Demonstration of Borna disease virus-specific RNA in secretions of naturally infected horses by the polymerase chain reaction

Richt, Jüergen A.; Herzog, S.; Haberzettl, Kerstin; Rott, R.

doi:10.1007/bf00191945

Cited by 50 publications

(33 citation statements)

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“…12) was positive for both BDV p24 and p40 RNA. The detection of viral RNA in swab samples has also been reported from seropositive, asymptomatic horses (38). Herzog et al (24) reported the isolation of infectious virus from swab samples and lacrimal and parotic glands of diseased horses.…”

Section: Discussionmentioning

confidence: 89%

“…In horses, antibody prevalence among healthy animals in Germany has been reported to be approximately 10%, which increases to more than 20% in areas to which the disease is endemic (24,37). Infectious virus has been reported to be incidentally isolated from nasal and lacrimal secretions as well as saliva of diseased horses, and the presence of viral RNA was reported in these secretions in asymptomatic, antibody-positive horses (24,38). In some stables repeated outbreaks of BD are seen over several years, and sometimes numerous animals in one stable develop BD within a period of months (10,33).…”

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confidence: 99%

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Persistence of Borna Disease Virus in Naturally Infected Sheep

Vahlenkamp

Konrath

Weber

et al. 2002

J Virol

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Section: Discussionmentioning

confidence: 89%

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confidence: 99%

Persistence of Borna Disease Virus in Naturally Infected Sheep

Vahlenkamp

Konrath

Weber

et al. 2002

J Virol

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“…In naturally BDV-infected horses however, the presence of BDV-specific RNA has been demonstrated by a similar technique in brain tissue [9], and in conjunctival fluid, nasal secretions and saliva [10]. In addition, many seropositive samples from horses were negative by RT-PCR [10], indicating either that BDV is shed irregularly and in intervals or that the BDV genome is sufficiently variable in a number of seropositive animals to evade detection by this technique.…”

Section: Introductionmentioning

confidence: 99%

Demonstration of human Borna disease virus RNA in human peripheral blood mononuclear cells

et al. 1995

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BDV naturally infects horses and sheep, and causes sporadic neurological disease. Serological evidence suggests an association of BDV, or a related virus, with specific psychiatric diseases in humans. Here, by using a nested RT-PCR technique, we demonstrate that human BDV RNA is present in the PBMC of psychiatric patients. In an examination of a total of 60 patients from 5 wards of a hospital in Japan, the detection rate differed within each ward, ranging from 8% to > 50% (37% on the average). Of particular note was the finding that the human derived BDV sequences, which included deleted forms in about 23% of the positive samples, were slightly different from those derived from horse BDV. These results suggest urgent consideration of the measures to be taken to cope with the effects of blood transfusion. In addition, the detection of a high level of BDV in the PBMC of patients will help our understanding of the pathogenesis in the disease.

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“…BDV is probably shed in nasal, salivary and 132 G. Dauphin et al conjunctival secretions since BDV-RNA has been detected in these secretions [31,50]. An olfactory route of transmission from horse to horse has been proposed (via the olfactive nerve), either by direct contact with these secretions, or through contaminated food or water.…”

Section: Transmissionmentioning

confidence: 99%

Borna disease: current knowledge and virus detection in France

Dauphin¹,

Legay

Pitel

et al. 2002

Vet. Res.

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-For over two centuries, Borna disease (BD) has been described as a sporadically occurring infectious meningoencephalomyelitis affecting horses and sheep in Central Europe. Over the last decade, the BD epidemiology has been discussed. Firstly, its geographical distribution seems larger than what was previously thought. Secondly, the disease can affect a large number of warm-blooded animal species, including humans. The aetiological agent is the Borna disease virus (BDV), an enveloped, nonsegmented negative-stranded RNA virus classified in the new virus family Bornaviridae (Mononegavirales order). It can induce severe clinical signs of encephalitis with striking behavioural disturbances and may cause death. BDV genome has recently been detected in France in the blood and brain of several animal species (horses, bovines, foxes). meningoencephalomyelitis / Borna disease virus / epidemiology / diagnosisRésumé -La maladie de Borna : connaissances actuelles et détection du virus en France. La maladie de Borna est connue depuis plus de deux siècles en Europe centrale comme une méningoencé-phalomyélite d'origine infectieuse affectant les chevaux et les moutons. Depuis ces dix dernières années, l'épidémiologie de la maladie a été révisée puisque la répartition géographique de la maladie de Borna s'avère plus large que rapportée jusqu'alors. En outre, elle peut affecter un grand nombre d'espèces animales à sang chaud, y compris l'homme. L'agent étiologique est le BDV (virus de la maladie de Borna), virus enveloppé, à ARN simple brin, non segmenté et de polarité négative, récem-ment classifié dans la nouvelle famille des Bornaviridae, (ordre des Mononegavirales). Le BDV peut induire des signes cliniques sévères d'encéphalite virale avec des troubles comportementaux importants et il peut entraîner la mort de l'animal. Récemment, le génome du BDV a été mis en évidence en France dans le sang et le cerveau de plusieurs espèces animales (chevaux, bovins, renards). méningoencéphalomyélite / virus de la maladie de Borna / épidémiologie / diagnostic 127

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Demonstration of Borna disease virus-specific RNA in secretions of naturally infected horses by the polymerase chain reaction

Cited by 50 publications

References 18 publications

Persistence of Borna Disease Virus in Naturally Infected Sheep

Persistence of Borna Disease Virus in Naturally Infected Sheep

Demonstration of human Borna disease virus RNA in human peripheral blood mononuclear cells

Borna disease: current knowledge and virus detection in France

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