2009
DOI: 10.1016/j.jinorgbio.2009.07.023
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Demonstration of aluminum in amyloid fibers in the cores of senile plaques in the brains of patients with Alzheimer’s disease

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Cited by 150 publications
(93 citation statements)
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“…demonstrated that Al was colocalized with Aβ in amyloid fibers in the cores of SPs 16) . Other studies have also shown that Al increased the level of Aβ, promoted Aβ aggregation, and increased Aβ neurotoxicity 10,17) .…”
Section: Introductionmentioning
confidence: 96%
“…demonstrated that Al was colocalized with Aβ in amyloid fibers in the cores of SPs 16) . Other studies have also shown that Al increased the level of Aβ, promoted Aβ aggregation, and increased Aβ neurotoxicity 10,17) .…”
Section: Introductionmentioning
confidence: 96%
“…The levels of Cu 2ϩ , Zn 2ϩ , and Fe 3ϩ in the AD neuropil are also significantly elevated (19), where Zn 2ϩ is elevated from 346 to 786 M, Cu 2ϩ from 69 to 304 M, and Fe 3ϩ from 338 to 695 M (19,20). Al 3ϩ has also been detected in amyloid fibers in cores of the senile plaques (21). Moreover, the imbalance of cellular Zn 2ϩ and/or Cu 2ϩ homeostasis modulates AD pathology (22,23), and dietary Cu 2ϩ and Al 3ϩ are risk factors for AD (24 -25).…”
mentioning
confidence: 99%
“…The original description of this connection (Perl and Brody, 1980) was disputed due to the problem of obtaining accurate Al analyses and the probability of sample contamination (Bjertness et al, 1996). However, a wide range of more sophisticated analytical procedures including laser microprobe mass analysis (Bouras et al, 1997), instrumental neutron activation (Andrasi et al, 2005), an improved graphite furnace atomic absorption method (Xu et al, 1992) or energy-dispersive X-ray spectroscopy combined with transmission electron microscopy (Yumoto et al, 2009), have all basically confirmed the original findings. Laser microprobe mass analysis revealed the Al to be largely situated within the neurofibrillary tangles associated with AD (Bouras et al, 1997).…”
Section: Inflammation Is Pronounced In the Aging Brain And This Is Fmentioning
confidence: 97%