This paper is based on the findings of a study carried out on the determinants of sexual functionality among men who utilize sex enhancing drugs (SEDs). The study was submitted as a thesis in partial fulfillment for the award of a degree of Master of Public Health Maseno University in the year 2019. The research design was cross sectional. Data for this study was collected using socio-demographic and International Index for Erectile Function (IIEF) questionnaires from a sample of 67 men above the age of 18 who were sampled purposively. The results from descriptive analysis indicated that 55% of the study participants are aged between 30 and 49 years, 64% are educated to secondary school and above, 68% have an occupation, 71% are non-smokers, 40% ride a bicycle, 91% are physically active and 30% have co-morbidity. On sexual functionality, 95% have some level of erectile dysfunction, at 85% a similar number have varying levels of orgasmic dysfunction and sexual desire. 98% have some level of intercourse dysfunction. The study demonstrate that the determinants of sexual functionality include age, marital status, education, alcohol consumption, bicycle riding, physical activity and co-morbidity. The study identifies socio-demographic factors, lifestyle and co-morbidity as risk factors to sexual functionality. It recommends that sexual functionality be given deserving public health attention.