Demographic profile of Acute Pancreatitis in Eastern India: A Single Centre Experience

Mukherjee, Dibyendu; Bhakta, Shantanu; Lahiry, Sandeep; Sinha, Rajasree

doi:10.3126/ajms.v8i6.18282

Cited by 10 publications

(13 citation statements)

References 16 publications

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“…In our study acute pancreatitis was more commonly seen in men associated with alcoholism, followed by gall stones in females, similar to a study conducted at IPGMER, Kolkata Eastern India from January 2014 to January 2017 in 234 patients. 26 Procalcitonin in our study was found to be high in patients of severe acute pancreatitis and the same observation were made at two different study done at Poland by Kolber et al 27 and at Finland by Back et al 28 receptively.…”

Section: R E S U L T Ssupporting

confidence: 88%

Evaluation of Procalcitonin as an Early Prognostic Marker in Acute Pancreatitis

Kaur¹,

Singh²

2020

jebmh

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BACKGROUND Acute Pancreatitis is usually a mild disease with minimal organ dysfunction. Sometime it can have severe complications and high mortality despite treatment. There is a need to identify patients at risk for complications so as to provide an early effective management. Procalcitonin, an inflammatory biomarker increases in acute pancreatitis with complications. So, we studied procalcitonin serum levels in acute pancreatitis patients to see if it can be used as an early predictor of development of complications. METHODS This was a prospective observational study, carried out at our tertiary care teaching hospital, north INDIA. A total of 60 cases were included in this study as per the inclusion criteria. Serum procalcitonin of ≥0.5 ng/ml was taken as significant. RESULTS Serum procalcitonin (PCT) was found to be non-significant in 61.6% (37 out of 60) patients, out of these, none had any complication, antibiotics use, low CT Severity Index (CTSI) score, early recovery and no death. Serum procalcitonin (PCT) was significant in 38.3% (23 out of 60) patients. CTSI score (>5) in 19 of these patients. Hypotension and respiratory failure were seen in 20 and 21 patients respectively with a significant p value of 0.001. Antibiotic use was observed in all the 23 patients in this group (p value 0.05). Duration of hospital stay was longer (more than mean 7.08±4.018 days) with significant p value of 0.005. Four participants died due to the complications related to acute severe pancreatitis. Mean value of PCT in participants who died was 4.2 ± 3.47 ng/ml with p value of 0.005 CONCLUSIONS Serum procalcitonin level in acute pancreatitis had good correlation with development of complications of cardiovascular, respiratory system, high CT score, and longer duration of hospital stay, antibiotic use and death. Hence procalcitonin can be used to predict complication at an early stage of acute pancreatitis.

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Section: R E S U L T Ssupporting

confidence: 88%

Evaluation of Procalcitonin as an Early Prognostic Marker in Acute Pancreatitis

Kaur¹,

Singh²

2020

jebmh

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“…[ 18 ] in their study found alcohol as major cause of pancreatitis in 59.35% of their patients. Mukherjee et al .,[ 23 ] in their study reported alcohol as a major etiology of AP in Eastern India. Macro[ 24 ] observed that the most common etiology was alcohol consumption (39.3%) followed by gallstones (24.1%).…”

Section: Discussionmentioning

confidence: 99%

Clinical Profile, Etiology, and Outcome of Acute Pancreatitis

Patel

Shyam

Atam

et al. 2022

Annals of African Medicine

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Background: Acute pancreatitis (AP) is an inflammatory process of the pancreas with varying degree of involvement of regional tissues. This was a population-based study on the incidence of AP. We aimed to determine the incidence, etiology, and outcome of AP. Materials and Methodology: This prospective study was conducted in the Department of Medicine, King George's Medical University, Lucknow, India, on 120 patients of AP. Clinical history, examination, and laboratory investigations were done. Severity of AP was assessed using the modified Atlanta classification. Results: A total of 120 patients comprising of 88 men (73.33%) and 32 women (26.66%) were recruited. The mean age of study participant was 36.96 ± 13.44 years. The most common presentation was abdominal pain followed by vomiting. The leading etiological factors were alcohol in 85 patients (70.8%) and gallstones in 25 (20.8%). It was idiopathic 5 patients (4.1%). Mortality was seen in three (2.5%) patients, all of which had severe pancreatitis. Patients with body mass index (BMI) ≥25 kg/m 2 , Hematocrit (HCT) ≥44% and C-reactive protein (CRP) ≥150 mg/l had an increased risk of developing a severe AP. Conclusions: Alcohol and gallstones were the most common etiological factors of AP, whereas HCT, CRP, and BMI were the useful predictors of severe pancreatitis.

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“…Alcohol was the commonest cause for acute pancreatitis in studies by 50% (n=54) by Chauhan et al,59.63% (n=123) by Negi et al, and 51% (n=110) by Vengadakrishnan et al [12][13][14]. In a study from Kolkata of 234 patients, AAP constituted only 29% [15]. Their study had 63.5% with diabetes mellitus and 56.2% smokers compared to 22.5% and 29.5% in our study respectively.…”

Section: Discussionmentioning

confidence: 99%

Electrocardiogram Heart Rate as a Predictor of Severity in Acute Alcohol-Related Pancreatitis With Alcohol Withdrawal Syndrome

Viswanathan

Jain

Gayathri

2020

Cureus

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Background The severity of acute alcohol-related pancreatitis (AAP) with alcohol withdrawal syndrome (AWS) has not been studied. Electrocardiogram (ECG) has not been used as a predictor of severity in patients with AWS and acute pancreatitis. Objectives The study aimed to determine whether the ECG heart rate (HR) could predict the severity of AAP; secondarily, whether AWS influenced the severity of AAP based on Acute Physiology and Chronic Health Evaluation (APACHE) II and Bedside Index for Severity in Acute Pancreatitis (BISAP). Methods Demographics, comorbid illnesses, AWS, biochemistry, ECG, arterial blood gases, and CT findings were noted in patients with AAP. The severity of pancreatitis was scored into mild, moderate, and severe based on CT. BISAP, APACHE II, and ECG heart rate-APACHE (E-APACHE) were compared in patients with and without AWS. A receiver operating characteristic curve was used to find the best predictor of severity. Results Among 138 patients (M=128), 94 had AWS. ECG changes (≥1) were seen in 50%. Patients with AWS were younger, had consumed alcohol for a shorter duration, had higher systemic inflammatory response syndrome (SIRS), APACHE II, and E-APACHE II scores. APACHE II and E-APACHE II correlated significantly with severity grading, HR, alcohol duration, and AWS. HR was the best predictor of severe pancreatitis; E-APACHE was the best predictor for moderately severe pancreatitis. Conclusions Mostly, AAP appears to be mild; >2/3 rds have AWS. ECG findings were seen in 50%. HR has not been previously studied in patients with both AAP and AWS and is an easy and inexpensive test to predict the severity of pancreatitis in this cohort.

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Demographic profile of Acute Pancreatitis in Eastern India: A Single Centre Experience

Cited by 10 publications

References 16 publications

Evaluation of Procalcitonin as an Early Prognostic Marker in Acute Pancreatitis

Evaluation of Procalcitonin as an Early Prognostic Marker in Acute Pancreatitis

Clinical Profile, Etiology, and Outcome of Acute Pancreatitis

Electrocardiogram Heart Rate as a Predictor of Severity in Acute Alcohol-Related Pancreatitis With Alcohol Withdrawal Syndrome

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