Demographic pattern of chronic lymphocytic leukemia in a tertiary hospital in Calabar, South-South Nigeria

Akaba, Kingsley; Enang, Ofem; Igwilo, Hilary; Eduve, Victor; Akaba, Edakabasi; Cletus, Omini; Oshatuyi, Olukayode

doi:10.4103/aam.aam_60_19

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…A similar study on the pattern and prevalence of haematological cancers in South-Eastern Nigeria also reported a prevalence of 12.6% [5]. The chronic myeloid leukaemia is said to affect any age group but is rare in children [2,3]. The median ages vary from one location to another.…”

Section: Introductionmentioning

confidence: 90%

“…This is caused by the BCR-ABLI, a chimeric protein which is the result of the reciprocal translocation [t (9, 22) (q34: q11)] which is cytogenetically represented as Philadelphia chromosome (ph) [1,2]. Chronic myeloid leukaemia is a rare disease condition, with an incidence of one to two cases per 100,000 people per year and accounts for 15% of adult leukaemia and 15.97% of leukaemia globally [3]. In a previous study [4], the prevalence of CML was reported as 19.57%.…”

Section: Introductionmentioning

confidence: 99%

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Demographics and Overall Survival Pattern of Chronic Myeloid Leukemia in a Tertiary Hospital in South-South Nigeria: The Calabar Experience

Akaba

Inyama

Kokelu

et al. 2022

ARRB

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Background: Chronic myeloid leukemia (CML) is a bi- or triphasic disease comprising of the chronic phase (present at diagnosis in approximately 85% of patients) which can easily be controlled with conventional chemotherapy, followed by unstable accelerated phase and terminating in a blastic phase. The treatment of CML has evolved over the years The availability of the tyrosine kinase inhibitors has distinctly changed the disease course for patients with Ph+ and/or BCR-ABL1+ (CML). This study aims to determine the demographics and overall survival patterns of CML patients in the University of Calabar Teaching Hospital (UCTH)l. Methods: The study is a retrospective study of twenty-two (22) CML patients seen and managed at the UCTH from June 2014 to August 2021. Male/female distribution was 9/13, with a median age of 42 years. Overall survival (OS) and progression free survival (PFS) were determined using the Kaplan-Meier techniques. The data were analyzed using Microsoft Excel 2016 and IBM SPSS version 21. Results: Total of 22 CML patients were seen over the 8-year-period of review. The mean age was 42.63, median age 42, and modal age was 37 years respectively. There were 9 males and 13 females. 20 of the patients were in the chronic phase while 2 were in the terminating blastic phase. The presence of mutation was seen in two patients while the remaining 20 showed no mutation. Of the patients, 6 were dead and 16 are alive at the time of review. The overall survival period ranges from 12 to 84 months. The survival distributions for mutation and state of the disease (chronic or blastic) were not statistically significantly different, X2= 3.204, p = 0.073. Conclusion: There is inconsistency in the demographic and overall survival pattern of chronic myeloid leukaemia in our environment. Further study is needed to identify the factors which can help to improve the overall survival pattern in our environment.

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Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Demographics and Overall Survival Pattern of Chronic Myeloid Leukemia in a Tertiary Hospital in South-South Nigeria: The Calabar Experience

Akaba

Inyama

Kokelu

et al. 2022

ARRB

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Comparative study of hemostasis file in newly diagnosed leukemia patients and healthy persons at the Hematology and Blood Transfusion Department, National Hospital, Abuja

Yashim,

Obazee,

Ajani

et al. 2022

BLDE University Journal of Health Sciences

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BACKGROUND: Hemostasis is a complicated and multifaceted condition that often leads to the stoppage of bleeding from injuries. At presentation, blood coagulation irregularities are common in patients with acute leukemia. AIM AND OBJECTIVE: This study aimed to compare hemostasis profiles of newly diagnosed leukemia patients with healthy persons. METHODOLOGY: This is a cross-sectional study carried out at the Hematology and Blood Transfusion Department of the National Hospital Abuja, Nigeria, from June 2018 and May 2020 among 30 newly diagnosed leukemia patients and 30 healthy persons. Complete blood counts, platelets, hemoglobin, total white blood count, packed cell volume prothrombin time (PT), activated partial thromboplastin time (APTT), erythrocyte sedimentation rate (ESR), and fibrinogen were assayed on patients' venous blood using the standard methods. Data analysis was done using software IBM-SPSS version 25. Associations between the variables were determined using Student's t-test taking a P < 0.05 as significant. RESULTS: The mean and median age of the leukemia patients was 45.8 ± 10.73 and 41 years, respectively. The mean value of PT (21.2 ± 0.9 seconds) and APTT (39.0 ± 1.4 seconds) was raised significantly (P < 0.001) in leukemia patients than in control (4.8 ± 0.3 s) and (13.9 ± 0.3 s). The mean value of ESR among leukemia patient was 41.7 ± 4.6 mm/h, while it was 29.6 ± 0.4 mm/h in control (P < 0.001). Mean value of fibrinogen reduced significantly 181.9 ± 3.70 mg/dl in leukemia patients as compared to control 261.6 ± 5.21 mg/dl (P < 0.001). CONCLUSION: This study found significant differences in hematological and hemostasis profiles levels between leukemia and healthy persons, which shows the presence of inflammation.

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Demographic pattern of chronic lymphocytic leukemia in a tertiary hospital in Calabar, South-South Nigeria

Cited by 2 publications

References 11 publications

Demographics and Overall Survival Pattern of Chronic Myeloid Leukemia in a Tertiary Hospital in South-South Nigeria: The Calabar Experience

Demographics and Overall Survival Pattern of Chronic Myeloid Leukemia in a Tertiary Hospital in South-South Nigeria: The Calabar Experience

Comparative study of hemostasis file in newly diagnosed leukemia patients and healthy persons at the Hematology and Blood Transfusion Department, National Hospital, Abuja

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