Demonstration of defective C3-receptor-mediated clearance by the reticuloendothelial system in patients with acquired immunodeficiency syndrome.

Bender, Bradley S.; Bohnsack, John F.; Sourlis, S H; Frank, Michael M.; Quinn, Thomas C.

doi:10.1172/jci112876

Cited by 41 publications

(22 citation statements)

References 32 publications

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“…In contrast, in vitro infection of monocyte-derived M with HIV-1 caused downregulation of CD11b (34,43). In addition, it was demonstrated that in vivo there is impaired CR3-mediated clearance of 51 Cr-labeled iC3b-coated autologous erythrocytes (44). These investigators also found normal levels of CD11b on HIVϩ patient monocytes, and, therefore, suggested that there is an impairment of M phagocytosis.…”

Section: Discussionmentioning

confidence: 99%

Modulation of the effector function of human macrophages for Histoplasma capsulatum by HIV-1. Role of the envelope glycoprotein gp120.

Chaturvedi

Newman²

1997

J. Clin. Invest.

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We have demonstrated that monocyte-derived macrophages (M ) from HIV ϩ individuals are deficient in their capacity to phagocytose Histoplasma capsulatum (Hc) yeasts, and are more permissive for the intracellular growth of Hc. To determine whether these defects in M function were caused by HIV infection of the M and/or by pathological events associated with HIV infection, cultured normal human M were infected with the HIV-1 BaL strain. Virus production, quantified by reverse transcriptase activity and p24 antigen, was evident on day 8 after infection and peaked on day 16. On days 12, 16, and 20 after infection, HIV-1-infected M were deficient in their capacity to recognize and bind Hc yeasts compared with control M , and also were more permissive for the intracellular growth of Hc. Culture of normal M with the envelope glycoprotein gp120 inhibited phagocytosis of Hc yeasts by M in a concentration-dependent manner, but did not cause more rapid intracellular growth of Hc. Normal M cultured in the serum of HIV ϩ individuals with impaired M function subsequently were deficient in their capacity to phagocytose Hc yeasts, and were more permissive for the intracellular growth of yeasts compared with M cultured in normal serum. Conversely, culture of normal M in the serum of HIV ϩ patients with normal M function did not affect the interaction of Hc yeasts with M . Moreover, when M from HIV ϩ individuals that were initially defective in host defense against Hc were cultured in normal HIV Ϫ serum, normal M function was demonstrated. Adsorption of gp120 from the serum of two HIV ϩ patients removed the capacity of the serum to cause a M defect in phagocytosis of Hc, but had no effect on the capacity of the serum to cause accelerated intracellular growth. These data demonstrate that observed defects in M interaction with Hc yeasts may be caused by gp120 and other, as yet unknown serum component(s) probably released into serum by HIV-infected cells. (

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Section: Discussionmentioning

confidence: 99%

Modulation of the effector function of human macrophages for Histoplasma capsulatum by HIV-1. Role of the envelope glycoprotein gp120.

Chaturvedi

Newman²

1997

J. Clin. Invest.

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“…These data too hint at previous exposure of phagocytes to IFN-7 challenge in vivo. Several other phenotypic and functional features of I FN-y-lreated phagocytes, such as low surface CD4 antigen levels [21], decreased C3-reccptor function [22], increased spontaneous and antibody-dependent cytotoxicity [20], have been observed in untreated phagocytes from HIV patients [23][24][25][26]. further suggesting a priming effect of circulating IFN-}' on these cells.…”

Section: Discussionmentioning

confidence: 99%

Increased expression of IgG Fc receptor type I on neutrophils and monocytes from HIV-infected subjects

