Demography and disease characteristics of prostate cancer in India

Krishnamoorthy, H; Padmanabha, Venugopal

doi:10.4103/0970-1591.174774

Cited by 76 publications

(24 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prostate cancer is the most common forms of malignancy in men, particularly in developed countries where the majority of cases are diagnosed in men aged above 50 years. 1 Present treatments options available for prostate cancer includes surgical treatment, hormone therapy, radiation therapy, and chemotherapy; these treatments have shown improvement in patients but generally ends up with adverse and toxic side effects. 2 There has also been a wide use of dietary supplements such as vitamin E, selenium, soy products, lycopene, and green tea catechin in the treatment of prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

In vitro antioxidant and anticancer activity of Leea indica leaf extracts on human prostate cancer cell lines

Ghagane

Puranik

Kumbar

et al. 2017

Integrative Medicine Research

View full text Add to dashboard Cite

BackgroundTo determine the phytochemical constituents, antioxidant, and anticancer activities of Leea indica leaf extracts on DU-145 and PC-3 human prostate cancer cell lines.MethodsLeaf sample was subjected to Soxhlet extraction method with increasing polarity of solvents, namely, chloroform, ethyl acetate, methanol, ethanol, and aqueous. Phytochemical screening was done using different biochemical tests. Quantitative analysis for phenol was determined by Folin–Ciocalteu reagent method. The antioxidant activity was tested using 2,2-diphenyl-1-picrylhydrazyl, ferric ion reducing power assay, and phosphomolybdenum assay. In vitro anticancer activity on DU-145 and PC-3 human prostate cancer cell lines was evaluated by (3-(4, 5-dimethyl thiazole-2yl)-2, 5-diphenyl tetrazolium bromide) MTT assay.ResultsPhytochemical screening confirmed the presence of phyto-constituents like alkaloids, flavonoids, glycosides, phenols, lignins, saponins, sterols, tannins, anthraquinone, and reducing sugar. Methanol and ethanol extracts exhibited higher phenolic content as compare to aqueous extract. Antioxidant capacities were shown highest in methanol and ethanol extracts based on the test performed. The methanol and ethanol leaf extracts were found to be selectively cytotoxic in vitro to (DU-145 and PC-3) prostate cancer cell lines with IC50 values 529.44 ± 42.07 μg/mL and 677.11 ± 37.01 μg/mL for DU-145 and 547.55 ± 33.52 μg/mL and 631.99 ± 50.24 μg/mL for PC-3 respectively, while it had no cytotoxic effect on normal mice embryo fibroblast cells.ConclusionThe results indicate that Leea indica was a promising antioxidant and anticancer agent for DU-145 and PC-3 human prostate cancer cell lines. However, further studies are needed to conclude its therapeutic use.

show abstract

Section: Introductionmentioning

confidence: 99%

In vitro antioxidant and anticancer activity of Leea indica leaf extracts on human prostate cancer cell lines

Ghagane

Puranik

Kumbar

et al. 2017

Integrative Medicine Research

View full text Add to dashboard Cite

show abstract

“…1 The overall age-adjusted prostate cancer incidence rates in India was 3.7/100,000 persons during the year 2008 with regional variation of 0.8 in the state of Manipur and 10.9/100,000 person-years in Delhi. 2 3 These types of variation also exist in western countries with African American men having a high mortality rate of 43 per 100,000 in the period 2008 to 2011. 3 4 5…”

Section: Introductionmentioning

confidence: 99%

Prostate-Specific Antigen Density: A Measurement to Differentiate Benign Hypertrophy of Prostate from Prostate Carcinoma

et al. 2020

View full text Add to dashboard Cite

Background Determination of isolated prostate-specific antigen (PSA) in asymptomatic individuals has not demonstrated sufficient sensitivity and specificity to be useful in the routine evaluation of prostate disease. To enhance the accuracy of serum PSA we have used a proportion of serum PSA and prostate volume, which we refer to as prostate-specific antigen density (PSAD). Prostate volume in this study was calculated using transrectal ultrasonography (TRUS). Materials and Methods A total of 106 patients with prostatic disease clinically confined to the prostate glands were evaluated. Results and Observation The mean PSAD for prostate cancer was 0.15 ± 0.01 while that for benign hypertrophy of the prostate (BPH) was 0.11 ± 0.02 (p < 0.05). Significant difference (p < 0.05) was noted in the prostate volume in these two groups with the mean prostate volume measured by TRUS in the BPH to be 53.85 ± 9.71 mL compared with 58.14 ± 7.48 mL in the carcinoma. PSA density of 0.13 ng/mL can be used as a cutoff for the individual in our set-up who should go for prostate biopsy with sensitivity and specificity of over 90%. Conclusion These results suggest that PSAD may be useful in distinguishing BPH and prostate cancer.

show abstract

“…Prostate cancer is primarily a disease of the elderly with majority of patients presenting with age above 65 years. [ 1 ] It is the most common cancer in men worldwide and fifth most common cancer overall. Most metastatic prostate cancer patients present with high serum prostate-specific antigen (PSA) levels and often metastases occur at sites such as pelvic lymph nodes (LNs), bones, lungs, and liver in advanced cases.…”

Section: Introductionmentioning

confidence: 99%

Metastatic Thyroid Cartilage Lesion from Prostatic Adenocarcinoma on 68Ga-Prostate-Specific Membrane Antigen Positron Emission Tomography-Computed Tomography Scan

Gupta

Verma

Belho

2021

Indian Journal of Nuclear Medicine

View full text Add to dashboard Cite

Prostate cancer usually metastasizes to regional lymph nodes and bone. Laryngeal cartilage metastases are very rare and only few cases have been published so far describing thyroid cartilage metastatic lesions from prostate cancer. Here, we describe 5 cases of carcinoma prostate, 3 staging and 2 follow-up, where 68 Ga-prostate-specific membrane antigen positron emission tomography/computed tomography (PET/CT) scan revealed multiple skeletal lesions along with thyroid cartilage metastasis. Initially, laryngeal cartilage metastases remain asymptomatic and in later stages patients present with symptoms. These metastatic lesions to thyroid cartilage are rare entities and can often easily be missed on conventional imaging. PET-CT imaging has overcome this diagnostic problem due to its ability to provide for both anatomical and functional imaging.

show abstract

Demography and disease characteristics of prostate cancer in India

Cited by 76 publications

References 37 publications

In vitro antioxidant and anticancer activity of Leea indica leaf extracts on human prostate cancer cell lines

In vitro antioxidant and anticancer activity of Leea indica leaf extracts on human prostate cancer cell lines

Prostate-Specific Antigen Density: A Measurement to Differentiate Benign Hypertrophy of Prostate from Prostate Carcinoma

Metastatic Thyroid Cartilage Lesion from Prostatic Adenocarcinoma on 68Ga-Prostate-Specific Membrane Antigen Positron Emission Tomography-Computed Tomography Scan

Contact Info

Product

Resources

About