Demographic proles of epileptic patients and their awareness towards epilepsy with the inuence on compliance

Mian, Ferdous; Jobayer, Mohammad; Afroz, Zeenat; Chowdhury, Ahmed Hossain; Chowdhury, Rajib Nayan; Habib, Mansur; Mohammad, Quazi Deen

doi:10.3329/bmj.v45i1.28961

Cited by 4 publications

(4 citation statements)

References 11 publications

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“…In this current study it was observed that male were predominant among the epilepsy patients which was 62.7% of the study population. This male predominance was also observed in studies 20,22 .…”

Section: Discussionsupporting

confidence: 82%

Association of Insulin Resistance with Sodium Valproate Therapy among Epileptic Patient

Haque

Islam

Alam

et al. 2017

Bangla. J. Neuroscience

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Background: Epilepsy is a common neurological disorder. Sodium valproate is one of the commonest broad spectrum antiepileptic drugs and it is used worldwide. Weight gain is the common side effect which is known to be associated with insulin resistance. The aim of this study was to see the association of sodium valproate therapy with insulin resistance among epileptic patients. Methods: It was a cross-sectional analytical study. Total 102 patients (51 epileptic patients with valproate monotherapy for at least one year and another 51 age and sex matched newly diagnosed epileptic patients without any anti-epileptic drugs) were selected in this study. The study was carried out from March 2016 to April 2017 for one year in the epilepsy clinic and outpatient Department of Neurology at Bangabandhu Sheikh Mujib Medical University, Dhaka. Participants underwent anthropometric evaluations and biochemical tests including fasting blood sugar and fasting insulin level. Insulin resistance (IR) index was calculated. Result: In this study mean duration of valproate treatment was 3.12±1.26 years and mean sodium valproate dose was 1133±440.5 mg/day (17.7±6.65 mg/kg/day). This study revealed serum fasting insulin level in valproate group and non-valproate group was 11.05±4.86 (ìU/ml) and 7.39±2.01 (ìU/ml) respectively. Fasting blood glucose was 4.71±0.79 (mmol/L) in valproate group and 4.41±0.62 (mmol/L) in non- valproate group. Calculated IR index in valproate group and non-valproate group was 2.17±0.55 and 1.46±0.39 respectively. IR index, fasting insulin and blood glucose all were significantly higher in valproate group than non- valproate group. This study also revealed mild positive correlation of IR index with dose and duration of valproate treatment. Conclusion: Sodium valproate treated patient had significantly higher IR index than control group. Bangladesh Journal of Neuroscience 2017; Vol. 33 (2): 63-69

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Section: Discussionsupporting

confidence: 82%

Association of Insulin Resistance with Sodium Valproate Therapy among Epileptic Patient

Haque

Islam

Alam

et al. 2017

Bangla. J. Neuroscience

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“…The incidence of epilepsy is high in childhood which decreases in adulthood and can rise again in older age. The first peak occurs in the childhood as well as the young adults; however, another peak age is in old age" [5]. "Epilepsy cases are reported higher in rural area than in urban area especially in developing countries" [6].…”

Section: Introductionmentioning

confidence: 99%

Bone Mineral Density in Epileptic Children Getting Long Term Anti-epileptic Drugs

