Children and adolescents are using screen media, which include devices such as cell phones, tablets, computers, and televisions, more than ever before. Much research has examined the impact of screen use on obesity, physical activity, and sedentary behavior as well as sleep and eye strain. In this chapter, we focus on the ways in which the use of screens can lead to physical injuries, including orthopedic issues, for children and adolescents through four distinct mechanisms. One focuses on the ways in which devices themselves can lead to injury (e.g., a television tipping over). Another explains how screen use can cause distractions leading to physical injury, whereas the third addresses overuse. Finally, the fourth mechanism considers the role of media effects. We present a brief overview about each of these four mechanisms, offer important research questions to address going forward, and identify recommendations for key audiences. Continuing research on injuries and orthopedic health from screen use is vital, as it refines recommendations and fosters innovative solutions. At the same time, stakeholders, including researchers, industry professionals, and parents, must stay alert to the evolving risks posed by new devices.