Demographics and Outcomes of Patients With Pediatric Febrile Convulsive Status Epilepticus

Nishiyama, Masahiro; Nagase, Hiroaki; Tanaka, Tsukasa; Fujita, Kyoko; Maruyama, Azusa; Toyoshima, Daisaku; Nagao, Taku; Taniguchi‐Ikeda, Mariko; Morioka, Ichiro; Morisada, Naoya; Takada, Satoshi; Iijima, Kazumoto

doi:10.1016/j.pediatrneurol.2015.02.001

Cited by 19 publications

(19 citation statements)

References 27 publications

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“…Aetiology is the major determinant of outcome . However, even children with no apparent pre‐existing neurological problems at CSE show evidence of short‐term structural and functional consequences after CSE …”

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confidence: 99%

Long‐term behavioural outcomes after paediatric convulsive status epilepticus: a population‐based cohort study

Martinos

Pujar

Gillberg

et al. 2017

Develop Med Child Neuro

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AimTo describe behavioural and psychiatric outcomes of children within 10 years of convulsive status epilepticus (CSE).MethodChildren originally identified by the population‐based North London Convulsive Status Epilepticus in Childhood Surveillance Study were followed‐up between July 2009 and February 2013. They were grouped into epilepsy‐ and non‐epilepsy‐related CSE, and compared with population norms and healthy controls using the Strengths and Difficulties Questionnaire; the Autism Spectrum Screening Questionnaire; and the Swanson, Nolan, and Pelham questionnaire. Children who scored above recommended clinical cut‐offs on any scale were invited for a neuropsychiatric assessment. Regression models were fitted to identify clinically relevant covariates associated with behavioural outcomes.ResultsAt a mean follow‐up of 8.1 years post‐CSE, 28% of enrolled children were found to have a psychiatric disorder. Children with epilepsy‐related CSE scored higher than norms on all scales and children with non‐epilepsy‐related CSE scored higher than norms on the Strengths and Difficulties Questionnaire and the Autism Spectrum Screening Questionnaire. Presence of seizures at baseline and recurrence of CSE was associated with worse outcomes in the group with epilepsy. Intellectual abilities were associated with behavioural outcomes in all participants.InterpretationA large proportion of children manifest behavioural issues 8 years after CSE. The present data highlight the need for behavioural screening in children with neurodevelopmental impairments post‐CSE.What this paper adds Eight years post convulsive status epilepticus (CSE), 37% of parents report behavioural issues.Of enrolled children, 28% were found to have a Diagnostic and Statistical Manual mental disorder.Intellectual abilities are strongly associated with behavioural outcomes in children post‐CSE.

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confidence: 99%

Long‐term behavioural outcomes after paediatric convulsive status epilepticus: a population‐based cohort study

Martinos

Pujar

Gillberg

et al. 2017

Develop Med Child Neuro

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“…Although no medications or therapeutic procedures have been strictly proven to reduce the sequelae of acute encephalopathy, barbiturates and steroids uses are increased during the periods. These may be the results of several recent literature implicating the importance of early aggressive therapies to febrile status epilepticus [16,31,32].…”

Section: Discussionmentioning

confidence: 94%

Recent treatment patterns and variations for pediatric acute encephalopathy in Japan

Hayakawa

Okubo

Nariai

et al. 2020

Brain and Development

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“…The patient populations and/or pathologies evaluated in the 66 studies included in the final review were: general PICU patients (n=15 studies) (9–23), seizures and/or status epilepticus (SE) (n=7) (24–30), traumatic brain injury (TBI) (n=17) (31–47), cardiac arrest (n=22) (48–69), and infectious diseases (n=5) (70–74). …”

Section: Resultsmentioning

confidence: 99%

“…Among children with neurocritical illness, outcomes tend to be worse in children with stroke, cardiac arrest, and SE, compared to TBI (24,27,28). …”

Section: Neurologic Outcomes Following Picu Carementioning

confidence: 99%

Neurologic Outcomes Following Care in the Pediatric Intensive Care Unit

Caprarola

Kudchadkar

Bembea

2017

Curr Treat Options Peds

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Purpose of review With increasing survival of children requiring admission to pediatric intensive care units (PICU), neurodevelopmental outcomes of these patients are an area of increased attention. Our goal was to systematically review recently published literature on neurologic outcomes of PICU patients. Recent Findings Decline in neurofunctional status occurs in 3%–20% of children requiring PICU care. This proportion varies based on primary diagnosis and severity of illness, with children admitted for primary neurologic diagnosis, children who suffer cardiac arrest or who require invasive interventions during the PICU admission, having worse outcomes. Recent research focuses on early identification and treatment of modifiable risk factors for unfavorable outcomes, and on long-term follow-up that moves beyond global cognitive outcomes and is increasingly including tests assessing multidimensional aspects of neurodevelopment. Summary The pediatric critical care research community has shifted focus from survival to survival with favorable neurologic outcomes of children admitted to the PICU.

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Demographics and Outcomes of Patients With Pediatric Febrile Convulsive Status Epilepticus

Cited by 19 publications

References 27 publications

Long‐term behavioural outcomes after paediatric convulsive status epilepticus: a population‐based cohort study

Long‐term behavioural outcomes after paediatric convulsive status epilepticus: a population‐based cohort study

Recent treatment patterns and variations for pediatric acute encephalopathy in Japan

Neurologic Outcomes Following Care in the Pediatric Intensive Care Unit

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