Demographic, clinical and laboratory characteristics of adult-onset minimal change disease in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Group

Abstract

Background: In our study, diagnostic and demographic characteristics of patients diagnosed with minimal change disease (MCD) by biopsy, clinical and laboratory ndings in our country were investigated.Methods: Data were obtained from the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group database. Demographic characteristics, indications for biopsy, diagnosis of the glomerular diseases, comorbidities, laboratory and biopsy ndings of all patients were recorded. The data presented is cross-sectional and includes application data for the biopsy period.Results: Of 3875 patients, 233 patients with MCD (median age 35.0 years) were included in the study, which constitutes 6.0% of the total glomerulonephritis database. Renal biopsy was performed in 196 (84.1%) patients due to nephrotic syndrome. Median serum creatinine was 0.7(0.6-1.0)mg/dl, mean eGFR was 104±33ml/min/1.73m2 and median proteinuria 6000 mg/day. The number of patients under the age of 40 years was 139 (59.7%) (Group A), and the number of patients aged 40 years and over was 94 (40.3%) (Group B). Compared to Group A, global sclerotic glomeruli (24 vs. 43,p<0.001) interstitial in ammation (15 vs. 34,p<0.001), interstitial brosis (20 vs. 31,p=0.001, vascular changes (10 vs. 25,p<0.001) and tubular atrophy (18 vs. 30,p<0.001) were found to be signi cantly higher in Group B.There was no difference in immuno uorescent staining properties between the two groups.Conclusion: Our data are generally compatible with the literature. Chronic histopathological changes were more common in patients aged 40 years and older than younger patients. Studies investigating the effects of these different features on renal survival are needed.