Demographics and outcomes of microcystic adnexal carcinoma

King, Brian J.; Tolkachjov, Stanislav N.; Winchester, Daniel S.; Baum, Christian L.; Brewer, Jerry D.; Arpey, Christopher J.; Otley, Clark C.; Roenigk, Randall K.

doi:10.1016/j.jaad.2018.03.010

Cited by 27 publications

(35 citation statements)

References 4 publications

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“…1 The tumours present as slowly growing, poorly defined plaques with a predilection for the central face, especially the periorbital area, the nasolabial folds, cheeks, and chin. [1][2][3][4][5] Although the age range is wide, adults are typically affected without significant sex bias. [1][2][3][4][5] The tumours are of low-grade malignant potential with a risk for local recurrence and locally destructive growth.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5] Although the age range is wide, adults are typically affected without significant sex bias. [1][2][3][4][5] The tumours are of low-grade malignant potential with a risk for local recurrence and locally destructive growth. Rare cases resulting in lymph node metastasis have been reported, but distant metastasis and disease-related mortality are exceptional.…”

Section: Introductionmentioning

confidence: 99%

“…Rare cases resulting in lymph node metastasis have been reported, but distant metastasis and disease-related mortality are exceptional. 3,4,6 Morphologically, the tumours are characterised by diffusely infiltrative growth within the dermis and frequent invasion of underlying subcutaneous adipose tissue, skeletal muscle, and fascia. They are composed of solid epithelial nests and strands in a desmoplastic stroma with focal lumen or duct formation.…”

Section: Introductionmentioning

confidence: 99%

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Morphologically high‐grade microcystic adnexal carcinoma: a report of two cases

2020

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Aims Microcystic adnexal carcinoma is a distinctive sweat duct carcinoma of low‐grade malignant potential with a risk for locally destructive growth and local recurrence. Distant metastases and disease‐related mortality are exceptional. The histological hallmarks of these tumours are the diffusely infiltrative growth within the dermis, the frequent invasion of subcutaneous structures, the presence of perineurial invasion, and the bland cytological features. The tumours are organised in cords and strands, and show keratocyst formation and duct differentiation in varying proportions. Marked cytological atypia, nuclear pleomorphism, brisk and atypical mitotic activity and necrosis are not typically seen in these tumours. Methods and results We report two patients presenting with large, slowly growing tumours on the face showing areas of morphologically high‐grade carcinoma arising on a background of unequivocal microcystic adnexal carcinoma. Both patients are alive with follow‐up of up to 6 years, with no evidence of disease. Conclusions Morphologically high‐grade transformation in microcytic adnexal carcinoma is a rare phenomenon that does not appear to confer a risk for aggressive behaviour. Recognition depends on sampling of the areas of conventional microcystic adnexal carcinoma.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Morphologically high‐grade microcystic adnexal carcinoma: a report of two cases

2020

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“…Microcystic adnexal carcinoma (MAC) is a rare, indolent, low-grade, malignant cutaneous neoplasm believed to arise from the sweat glands most commonly seen in the head and neck area. 1,2 Since MAC was first described as a distinct histologic entity in 1982, 3 less than 700 cases have been reported worldwide. MAC typically affects middle aged to elderly whites.…”

Section: Introductionmentioning

confidence: 99%

“…MAC lesions usually present as a solitary, slow-growing 1-to 3-cm white yellowish papule or plaque located primarily over the face. 1,[4][5][6] Patients are generally asymptomatic and may present years after initial development of the skin lesion. 7,8 Some develop ulceration or paresthesia if there is perineural invasion (PNI).…”

Section: Introductionmentioning

confidence: 99%