Capsoni

Minonzio

Ongari

et al. 1992

Clinical and Experimental Immunology

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SUMMARYInterferon-gamma (IFN-y) induces de novo expression of IgG Fc receptor type T (FcRI) on neutrophils and significantly raises the level of these receptors on monocyics. Since increased concentrations of IFN-y have been observed in sera from patients with HIV infection, FcRI expression might also be increased on these subjects" phagocytes. FcRI expression was assessed by indirect immunofluorescencc staining of phagocytes in whole blood from 40 healthy controls and 55 HIV ' subjects. 24 belonging to CDC class III and 31 to CDC class IV; 42 were intravenous drug abusers (IVDA) and 13 were homosexual men. Plasma levels of IhN-y were measured using a modified immunoradiometric assay. The mean linear fluorescence intensity., used as a relative measure of receptor expression, was significantly higher on unseparated neutrophils from HIVŝ ubjects in CDC classes III (/*< 0001) and IV (P< 0 0001) than from controls. Similar changes in FcRI expression were observed on monocytes from HIV' subjects. While no differences were observed between IVDA and homosexual HIV' patients, there was a significant association between FcRI expression and the patients' CDC stage, those in class IV having the highest FcRI levels. Plasma IFN-y concentrations were significantly higher in HIV*^ patients than in controls and a positive correlation with the stages of HIV infection was again observed. FcRI expression was aiso increased on freshly purified neutrophils from five HIV * patients in CDC class IV but did not increase further after 18 h incubation with IFN--/. a treatment that up-regulated FeRI expression on control neutrophils. These data suggest that: (i) FcRI evaluation may be a sensitive marker for the biological activity of IFN-y in vivo: (ii) phagocytes from HIV * subjects are activated in vivo by IFN-y. expressing increased levels of FcRI; (iii) these IFN-y-activated cells may play a role in the pathogenesis of AIDS.

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“…It may be that a reduced immunologic response due to the immune deficit in HIV-1-infected patients tor [23], that would give rise to decreases in phagocytosis [24,25]; in myeloperoxidase activity [26] with associated decreases spares the brain from the inflammatory alterations that are produced in the initial phases of meningitis and are directly in bacterial lytic activity; and in antibody-mediated cytotoxic activity have been described among HIV-1-infected patients related to mortality. [27].…”

Section: Patients Infected With Hiv-1 Have a Primary Defect In Cellu-mentioning

confidence: 99%

Favorable Prognosis of Purulent Meningitis in Patients Infected with Human Immunodeficiency Virus

Almirante¹,

Saballs²,

Ribera³

et al. 1998

CLIN INFECT DIS

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We prospectively reviewed all cases of purulent meningitis among human immunodeficiency virus (HIV) type 1 -infected patients ú14 years old that occurred at the Hospital General Vall d'Hebron (Barcelona) during the period 1 January 1985 through 31 March 1997. There were 12 episodes of purulent meningitis in nine of 2,150 HIV-1-infected patients. The annual rate of purulent meningitis was 0.465 cases per 1,000 patients, a rate that is 150 times higher than that for the general population. During 10 episodes, CD4/ lymphocyte counts were õ200/mm 3 . The etiologic organism was Streptococcus pneumoniae in nine episodes (seven episodes occurred in four splenectomized patients), and Escherichia coli, Streptococcus agalactiae, and Enterococcus faecium each caused one episode. Clinical features and cerebrospinal fluid abnormalities were similar to those observed among patients without HIV-1 infection. All patients had bacteremia. The overall mortality was 8.3%. We conclude that purulent meningitis, particularly pneumococcal meningitis, is more frequent among HIV-1-infected patients than in the general population. The prognosis for HIV-1-infected patients is better than for HIV-1-negative patients.

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Demonstration of defective C3-receptor-mediated clearance by the reticuloendothelial system in patients with acquired immunodeficiency syndrome.

Abstract: The function of macrophage C3

Cited by 41 publications

References 32 publications

Modulation of the effector function of human macrophages for Histoplasma capsulatum by HIV-1. Role of the envelope glycoprotein gp120.

Modulation of the effector function of human macrophages for Histoplasma capsulatum by HIV-1. Role of the envelope glycoprotein gp120.

Increased expression of IgG Fc receptor type I on neutrophils and monocytes from HIV-infected subjects

Favorable Prognosis of Purulent Meningitis in Patients Infected with Human Immunodeficiency Virus

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