Demographic and clinicopathological characteristics of nasopharyngeal carcinoma and survival outcomes according to age at diagnosis: A population-based analysis

Practice patterns and outcomes of chemoradiotherapy versus radiotherapy alone for older patients with nasopharyngeal cancer

“…Furthermore, there were only three variables significantly different between groups on multivariable logistic regression analysis (age, gender, and nodal status); of those three variables, the CRT cohort was younger but had a higher proportion of node‐positive disease and males. Younger age has been shown to associate with more advanced disease ; node‐positivity and male gender also correlate with poorer prognosis . In this manner, consistent with other work, it is plausible that chemotherapy potentially may have been given to a “higher‐risk” population, and that there may be “true” benefits to adding chemotherapy .…”

Impact of age on survival of locoregional nasopharyngeal carcinoma: An analysis of the Surveillance, Epidemiology, and End Results program database, 2004‐2013

“…The expansive coverage of the SEER program, which includes almost one‐third of the US population, has made it a valuable source of data for analyses of racial differences in the outcomes of patients with uncommon cancers such as NPC . Our findings of racial differences in risk of death for patients with NPC add to a growing body of literature that is providing important insight into this rare cancer.…”

“…Studies by Richey et al and Sultan et al over ten years ago discovered that young black people had a higher incidence rate of NPC than did whites or Asians 55,56. Wu et al confirmed the high proportion of black patients among younger people with NPC 51. Richey and colleagues also reported that young patients comprised almost one-third of all black patients with type III (now type IIb) NPC, but they comprised less than 15% of white patients and <10% of Asian patients 55.…”

Competing risk nomograms for nasopharyngeal carcinoma in the intensity-modulated radiotherapy era: A big-data, intelligence platform-based analysis

“…Previous studies have also reported that increasing age is associated with poor survival in NPC patients, although they analyzed overall survival rather than cause-specific mortality [24][25][26]. One study based on the Surveillance, Epidemiology, and End Results database revealed that older age was predictive of NPC-SM, using the Cox method without assessing OCSM [27]. These studies hardly evaluated the exact impact of age on NPC-SM and OCSM, which may have biased their results, leading to over-or undertreatment.…”