thyroiditis is rare during pregnancy, its possibility should be kept in mind in hyperor hypothyroid pregnant women.

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Section: Introductionmentioning

confidence: 96%

A Case of Subacute Thyroiditis in the First Trimester of Pregnancy

Kaykhaei¹

2012

Acta Endo (Buc)

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“…The disease rarely occurs in children, with previous reports involving children aged 1.7-10 years [1,7,17,20,28,32,36,43]. Female is more likely to be affected, with the female to male ratio of 4-7:1 [5,13,23]. Previous studies [23,27,30] reported an increased incidence during summer, but other studies did not show a seasonal trend [4,15].…”

Section: Clinical Presentationmentioning

confidence: 80%

“…The overall age-and sex-adjusted incidence rate from the Olmsted County, Minnesota study which involved 94 patients from 1970 to 1997, aged 14-87 years, was reported at 4.9 cases per 100,000/year [15]. Peak incidence of the disease is in the fourth and fifth decades of life [13,15,30]. The disease rarely occurs in children, with previous reports involving children aged 1.7-10 years [1,7,17,20,28,32,36,43].…”

Section: Clinical Presentationmentioning

confidence: 82%

“…Epidemiology de Quervain thyroiditis is the most common cause of painful thyroid disease in adults which may account for up to 5% of adult thyroid diseases [13], but data on its prevalence in children are lacking. The overall age-and sex-adjusted incidence rate from the Olmsted County, Minnesota study which involved 94 patients from 1970 to 1997, aged 14-87 years, was reported at 4.9 cases per 100,000/year [15].…”

Section: Clinical Presentationmentioning

confidence: 99%

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Eponym

Engkakul

Mahachoklertwattana²,

Poomthavorn³

2010

Eur J Pediatr

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de Quervain thyroiditis is a self-limited inflammatory disorder of the thyroid gland. It is an uncommon disease in adults and very rare in children. Fritz de Quervain, a Swiss surgeon, who was an authority on thyroid disease, described the unique pathology of this disease. Granulomatous changes with giant cells in thyroid tissue are the pathological findings. Viral infection in genetically predisposed individuals has been proposed as the pathogenesis of the disease. Clinical hallmarks for the diagnosis are painful thyroid enlargement, elevated erythrocyte sedimentation rate, and C-reactive protein as well as decreased uptake of the thyroid gland on thyroid scintigraphy. In addition, thyrotoxicosis is present in about 50% of cases in early phase of the disease. Serum thyroglobulin level is usually elevated. Only symptomatic treatment with analgesics is usually required for pain relief. Glucocorticoid therapy may be used in severely ill patients. de Quervain thyroiditis is generally completely resolved without complications in 6-12 months. However, permanent hypothyroidism and recurrent disease have been reported in some patients.

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“…Recurrent de Quervain thyroiditis is uncommon and usually occurs within 1 year after the diagnosis [4,5]. However, late recurrence after several years has also been reported [5].…”

Section: Discussionmentioning

confidence: 96%

de Quervain thyroiditis in a young boy following hand–foot–mouth disease

2010

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de Quervain thyroiditis, also known as subacute thyroiditis, is a self-limited inflammatory disease of the thyroid gland. It is extremely rare in children. The hallmarks for diagnosis are painful thyroid enlargement, elevated inflammatory markers, and decreased uptake of the thyroid gland on thyroid scintigraphy. Viral infection has been proposed to be associated with de Quervain thyroiditis. Coxsackie virus has been reported to be one of the viruses associated with the disease. To our knowledge, childhood de Quervain thyroiditis associated with hand-foot-mouth disease caused by coxsackie infection has never been reported. We report a 2.7-year-old boy who presented with typical features of de Quervain thyroiditis following hand-foot-mouth disease caused by coxsackie B4 infection. He had a brief thyrotoxic phase initially, followed by transient hypothyroid phase and euthyroidism thereafter. His thyroid scintigraphy showed a typical faint uptake at the diagnosis, and an improvement of the thyroid scan and uptake was shown 8 weeks later. He was treated with prednisolone and nearly complete resolution was documented within 2 months. Careful evaluation of the patient led to the correct diagnosis and appropriate management.

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Demographic and clinical features of patients with subacute thyroiditis: Results of 169 patients from a single University Center in Turkey

Abstract: With the exception of ESR, demographic, clinical, laboratory, and imaging findings and prognoses of our patients were comparable to the previous reports.

Cited by 58 publications

References 20 publications

A Case of Subacute Thyroiditis in the First Trimester of Pregnancy

A Case of Subacute Thyroiditis in the First Trimester of Pregnancy

Eponym

de Quervain thyroiditis in a young boy following hand–foot–mouth disease

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