Demographic predictors of head and neck cancer survival differ in the elderly

Cass, Lauren M.; Challapalli, Sai D; Zahirsha, Zisansha; Simpson, M.C.; Ward, Greg

doi:10.1002/lary.27289

Cited by 19 publications

(13 citation statements)

References 49 publications

(112 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We also assessed the expression levels of the HPRT1 gene in patients with HNSCC with different sex, age, pathological stage and histological grades in TCGA–HNSCC and our validation cohorts. The sex‐based and age‐based differences have contributed to the clinical presentations and prognosis of patients with HNSCC, respectively [32–35]. The sex‐based analysis for both cohorts indicated the significant overexpression of HPRT1 gene level in tumor samples of both sexes compared with the normal tissues.…”

Section: Discussionmentioning

confidence: 99%

Overexpression of HPRT1 is associated with poor prognosis in head and neck squamous cell carcinoma

et al. 2021

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Overexpression of HPRT1 is associated with poor prognosis in head and neck squamous cell carcinoma

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In the context of oropharyngeal cancer, we conclude that the age at diagnosis for non-oropharyngeal HNC patients remains significantly older than for patients with oropharyngeal cancer. Age is an important factor in HNC treatment decisions and outcomes [24] and sociodemographic factors prognostic in survival differ among elderly versus nonelderly patients of HNC [25]. If the trend we observed over 40 years continues to hold, along with the projected aging of the both general and the cancer survivor population of the United States [26,27], the role of the patient's age and its associated physical and cognitive factors in HNC cancer care and therapeutic options might become even more important in the future [25].…”

Section: Discussionmentioning

confidence: 99%

Change in Age at Diagnosis of Oropharyngeal Cancer in the United States, 1975–2016

Cline

Simpson

Gropler

et al. 2020

Cancers

Self Cite

View full text Add to dashboard Cite

The emergence of the human papillomavirus (HPV) as the primary etiology of oropharyngeal cancer has changed head and neck cancer (HNC) epidemiology. This study described change in the age at diagnosis of oropharyngeal and non-oropharyngeal HNC in the United States in the last four decades. Using a retrospective cohort analysis, the Surveillance, Epidemiology, and End Results dataset from 1975 to 2016 was queried for eligible adult cases of HNC, grouped as oropharyngeal (n = 31,702) versus non-oropharyngeal (n = 87,108). Age at diagnosis was compared by gender (female, male) using independent t-test, and by race/ethnicity (Hispanic, non-Hispanic black, non-Hispanic white, non-Hispanic other) using analysis of variance. Joinpoint regression estimated yearly increases/decreases in age of diagnosis by sex and race/ethnicity through annual percent changes (APC), which were summarized with average annual percent changes (AAPC). Mean age at diagnosis for oropharyngeal cancer was 60.3 years. While there was initially a decrease in age at diagnosis, a 0.37% annual increase occurred from 2002 to 2016 (APC = 0.37, 95% confidence interval (CI) 0.28, 0.45). For non-oropharyngeal cancer, mean age at diagnosis was 63.2 years, with a continuous increase in age at diagnosis throughout the study period (1975–2016 AAPC = 0.08, 95% CI 0.04, 0.12). Females had higher average age at diagnosis than males for both sites, while blacks (57.4 years for oropharyngeal cancer; 59.0 years for non-oropharyngeal) had the lowest age at diagnosis of all races/ethnicity. Age at diagnosis of oropharyngeal cancer has increased significantly since 2002, while non-oropharyngeal HNC has increased significantly in the last four decades.

show abstract

“…Patients with improved survival are often HPV positive, of working age, and have only a few coexisting conditions, and for these patients reductions in treatment have been discussed [10, 11]. However, only a few authors have focussed on patients with the poorest prognosis–the older patients with coexisting conditions and high WHO scores [12, 13]. Treatment-induced side effects [14] [15] can be bearable as long as substantial duration of survival may be expected, but if it were possible to identify patients for whom it was short, resources could be more effectively spent on palliative, or at best supportive, care.…”

Section: Introductionmentioning

confidence: 99%

Early mortality after diagnosis of cancer of the head and neck – A population-based nationwide study

Talani¹,

Mäkitie²,

Beran³

et al. 2019

PLoS ONE

View full text Add to dashboard Cite

BackgroundCancers of the head and neck have a high mortality rate, and roughly 10% of the patients die within six months of diagnosis. To our knowledge little has been written about this group.We wished to identify risk factors for early death, to predict and monitor patients at risk better and, if possible, avoid unjustified major treatment.Methods and findingsThis population-based nationwide study from the Swedish Head and Neck Cancer Register (SweHNCR) included data from 2008–2015 and 9733 patients at potential risk of early death.A total of 925 (9.5%) patients died within six months. For every year older the patients became, the risk of early death increased by 2.3% (p<0.001). The relative risk of death was 3.37 times higher (237%) for patients with WHO score 1 compared with WHO score 0. A primary tumour in the hypopharynx correlated with a 24% increased risk over the oral cavity (p<0.024). Patients with stage IV disease had a 3.7 times greater risk of early death than those with stage I (p<0.001). As expected, a 12 times increased risk of early death was noted in the palliative treatment group, compared to the curative group.Limitations to this study were that the actual cause of death was not recorded in the SweHNCR, and that socioeconomic factors, alcohol consumption, smoking habits, and HPV status, were not reported in SweHNCR until 2015. However, the fact that this is a population-based nationwide study including 9733 patients compensates for some of these limitations.ConclusionsIdentification of patients at increased risk of early death shows that older patients with advanced disease, increased WHO score, primary tumour in the hypopharynx, and those given palliative treatment, are more likely than the others to die from head and neck cancer within six months of diagnosis.

show abstract

Demographic predictors of head and neck cancer survival differ in the elderly

Abstract: 2c Laryngoscope, 2017.

Cited by 19 publications

References 49 publications

Overexpression of HPRT1 is associated with poor prognosis in head and neck squamous cell carcinoma

Overexpression of HPRT1 is associated with poor prognosis in head and neck squamous cell carcinoma

Change in Age at Diagnosis of Oropharyngeal Cancer in the United States, 1975–2016

Early mortality after diagnosis of cancer of the head and neck – A population-based nationwide study

Contact Info

Product

Resources

About