Demographic Characteristics and Lifestyle Habits of Chinese Plasma Donors: A Multicenter Study

Sun, Pan; Zhang, Wei; Du, Xi; Zhu, Liyuan; Xu, Jun; Cheng, Lu; Zhou, Xuefeng; Shi, Zhihui; Liu, Yeheng; Xie, Tianfa; Liao, Zhijun; Qin, Liping Jessica; Zhang, Pengfei; Su, Wu; Zhang, Xingfei; Wei, Qiongshu; Liu, Bin; Liu, Fengjuan; Li, Changqing; Ye, Shengliang; Zhang, Yamei; Ma, Li

doi:10.12659/msm.931471

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…Notably, the majority (60%) had a donation history of at least five years. 17 These data are quite different from those of US plasma donors.…”

Section: Discussionmentioning

confidence: 79%

“…16 There is an urgent need for countries outside of the US to attempt to increase their own source plasma production. 5,17 In addition, US plasma manufacturers must recover from the dramatic challenges of the COVID-19 pandemic. We believe that increased information regarding pre-pandemic donor demographics would help to serve as a baseline for evaluation of post-pandemic practices.…”

Section: Introductionmentioning

confidence: 99%

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A Retrospective Study Establishing Pre-Pandemic Demographic Baselines for United States Source Plasma Donors

Rosa-Bray¹,

Bounpheng²,

Wisdom³

et al. 2022

Clin Med�Insights�Blood�Disord

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Background The COVID-19 pandemic highlighted plasma as a strategic resource with continually increasing demand. Demographic data for plasma donors are limited compared with blood donors. Increased information regarding pre-pandemic donor demographics may serve as a baseline for evaluation of post-pandemic practices. OBJECTIVES This study asked the question, “What were the demographics of source plasma donors in the US compared to the general population and how did these change over a five-year period preceding the pandemic?” STUDY DESIGN Donor demographic data were retrospectively analyzed for the years 2014, 2016 and 2018 from a network of US plasma centers. METHODS Routine demographic data obtained prior to source plasma collection from all plasma donors at Grifols US centers were retrospectively analyzed. Donor screening and eligibility requirements were standardized across all donor sites and met all donor eligibility requirements (Code of Federal Regulations: 21 CFR part 600). During each calendar year, only data from the first donation in that year were included with each cohort year. RESULTS This study included 1,303,049 unique donors. Donors were predominantly young adult males, although females increased from 37.4% to 41.6%. Caucasians constituted the highest proportion, followed by African American and Hispanic donors. Demographics were generally stable, but the 2018 cohort and the US population exhibited significantly different age, race/ethnicity, and sex profiles. Of 2014 donors, 9.0% returned in all three years studied (2014-2016-2018), with a higher return rate of 16.0% observed for donors returning in just two of the years (2014-2016). Multiyear donors were predominantly male and African American. CONCLUSION US plasma donor demographics over a five-year period (2014-2018) showed generally consistent characteristics but differed from the general US population. Multiyear donors were demographically distinct from single-year donors. These data serve as a snapshot of the US source plasma donor base prior to the COVID-19 pandemic.

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“…Notably, the majority (60%) had a donation history of at least five years. 17 These data are quite different from those of US plasma donors.…”

Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

A Retrospective Study Establishing Pre-Pandemic Demographic Baselines for United States Source Plasma Donors

Rosa-Bray¹,

Bounpheng²,

Wisdom³

et al. 2022

Clin Med�Insights�Blood�Disord

View full text Add to dashboard Cite

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“…In other studies, about 30% of 18 to 30 year-old donors had detectable IgG, while about 60% of 50 year-old donors were seropositive ( Zaaijer, Koppelman & Farrington, 2004 ). A study in our laboratory on the characteristics of Chinese plasma donors showed that most plasma donors (78.5%) were aged 46–55 years old ( Sun et al, 2021 ). This may explain the prevalence of B19V-specific IgG in Chinese plasma donors.…”

Section: Discussionmentioning

confidence: 99%

Parvovirus B19 DNA and antibodies in Chinese plasma donors, plasma pools and plasma derivatives

