Demonstration of anti-hydralazine antibody in hydralazine inducedLupus erythematosus

Drugs Acting on Arteriolar Smooth Muscle (Vasodilator Drugs)

“…This latter phase can be avoided by the administration of antihypertensive drugs other than hydralazine. Antibodies against hydralazine have been demonstrated by means of a hemagglutinine test in the serum of one patient after prolonged treatment (FRIEDMAN and HEINE, 1963). In another study circulating antibodies to hydralazine were found in patients with active lupus erythematosus induced by the drug.…”

Induction of antibodies to nuclear antigens in rabbits by immunization with hydralazine-human serum albumin conjugates.

“…It does so in approximately 7-13% of the patients chronically treated (7,8). However, though we know the provocative agent, the possible pathogenetic mechanisms remain obscure with the sole exception that hydralazine antibodies have been reported in these patients (3,9).…”