Background
Randomized trials demonstrate clear benefits of mammography screening in women through age 74 years. We explored age- and race-specific rates of mammography screening and breast cancer mortality among women ages 69 to 84 years.
Methods
We analyzed Medicare claims data for women residing within Surveillance, Epidemiology and End Results (SEER) geographic areas from 1995 to 2009 from 64,384 non-Hispanic women (4,886 black and 59,498 white) and ascertained all primary breast cancer cases diagnosed between ages 69 and 84 years. The exposure was annual or biennial screening mammography during the four years immediately preceding diagnosis. The outcome was breast cancer mortality during the ten years immediately following diagnosis.
Results
After adjustment for stage at diagnosis, radiation therapy, chemotherapy, co-morbid conditions and contextual socio-economic status, hazard ratios (HR’s) (and 95% confidence intervals) for breast cancer mortality relative to no/irregular mammography at 10 years for women ages 69–84 years at diagnosis were 0.31 (0.29–0.33) for annual and 0.47 (0.44–0.51) for biennial mammography among whites and 0.36 (0.29–0.44) for annual and 0.47 (0.37–0.58) for biennial mammography among blacks. Trends were similar at five years overall as well as stratified by ages 69–74, 75–78, and 79–84.
Conclusions
In these Medicare claims and SEER data, elderly non-Hispanic women who self-selected for annual mammography had lower ten-year breast cancer mortality than corresponding women who self-selected for either biennial or no/irregular mammography. These findings were similar among black and white women. The data highlight the evidentiary limitations of data used for current screening mammography recommendations.