Demographic profile, clinical characteristics and medical management patterns of Indian coronary artery disease patients: a nationwide urban-based, real-world, retrospective, observational electronic medical record study– report of baseline data

Khan, Mohammed Yunus; Pandit, Sucheta; Guha, Santanu; Jadhav, Uday; Rao, M. Srinivasa; Gaurav, Kumar; Mane, Amey; Dubey, Akhilesh; Bhagwatkar, Hitendra; Venkataswamy, Keshavamurthy; Shah, Snehal

doi:10.1080/14779072.2021.1941872

Cited by 2 publications

(3 citation statements)

References 13 publications

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“…A large percentage of CorLipid participants (44.2%) reported current use of tobacco products at enrollment. Baseline clinical and demographic characteristics of the study participants, briefly described in Tables 1 and 2, share significant similarities with relevant cohorts recently published [26][27][28].…”

Section: Baseline and Demographic Characteristicsmentioning

confidence: 74%

Correlation of Serum Acylcarnitines with Clinical Presentation and Severity of Coronary Artery Disease

et al. 2022

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Recent studies support that acylcarnitines exert a significant role in cardiovascular disease development and progression. The aim of this metabolomics-based study was to investigate the association of serum acylcarnitine levels with coronary artery disease (CAD) severity, as assessed via SYNTAX Score. Within the context of the prospective CorLipid trial (NCT04580173), the levels of 13 circulating acylcarnitines were accurately determined through a newly developed HILIC-MS/MS method in 958 patients undergoing coronary angiography in the AHEPA University Hospital of Thessaloniki, Greece. Patients presenting with acute coronary syndrome had significantly lower median acylcarnitine C8, C10, C16, C18:1 and C18:2 values, compared to patients with chronic coronary syndrome (p = 0.012, 0.007, 0.018, 0.011 and <0.001, respectively). Among CAD subgroups, median C5 levels were significantly decreased in unstable angina compared to STEMI (p = 0.026), while median C10, C16, C18:1 and C18:2 levels were higher in stable angina compared to STEMI (p = 0.019 p = 0.012, p = 0.013 and p < 0.001, respectively). Moreover, median C2, C3, C4 and C8 levels were significantly elevated in patients with diabetes mellitus (p < 0.001, <0.001, 0.029 and 0.011, respectively). Moreover, short-chain acylcarnitine C2, C4, C5 and C6 levels were elevated in patients with heavier calcification and lower left ventricular ejection fraction (LVEF) % (all p-values less than 0.05). With regard to CAD severity, median C4 and C5 levels were elevated and C16 and C18:2 levels were reduced in the high CAD complexity group with SYNTAX score > 22 (p = 0.002, 0.024, 0.044 and 0.012, respectively), indicating a potential prognostic capability of those metabolites and of the ratio C4/C18:2 for the prediction of CAD severity. In conclusion, serum acylcarnitines could serve as clinically useful biomarkers leading to a more individualized management of patients with CAD, once further clinically oriented metabolomics-based studies provide similar evidence.

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Section: Baseline and Demographic Characteristicsmentioning

confidence: 74%

Correlation of Serum Acylcarnitines with Clinical Presentation and Severity of Coronary Artery Disease

et al. 2022

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“…The significant differences in atherosclerosis progression risk related to urban and rural regions have already been narrated [ 10 , 11 ]. Not only air pollution components [ 12 ] but also noise exposure [ 13 ] and climate changes [ 14 ] are highlighted as causative features for cardiovascular morbidity.…”

Section: Introductionmentioning

confidence: 99%

“…The impact of the types and quality of development on occupants' condition has been reported [9], though there are substantial gaps in the evidence. The significant differences in atherosclerosis progression risk related to urban and rural regions have already been narrated [10,11]. Not only air pollution components [12] but also noise exposure [13] and climate changes [14] are highlighted as causative features for cardiovascular morbidity.…”

Section: Introductionmentioning

confidence: 99%

The Interplay between Dyslipidemia and Neighboring Developments in Coronary Artery Disease Progression: A Personalized Approach

Urbanowicz,

Skotak,

Olasińska-Wiśniewska

et al. 2024

JPM

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(1) Background: Estimates suggest that up to 10% of global annual cardiovascular deaths could be related to environmental factors. Not only air pollution components, but also noise exposure and climate changes, are highlighted as nontraditional causes of cardiovascular morbidity. The aim of this study was to identify possible urbanization risk factors for the progression of coronary artery disease in a group of patients with chronic coronary syndrome. (2) Method: There were 77 patients (50 (65%) males and 27 (35%) females) with a median age of 70 (60–74) years who underwent repetitive angiography due to chronic coronary syndrome between 2018 and 2022. The Gensini score was calculated for assessment of coronary artery disease advancement. Environmental factors including neighboring developments were taken into account in this analysis, including housing, commercial, and industrial developments within 300, 500, and 700 m distances (buffer) from the place of habitation. (3) Results: The multivariable analysis results for prediction of Gensini score progression in relation to 700 m buffer urbanization pointed out the significance of hyperlipidemia (OR: 4.24, 95% CI 1.34–13.39, p = 0.014), initial Gensini score (OR: 1.02, 95% CI 1.00–1.05, p = 0.112), and neighborhood housing (OR: 0.03, 95% CI 0.01–0.49, p = 0.025). (4) Conclusions: Hyperlipidemia and housing neighborhood can be regarded as possible factors for coronary disease progression in patients with chronic coronary syndrome with the use of optimal medical therapy.

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Demographic profile, clinical characteristics and medical management patterns of Indian coronary artery disease patients: a nationwide urban-based, real-world, retrospective, observational electronic medical record study– report of baseline data

Abstract: Demographic profile, clinical characteristics and medical management patterns of Indian coronary artery disease patients: a nationwide urban-based, real-world, retrospective, observational electronic medical record study -report of baseline data

Cited by 2 publications

References 13 publications

Correlation of Serum Acylcarnitines with Clinical Presentation and Severity of Coronary Artery Disease

Correlation of Serum Acylcarnitines with Clinical Presentation and Severity of Coronary Artery Disease

The Interplay between Dyslipidemia and Neighboring Developments in Coronary Artery Disease Progression: A Personalized Approach

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