Demonstration of candida in blood smears.

Candida albicans blastoconidia in peripheral blood smears from non-neutropenic surgical patients.

“…[2][3][4][5][6][7][8] Most reports describe patients with [5][6][7] Interestingly, C albicans was the species involved in all these cases. In line with these findings, our patient was admitted because of an intestinal obstruction, a necrotising process having already begun at the time of surgery.…”

“…However, in other reports, fungi were also phagocytosed, either by neutrophils in the case of Candida sp and P marn-eVei, or by monocytes in the case of Histoplasma sp, Cryptococcus sp, and P marneVei. [2][3][4][5][6][7][8] Moreover, in candida infected tissues, the neutrophils are the primary inflammatory cell seen and microabscesses are common. Thus in the case described here leucoagglutination was probably the actual host response to fungal invasion and not a laboratory artefact.…”

“…However, even when the yeast load is high, blood cultures do not yield C albicans before a minimum of two days (range two to five). [5][6][7][8] Thus leucoagglutination should prompt pathologists to look for yeasts and pseudohyphae in blood smears of patients at risk, such those with severe intestinal lesions. …”

“…1 In addition, various fungal infections have been diagnosed by direct detection of fungi in peripheral blood smears. [2][3][4][5][6][7][8] Most patients were immunocompromised. We report here the detection of Candida albicans in a blood smear from a surgical patient.…”

Effect of pathogenic yeasts on human platelet aggregation

“…In addition, pathogenic fungi, like the yeasts Candida albicans and Cryptococus neoformans, can cause infections that are particularly severe in immunocompromised individuals [11,12]. During fungal infection, these patients are under increased risk for fungal proliferation in their blood and further vascular dissemination [13,14].…”