Demographics and Clinical Characteristics of Multiple Sclerosis in Kuwait

Alroughani, Raed; Ahmed, Samar Farouk; Al-Hashel, Jasem

doi:10.1159/000362270

Cited by 14 publications

(14 citation statements)

References 11 publications

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“…The percentage of MS patients with family history is comparable to figures in the region as well as figures in the west (13.32% in Kuwait, 15-20% in regions such as Europe, Canada, and North America). 19,21 Compared to a previous study conducted in Saudi Arabia in 2010, where 21% of the MS patients reported familial history, 6 our data showed only 12.8% of patients reported any familial history. This suggests that the increasing prevalence of MS in Saudi Arabia is not related to the familial history.…”

Section: Resultscontrasting

confidence: 79%

“…Looking at the demographic findings, we observed that the female to male ratio was about 2:1.This female predominance is consistent with other universal well-established registries. 18 – 20 The overall percentage of MS patients with family history was 12.8% of which 6.3% had at least one sibling affected. The percentage of MS patients with family history is comparable to figures in the region as well as figures in the west (13.32% in Kuwait, 15–20% in regions such as Europe, Canada, and North America).…”

Section: Discussionmentioning

confidence: 99%

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Familial aggregation of multiple sclerosis: Results from the national registry of the disease in Saudi Arabia

Aljumah

Otaibi²,

Towaijri

et al. 2020

Multiple Sclerosis Journal - Experimental, Translational and Cl

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Background Multiple Sclerosis (MS) is a chronic CNS inflammatory disease commonly affecting young adults. Both genetics and environmental factors have been reported to have a role in pathophysiology of the disease. Objective This article aims to report familial nature and aspects of MS in Saudi Arabia. Method The study utilized data collected by the National Saudi MS Registry between 2015 and 2018; especially data relevant to the familial history of MS. SPSS 22 was used for all analysis and reporting. Statistical significance was set at p-value < 0.05. Results The registry included 20 hospitals and a total of 2516 patients from the different regions of Saudi Arabia with median age 32.00 (Range: 11–63) and 66.5% being female. About 12.8% of all registered patients reported a family history of MS (95%CI: 11.2-13.9). Reported parental consanguinity was significantly higher among patients with family history (FMS) (56.3%) compared to non-FMS patients (27.9%). 42.53% of FMS patients reported having siblings affected with MS (95%CI: 37.01–48.21), with more female siblings affected than males (63.4% vs 36.6% respectively). Conclusion Our Findings suggested that FMS was less prevalent than what was reported previously; however, parental consanguinity was significantly more prevalent among FMS patients than non-FMS. Our findings were in line with those reported in recent studies in the region, but lower than those reported by western countries indicating that increasing prevalence of MS in Saudi Arabia could be multifactorial and other environmental factors should be considered for understanding this recent rise in the prevalence of MS in Saudi Arabia.

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Section: Resultscontrasting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Familial aggregation of multiple sclerosis: Results from the national registry of the disease in Saudi Arabia

Aljumah

Otaibi²,

Towaijri

et al. 2020

Multiple Sclerosis Journal - Experimental, Translational and Cl

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“…These findings need to be reconsidered since PRMS has been eliminated and categorized as PPMS with activity and CIS is now considered part of the spectrum of MS after the 2013 revisions by the international advisory committee on clinical trials of MS. 8 The clinical phenotype findings in our study were very similar to those found in recent studies from the United Arab Emirates and Kuwait. 31 32 …”

Section: Discussionmentioning

confidence: 99%

Clinical Presentations and Phenotypic Spectrum of Multiple Sclerosis at a University Hospital in Saudi Arabia

et al. 2018

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Background and PurposeThe objective of this study was to determine the frequencies of different clinical presentations and the phenotypic spectrum of multiple sclerosis (MS).MethodsThis cross-sectional study was performed in the Neurology Department of King Fahd Hospital of University Alkhobar in the Kingdom of Saudi Arabia (KSA). Data of 190 MS patients who fulfilled the McDonald criteria were retrieved from medical records and analyzed.ResultsThe age at disease onset was 26.27±8.2 years (mean±SD) and disease duration was 6.38±5.10 years. The male-to-female ratio was 1:1.6. Optic neuritis and myelitis were the most-frequent first clinical presentations. Sensory (73.1%), motor (61%), and visual (58.4%) symptoms were the most-frequent established clinical symptoms. Relapsing-remitting multiple sclerosis (RRMS) was present in 75% of the cases. Supratentorial T2-weighted white-matter lesions and deep-gray-matter or juxtacortical lesions were the most-frequent magnetic resonance imaging (MRI) lesions, comprising 28% and 23.7% of all MRI lesions observed in 93.6% and 79.4% of the cases, respectively. The scores on the Expanded Disability Status Scale were within the range of 1.0–5.5 in 82.1% of the patients. There were 145 (76.3%) patients taking interferon β therapy.ConclusionsMS presenting in the hospital setting is more common in KSA than reported previously, and the number of diagnosed cases in increasing. It is therefore an emerging and disabling neurological illness in KSA with clinical characteristics not dissimilar to those in other middle eastern countries. A decrease in the frequency of patients with secondary progressive multiple sclerosis (SPMS) indicates either that more new cases of RRMS are being diagnosed or that adequate treatments of RRMS are preventing the evolution to SPMS. Further larger and population-wide epidemiological and clinical studies with the long-term follow-up of MS patients are required to better assess the clinical spectrum of MS in KSA.

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“…3,4 The registry was established in 2010 after combining the databases of all major hospitals including MS clinics, which together accounted for nearly 98% of the MS patients diagnosed in the country. MS patients' data were retrieved from patient records and were screened for accuracy before entering them in the registry.…”

Section: Methodsmentioning

confidence: 99%

Pediatric-Onset Multiple Sclerosis Disease Progression in Kuwait: A Retrospective Analysis

Alroughani

Ahmed

Al-Hashel

2015

Pediatric Neurology

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Demographics and Clinical Characteristics of Multiple Sclerosis in Kuwait

Cited by 14 publications

References 11 publications

Familial aggregation of multiple sclerosis: Results from the national registry of the disease in Saudi Arabia

Familial aggregation of multiple sclerosis: Results from the national registry of the disease in Saudi Arabia

Clinical Presentations and Phenotypic Spectrum of Multiple Sclerosis at a University Hospital in Saudi Arabia

Pediatric-Onset Multiple Sclerosis Disease Progression in Kuwait: A Retrospective Analysis

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