This article provides an overview of Sri Aurobindo's Integral Yoga Psychology (IYP), with a focus on relevance to clinical practice. After summarizing recent developments in integrative medicine that have brought transpersonal themes into the mainstream of contemporary healthcare, the transformational paradigm of IYP is used to articulate a spiritually-informed approach to psychology and psychiatry. Topics covered include the soul (psychic being), reincarnation, the chakra system, psychodynamic therapy, ego defenses, positive psychology, CBT, AA, parapsychology, and mind-body medicine. The possession model of illness is addressed in detail, using both case material and the author's own experience, and is compared to Jung's method of working with the shadow. Finally, a range of realworld issues are discussed, including cross-cultural considerations, the structure of healthcare systems, the stigma of mental illness, and psychopharmacology.