Demonstration of “Owl’s Eye” Morphology by Confocal Microscopy in a Patient With Presumed Cytomegalovirus Corneal Endotheliitis

The validity of clinical feature profiles for cytomegaloviral anterior segment infection

“…One is corneal endotheliitis [5,6,10,[19][20][21] and the other is anterior uveitis [3,7,8,22,23]. In the reports of patients with CMV anterior uveitis, high IOP was one of the clinical manifestations [7,8,21].…”

Cytomegalovirus-associated anterior segment infection

“…However, various concentrations of ganciclovir eye drops have also been used in the literature for the treatment of CMV anterior uveitis [18,20,21].…”

“…1 Topical ganciclovir 0.5% eight-times daily and intravenous ganciclovir 500 mg/day for 2 weeks followed by topical ganciclovir 0.5% four-times daily for 3 months Responded 3 [20] Shimazaki et al…”

“…Owl's eyes lesions were seen in two eyes: one on confocal microscopy [20] and one on histology [21]. These owl's eye lesions consist of intranuclear inclusion bodies, and are characteristic of CMV infection [25].…”

“…During the same period, 51 eyes of 48 patients with CMV endotheliitis (Figure 3) were analyzed, and all were from Asian populations [6,8,[16][17][18][19][20][21][22][23][24]. Unlike eyes with anterior uveitis, the KPs in eyes with corneal endotheliitis tended to be pigmented, and were often arranged in a linear or coin-shaped pattern (Table 2).…”