Demonstration and characterization of HLA-DR positive cells in the stroma of human endometrium

Laguens, Graciela; Goñi, JoséM.; Laguens, M; Laguens, Rubén M.

doi:10.1016/0165-0378(90)90015-x

Cited by 16 publications

(5 citation statements)

References 6 publications

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“…Furthermore, the presence of stromal lymphoid aggregates, containing cells expressing Langerin, CCR5, CD4, CD11c and CD68 could hypothetically constitute a site for HIV replication as well as a functional site for local immune responses. Although such aggregates have previously been described in endometrial [4], [16], [17], [18], [19] and ectocervical tissue [20], but not in other parts of the human female genital tract under non-inflammatory conditions, the presence of potential HIV receptors such as Langerin have not. Previous findings of CCR5 expression in human endometrium [21] and uterine epithelial cells [22] have now been extended with phenotypic characterization in both the intraepithelial and stromal compartment.…”

Section: Discussionmentioning

confidence: 99%

Detection of Intraepithelial and Stromal Langerin and CCR5 Positive Cells in the Human Endometrium: Potential Targets for HIV Infection

et al. 2011

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Both the upper (endocervix and uterus) and lower (ectocervix and vagina) female genital tract mucosa are considered to be target sites for sexual transmission of HIV. There are a few reports on the T cell and antigen-presenting cell distribution in human endometrial tissue however, there is little known about the expression of the HIV co-receptor CCR5 and HIV-binding C-type lectin receptors on endometrial cell subsets. We therefore assessed endometrial tissue sections from HIV seronegative women undergoing hysterectomy of a benign and non-inflammatory cause for phenotypic characterization of potential HIV target cells and receptors by immunohistochemistry. Langerin was expressed on intraepithelial CD1a+CD4+ and CD11c+CD4+ Langerhans cells. Furthermore, CCR5+CD4+CD3+ T cells, DC-SIGN+MR+CD11c+ myeloid dendritic cells and MR+CD68+ macrophages were found within or adjacent to the epithelium of the uterine lumen. In addition, occasional CD123+ BDCA-2+ plasmacytoid dendritic cells were detected deep in the endometrial stroma. Both T cells and several antigen-presenting cells were detected in lymphoid aggregate formations in close proximity to the epithelial lining. The finding of intraepithelial and stromal Langerin+ cells as well as CCR5+ CD4+ T cells is novel for human endometrium.

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Section: Discussionmentioning

confidence: 99%

Detection of Intraepithelial and Stromal Langerin and CCR5 Positive Cells in the Human Endometrium: Potential Targets for HIV Infection

et al. 2011

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“…The human reproductive tract contains a full spectrum of leukocytes with the potential to function in ways similar to those present at other mucosal tissues and in the peripheral blood (Dahlenbach-Hellweg, 1975;Bonatz et al, 1992;Kamat and Isaacson, 1987;Laguens et al, 1990;Morris et al, 1985;Loke and King, 1995). Although the precise function of these cells in the female reproductive tract remains to be established, a role in surveillance against aberrant trophoblast proliferation and uterine invasion has been proposed (King et al, 1996).…”

Section: Cells Of the Immune System In The Female Reproductive Tractmentioning

confidence: 97%

Mucosal Immunity in the Human Female Reproductive Tract

et al. 2015

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“…En otro importante sector del NOA, en el valle del Cajón, se lograron resolver los conflictos internos configurándose una mayor aglomeración e integración, aunque prevaleciendo lo doméstico como el eje de relación. Por el contrario, en otros sectores más meridionales como Hualfín y Ambato, las decisiones y resoluciones de problemas fueron llevadas a cabo en ámbitos específicos comunales bajo la coordinación de personajes especializados que mediante la herencia obtenían el poder (Pérez Gollán 1992; Laguens 2004Laguens y 2006Gordillo 2004Gordillo y 2007.…”

Section: Cultos a Los Ancestros Entre Los Pueblos De Los Andes Meridiunclassified

“…De esta manera, si se encuentran pruebas de desigualdad en el acceso a determinados recursos, es posible sostener la existencia de un clima de complejidad (Pérez Gollán 2000; Tartusi y Núñez Regueiro 2001). Problemáticas con enfoques individualistas y basados en el estudio de la exclusión social se han destacado dentro de las preguntas planteadas proponiendo un traspaso a mediados del primer milenio de esta era, de «aldeas igualitarias» y «simples» a «jefaturas» o «nuevas formas de organización social más complejas y diferenciadas» (Pérez Gollán 1992; Laguens 2004).…”

Section: Introductionunclassified

Autonomía doméstica en un mundo complejo (Valle de Tafí, Argentina)

Salvi¹

2018

BOLARQ

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Una sociedad sin relaciones de poder es tan solo una abstracción (Foucault 1983) Resumen El presente artículo se centra en discutir las estrategias de reproducción social puestas en acción para el mantenimiento de la autonomía doméstica durante casi un milenio en el valle de Tafí. El énfasis está puesto en expandir los argumentos explicativos acerca de los motivos, los factores y las relaciones que llevaron a que una población perpetuara relaciones políticas no jerárquicas, basadas en colectivos de pequeña escala amalgamados por vínculos de parentesco. Para fundamentar esta propuesta el eje se basa en el estudio del rol que jugaron los ancestros en la reproducción de la autonomía, enfatizando los tipos de interacción social que las expresiones materiales de los ancestros habilitaron, organizaron, promovieron, reforzaron y fomentaron. Luego se describen dos escenarios con ancestros venerados: los montículos y las áreas residenciales, poniendo especial atención en los patios y en la presencia de esculturas de piedra, como en los sepulcros o cistas.

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Demonstration and characterization of HLA-DR positive cells in the stroma of human endometrium

Cited by 16 publications

References 6 publications

Detection of Intraepithelial and Stromal Langerin and CCR5 Positive Cells in the Human Endometrium: Potential Targets for HIV Infection

Detection of Intraepithelial and Stromal Langerin and CCR5 Positive Cells in the Human Endometrium: Potential Targets for HIV Infection

Mucosal Immunity in the Human Female Reproductive Tract

Autonomía doméstica en un mundo complejo (Valle de Tafí, Argentina)

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