Demographic, Epidemiologic and Clinical Analyses of Paediatric Patients Hospitalized with Henoch-Schonlein Purpura: A Retrospective Study

Abstract

This vasculitis is described by the triad of palpable purpura, abdominal pain, and arthritis. Purpuric skin lesions are the most common clinical findings in HSP followed by joint, gastrointestinal tract, and kidney involvement. ABS TRACTAim: Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis in children. The purpose of this study was to assess the clinical, epidemiological, and laboratory features of 117 children diagnosed with HSP.Materials and Methods: This study was conducted to evaluate the data of 117 children with HSP, retrospectively. The presence of the cardinal clinical findings such as purpura, abdominal pain, and arthralgia; and the presence of increased erythrocyte sedimentation rate, decreased serum C3 levels, leukocytosis, blood in the stool, haematuria, and proteinuria were assessed in children with HSP.Results: Of the 117 patients enrolled in the study, 68 were males (58.1%) and 49 were females (41.9%). The median age was 85 (49) months. Purpuric skin lesions were detected in ninety-eight (97.9%) patients, arthritis/arthralgia in 71 (60.6%), gastrointestinal involvement in 52 (44.4%), and renal involvement in 27 (23%) patients. The median duration of hospitalization day was 6 (10) days. Non-palpable purpuric skin lesions mostly located on ankles were the most common involvement in the patients. Conclusion:Non-palpable purpuric skin lesions were the most common presentations followed by arthritis/arthralgia, and gastrointestinal involvement in our patients. Seasonal distributions, gender, and ages of the patients were concluded to be noncontradictory compared with the literature. Although variable clinical findings in the patients were found, the cardinal features of HSP were determined in almost all subjects in this study.

Impact of the COVID-19 pandemic on the frequency of the pediatric rheumatic diseases

“…In the pandemic period, the number of newly diagnosed IgAV patients significantly decreased as well. Preceding infections, especially upper respiratory tract infections, are reported in approximately 50% of children with IgAV [ 31 , 32 ]. Thus, the decrease in the frequency of upper respiratory tract infections other than COVID-19 due to pandemic restrictions could be the primary reason for the decrease in the diagnostic rate of IgAV.…”

Effect of Running Exercise on Brain Functional Magnetic Resonance Characteristics of College Students with Depression

“…At the same time, an fMRI study of adolescent depression found that the limbic system-pallidal-thalamic circuit has abnormal brain functional activity [ 9 , 10 ]. However, it has not been found that NLE can cause abnormal brain function in adolescents with MDD [ 11 ]. Therefore, whether NLE is an influencing factor of abnormal brain activity in adolescent MDD patients, the result is unknown and needs to be further explored.…”

Evaluation of the Effect of the Pandemic Period on Henoch-Schönlein Purpura

“…In a study by Akça et al [25], in which they determined the COVID-19 pandemic period between March 2020 and February 2021; the effect of the COVID-19 pandemic period on the frequency of newly diagnosed patients in pediatric rheumatology was examined, and it was found that there were significant decreases in the number of patients during the COVID-19 pandemic compared to the previous four years. In the study by Gökçe et al [26], approximately 50% of the children diagnosed with IgAV had a previous history of upper respiratory tract infection, and significant decreases were observed in the number of newly diagnosed IgAV patients during the pandemic period. In a study conducted in Singapore in 2020 comparing the indicators of flu activity before and after public health efforts to control COVID-19 infection;…”