Sun

Jiang

Liu

et al. 2023

PeerJ

Self Cite

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Background Human parvovirus B19 (B19V) is a common contaminant found in plasma pools and plasma derivatives. Previous studies were mainly focused on limited aspects, further assessment of prevalence of B19V DNA and antibodies in plasma donors, the contamination of B19V in pooled plasma and plasma derivatives should be performed in China. Study Design and Methods Individual plasma donors’ samples from four provinces and pooled plasma from four Chinese blood product manufacturers were collected and screened using B19V DNA diagnostic kits between October 2018 and May 2020. The positive samples were investigated for the seroprevalence of B19V antibodies and subjected to sequence analysis and alignment for phylogenetic studies. Moreover, 11 plasma donors who were B19V DNA-positive at their first testing were also followed during the later donation period. Additionally, 400 plasma pools and 20 batches of plasma derivatives produced by pooled plasma with a viral load of B19V DNA exceeding 104IU/mL were also collected and tested for B19V DNA and antibodies. Objectives To comprehensively and systematically determine the frequency and viral load of B19V DNA in plasma donors, pooled plasma, and plasma derivatives from four Chinese blood product manufacturers. Results A total of 17,187 plasma donors were analyzed and 44 (0.26%) specimens were found positive for B19V DNA. The quantitative DNA levels ranged from 1.01 × 101 to 5.09 × 1012 IU/mL. Forty-four DNA-positive specimens were also investigated for the seroprevalence of B19V antibodies, 75.0% and 2.3% of which were seropositive for B19V IgG and IgM antibodies, respectively. The phylogenic analyses showed that the prevalent genotypes in the four provinces’ plasma donors belonged to B19V Genotype 1. Eleven individual plasma donors who were B19V DNA-positive at the first donation were then followed for a period, and in general, the DNA levels of B19V gradually decreased. Moreover, 64.8% (259/400) of the pooled plasma was contaminated by B19V, with concentrations of 1.05 × 100–3.36 × 109IU/mL. Approximately 72.6% of the DNA-positive plasma pools were only moderately contaminated (<104 IU/mL), while 27.4% contained >104 IU/mL. Twenty batches of plasma derivatives produced by pooled plasma with a viral load of B19V DNA exceeding 104IU/mL were also tested. B19V was detected in 5/5 PCC samples and 5/5 factor VIII samples but was not found in the intravenous immune globulin and albumin samples. Conclusion The contamination of B19V in pooled plasma and plasma-derived clotting factor concentrates is serious. Whether B19V nucleic acid testing (NAT) screening of plasma and plasma derivatives is launched in China, blood product manufacturers should spontaneously perform B19V NAT screening in plasma donors and mini-pool plasma. These measures can ensure that samples with high titer B19V DNA are discarded in order to prevent and control this transfusion transmitted virus.

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“…China's plasmapheresis stations are primarily located in rural areas where the female population significantly outnumbers the male population, with female plasma donors outnumbering male donors by a factor of 2.4 [36]. Consequently, the majority of China's IVIG raw plasma is sourced from female donors.…”

Section: Introductionmentioning

confidence: 99%

Study on the Treatment of ITP Mice with IVIG Sourced from Distinct Sex-Special Plasma (DSP-IVIG)

Zhang,

Yuan,

Wang

et al. 2023

IJMS

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Intravenous immunoglobulin (IVIG) is a first-line drug prepared from human plasma for the treatment of autoimmune diseases (AIDs), especially immune thrombocytopenia (ITP). Significant differences exist in protein types and expression levels between male and female plasma, and the prevalence of autoimmune diseases varies between sexes. The present study seeks to explore potential variations in IVIG sourced from distinct sex-specific plasma (DSP-IVIG), including IVIG sourced from female plasma (F-IVIG), IVIG sourced from male plasma (M-IVIG), and IVIG sourced from a blend of male and female plasma (Mix-IVIG). To address this question, we used an ITP mouse model and a monocyte–macrophage inflammation model treated with DSP IVIG. The analysis of proteomics in mice suggested that the pathogenesis and treatment of ITP may involve FcγRs mediated phagocytosis, apoptosis, Th17, cytokines, chemokines, and more. Key indicators, including the mouse spleen index, CD16+ macrophages, M1, M2, IL-6, IL-27, and IL-13, all indicated that the efficacy in improving ITP was highest for M-IVIG. Subsequent cell experiments revealed that M-IVIG exhibited a more potent ability to inhibit monocyte phagocytosis. It induced more necrotic M2 cells and fewer viable M2, resulting in weaker M2 phagocytosis. M-IVIG also demonstrated superiority in the downregulation of surface makers CD36, CD68, and CD16 on M1 macrophages, a weaker capacity to activate complement, and a stronger binding ability to FcγRs on the THP-1 surface. In summary, DSP-IVIG effectively mitigated inflammation in ITP mice and monocytes and macrophages. However, M-IVIG exhibited advantages in improving the spleen index, regulating the number and typing of M1 and M2 macrophages, and inhibiting macrophage-mediated inflammation compared to F-IVIG and Mix-IVIG.

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Demographic Characteristics and Lifestyle Habits of Chinese Plasma Donors: A Multicenter Study

Cited by 4 publications

References 18 publications

A Retrospective Study Establishing Pre-Pandemic Demographic Baselines for United States Source Plasma Donors

A Retrospective Study Establishing Pre-Pandemic Demographic Baselines for United States Source Plasma Donors

Parvovirus B19 DNA and antibodies in Chinese plasma donors, plasma pools and plasma derivatives

Study on the Treatment of ITP Mice with IVIG Sourced from Distinct Sex-Special Plasma (DSP-IVIG)

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