Demographic and Lifestyle Factors Associated with Dioxin-like Activity (CALUX−TEQ) in Human Breast Milk in Hong Kong

Nelson, E. A. S.; Hui, Lucas Chi Kwong; Wong, Tze-Wai; Hedley, A. J.

doi:10.1021/es052164r

Cited by 14 publications

(4 citation statements)

References 37 publications

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“…All analyses used wet-weight concentrations. Adjusted models included age (in years), breast-feeding history (conditional categorical), BMI (continuous), and cotinine (continuous) (Hediger et al 2005; Nelson et al 2006; Sasamoto et al 2006; Zeyneloglu et al 1997). Serum lipids (milligrams per deciliter) were also entered into serum models to minimize potential biases associated with automatic lipid adjustment (Schisterman et al 2005).…”

Section: Methodsmentioning

confidence: 99%

Persistent Lipophilic Environmental Chemicals and Endometriosis: The ENDO Study

Louis

Chen

Peterson³

et al. 2012

Environ Health Perspect

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Background: An equivocal literature exists regarding the relation between persistent organochlorine pollutants (POPs) and endometriosis in women, with differences attributed to methodologies.Objectives: We assessed the association between POPs and the odds of an endometriosis diagnosis and the consistency of findings by biological medium and study cohort.Methods: Using a matched cohort design, we assembled an operative cohort of women 18–44 years of age undergoing laparoscopy or laparotomy at 14 participating clinical centers from 2007 to 2009 and a population-based cohort matched on age and residence within a 50-mile catchment area of the clinical centers. Endometriosis was defined as visualized disease in the operative cohort and as diagnosed by magnetic resonance imaging in the population cohort. Logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for each POP in relation to an endometriosis diagnosis, with separate models run for each medium (omental fat in the operative cohort, serum in both cohorts) and cohort. Adjusted models included age, body mass index, breast-feeding conditional on parity, cotinine, and lipids.Results: Concentrations were higher in omental fat than in serum for all POPs. In the operative cohort, γ-hexachlorocyclohexane (γ-HCH) was the only POP with a significant positive association with endometriosis [per 1-SD increase in log-transformed γ-HCH: adjusted OR (AOR) = 1.27; 95% CI: 1.01, 1.59]; β-HCH was the only significant predictor in the population cohort (per 1-SD increase in log-transformed β-HCH: AOR = 1.72; 95% CI: 1.09, 2.72).Conclusions: Using a matched cohort design, we found that cohort-specific and biological-medium–specific POPs were associated with endometriosis, underscoring the importance of methodological considerations when interpreting findings.

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Section: Methodsmentioning

confidence: 99%

Persistent Lipophilic Environmental Chemicals and Endometriosis: The ENDO Study

Louis

Chen

Peterson³

et al. 2012

Environ Health Perspect

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“…Previous studies associated with the occurrences and profiles of PCBs, PCDDs and PCDFs in Hong Kong have focused on marine sediment, the atmosphere, biota and human breast milk (Choi et al 2008;Hedley et al 2006;Kang et al 2011;Kueh and Lam 2008;Louie and Sin 2003;Nelson et al 2006;Wong et al 2013). There is still little available information on PCBs, PCDDs and PCDFs in the soils of Hong Kong.…”

Section: Concentrations Of Pcns Pcbs Pcdds and Pcdfsmentioning

confidence: 99%

Occurrence, profile and possible sources of PCNs in Hong Kong soils, and a comparison with PCBs, PCDDs and PCDFs

Liu

Cai

2014

Environ Sci Pollut Res

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Polychlorinated naphthalenes (PCNs) have been proposed for inclusion in the annexes of the Stockholm Convention by the European Union, signifying a probable increase in monitoring PCN levels at a global level. Investigations on PCN levels in the environment of Hong Kong have not been reported. In this preliminary investigation, PCN levels in surface soils samples were determined by isotope dilution HRGC/HRMS techniques, and compared with those of polychlorinated biphenyl (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs). The concentrations of PCNs in the soil samples were 35-883 pg g −1 (average, 201; and median, 94 pg g), which were lower than those of PCBs PCDDs and PCDFs. This comparison suggested that PCNs are currently not priority POPs compared with dioxins and PCBs in Hong Kong soils. PCDDs were the most important contributor to the sum of toxic equivalents of PCNs, PCBs, PCDDs and PCDFs. OCDD was the most dominant dioxin congener in Hong Kong surface soils. PCB-118 was the most abundant in 12 dl-PCB congeners. PCN congeners indicating thermal related sources (CN52/60, CN66/67 and CN73) were relatively abundant in their respective homologs, which suggested PCN contamination from thermal sources. The ratio of CN73 to CN74 in soil samples suggested the contribution of PCN contaminations in soils from both thermal-related sources and evaporative emissions of technical PCN mixtures.

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“…This bioassay, which measures AhR-mediated chemical-activated luciferase gene expression (CALUX) has been widely adopted to evaluate the effects of dioxin-like compounds in environmental samples, such as biota (Khim et al, 2000), sediment (Khim et al, 1999) and human milk (Nelson et al, 2006). Furthermore, the US EPA approved the CALUX bioassay as an alternate dioxin test (Method 4435) in February 2008(US EPA, 2008.…”

Section: Introductionmentioning

confidence: 99%