Kabir,

Bodruddoza,

After

2023

AJPR

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Background: Epilepsy is a common chronic neurological disorder with more than half of cases beginning in childhood. Most patients require long-term, and sometimes life-long, therapy with antiepileptic drugs (AEDs). AEDs are associated with significant side effects including radiological evidence of rickets, decreased bone mineral density (BMD), altered bone turnover, and increased risk of fracture. Aim of the Study: To assess the bone mineral density in epileptic children getting long term anti-epileptic drugs. Materials and Methods: This study was conducted in the Saleh Child Development and Disability Management Center (SCDDMC), of the Institute of Child and Mother Health (ICMH) Matuail, Dhaka. A total of 31 childrens age ranged 5-15 years diagnosed as epilepsy on the basis of both clinical examination and investigation (EEG) receiving antiepileptic drugs (AEDS) for at least two years were recruited in this study. Results: Almost two third (61.3%) children age group were in 5 to 10 years and 12(38.7%) in 10 to 15 years. Around three fourth (74.2%) children were male and 8(25.8%) were female. More than two third (67.7%) children had adequate sun exposure and more than three fourth (77.4%) children got adequate calcium and vit.D rich food. Majority (83.9%) of the patients got phenobarbitone (PB) followed by 17(54.8%) got combination, 13(41.9%) got valproic acid (VPA), 11(35.5%) got Nitrazipum (NTZ). More than one third (38.7%) children got mono therapy, 19(61.3%) got polytherapy. Majority of the children (96.8%) had serum calcium normal. The mean serum calcium was 9.22±0.78 mg/dl. The mean BMD of spine was 0.66±0.14. The mean BMD of neck left femur was 0.66±0.15. The mean BMD of neck right femur 0.66±0.15. More than two third (67.7%) children had low (<-1SD) BMD Z score. Almost two third (60.0%) children had mono therapy showed BMD Z score normal (>-1SD) and 6(28.6%) had BMD Z score low (<-1SD). Almost three fourth (71.4%) children got poly therapy showed low BMD and 4(20.0%) got poly therapy showed normal BMD Z score. No significant association was found between BMD score and type and duration of therapy. Conclusion: AEDs decreased bone mineral density due to long term use as mono-therapy or polytherapy. The assessment of BMD among children with epilepsy receiving long term AEDs is essential.

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“…2023 seizure for more than six months and uncontrolled when one or more seizures over a period of six months during treatment of epilepsy 4 . The effects of antiepileptic drug carbamazepine may be due to induction of cytochrome P450 (CYP) enzymes in the liver.…”

mentioning

confidence: 99%

Effects of Carbamazepine and Sodium Valproate on Serum Cholesterol in Epileptic Patients

Mosharraf Hossain,

Sultana,

Rahman

et al. 2023

Med. Today

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Introduction: Epilepsy is a common, chronic and non-communicable disorder of the brain. Carbamazepine, increasing serum cholesterol level, causes adverse cardiovascular and cerebrovascular events. Sodium valproate causes weight gain, hyperinsulinemia and insulin resistance leading to metabolic syndrome. These all causes increased morbidity and mortality of epileptic patients in later life. Objective: to find out the effects of carbamazepine and sodium valproate on serum cholesterol in epileptic patients. Materials and Methods: This cross-sectional study was conducted in the Department of Biochemistry, Dhaka Medical College during the period of July 2017 to June 2018. A total of sixty diagnosed epileptic patients were selected, of them, thirty patients were taking carbamazepine and thirty on sodium valproate. Data were analyzed with the help of SPSS version 22.0. Unpaired Student’s t-test and Mann-Whitney U test were done to see the level of significance (p<0.05). For correlation, Pearson’s correlation coefficient test was done. Result: Mean ± SD of serum total cholesterol in carbamazepine and sodium valproate patients were 218.73 ± 29.70 mg/dl and 190.14 ± 17.10 mg/dl respectively (p<0.001). Conclusion: This study reveals that hypercholesterolemia is related to carbamazepine medications. Medicine Today 2023 Vol.35(2): 83-86

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Demographic proles of epileptic patients and their awareness towards epilepsy with the inuence on compliance

Cited by 4 publications

References 11 publications

Association of Insulin Resistance with Sodium Valproate Therapy among Epileptic Patient

Association of Insulin Resistance with Sodium Valproate Therapy among Epileptic Patient

Bone Mineral Density in Epileptic Children Getting Long Term Anti-epileptic Drugs

Effects of Carbamazepine and Sodium Valproate on Serum Cholesterol in Epileptic Patients

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