Demonstration of the effectiveness of zinc in diarrhoea of children living in Switzerland

Crisinel, Pierre Alex; Verga, Marie-Elise; Kouame, Konan Sallert Alexis; Pittet, Anne; Rey-Bellet, Céline Gasser; Fontaine, Olivier; Paolo, Ermindo R. Di; Gehri, Mario

doi:10.1007/s00431-015-2512-x

Cited by 21 publications

(31 citation statements)

References 15 publications

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“…A meta-analysis (including 18 clinical trials with 6165 participants) showed that zinc supplementation resulted in a shorter diarrhea duration in acute diarrhea, and less diarrhea at Day 3 and Day 5, similar to our results (17). In contrast to other studies, a recently made double-blind randomized study about zinc supplementation for acute diarrhea in Switzerland showed that zinc treatment decreases the frequency and severity of diarrhea in children aged 2 months to 5 years old, but not the duration of diarrhea (20). In developing countries, zinc supplementation might be useful in the treatment of acute diarrhea for children older than 6 months.…”

Section: Discussionsupporting

confidence: 88%

Effects of zinc or synbiotic on the duration of diarrhea in children with acute infectious diarrhea

Yazar

Güven²,

Dinleyici³

2020

Turk J Gastroenterol

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Section: Discussionsupporting

confidence: 88%

Effects of zinc or synbiotic on the duration of diarrhea in children with acute infectious diarrhea

Yazar

Güven²,

Dinleyici³

2020

Turk J Gastroenterol

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“…Seventeen trials only enrolled children over six months of age (Sachdev 1988; Sachdev 1990; Sazawal 1995; Bhutta 1999; Faruque 1999; Penny 1999; Khatun 2001; Bahl 2002; Strand 2002; Boran 2006; Roy 2008a; Fajolu 2008; Patel 2009; Dutta 2011; Karamyyar 2013; Passariello 2015; Tran 2015). Fourteen trials included children of different ages greater than one month (Roy 1997; Roy 1998; Dutta 2000; Al-Sonboli 2003; Polat 2003; Bhatnagar 2004a; Larson 2005; Shimelis 2008; Patro 2010; Dalgic 2011; Jin 2013; Crisinel 2015; Patel 2015; Jiang 2016). …”

Section: Resultsmentioning

confidence: 99%

“…Only three trials were conducted in Europe (Patro 2010; Crisinel 2015; Passariello 2015), two in South America (Al-Sonboli 2003; Penny 1999), two in Africa (Fajolu 2008; Shimelis 2008), one multicentre trial in Asia and Africa (Fischer Walker 2006), and one trial in Australia (Tran 2015). Thus, participants were from Bangladesh (Roy 1997; Roy 1998; Faruque 1999; Khatun 2001; Brooks 2005a; Larson 2005; Roy 2008a), India (Sachdev 1988; Sachdev 1990; Sazawal 1995; Dutta 2000; Bahl 2002; Bhatnagar 2004a; Fischer Walker 2006 IND; Patel 2009; Patel 2015), Pakistan (Bhutta 1999; Fischer Walker 2006 PAK), Nepal (Strand 2002), China (Jin 2013; Jiang 2016), Turkey (Polat 2003; Boran 2006; Dalgic 2011), Brazil (Al-Sonboli 2003), Peru (Penny 1999), Ethiopia (Fischer Walker 2006 ETH; Shimelis 2008), Nigeria (Fajolu 2008), Poland (Patro 2010), Italy (Passariello 2015), Switzerland (Crisinel 2015), and Australia (Tran 2015). …”

Section: Resultsmentioning

confidence: 99%

“…Nine trials were conducted in countries at medium risk: Nepal (Strand 2002); Turkey (Polat 2003; Boran 2006, Dalgic 2011); Brazil (Al-Sonboli 2003), China (Jin 2013), Iran (Karamyyar 2013), Nigeria (Fajolu 2008), and Ethiopia (Shimelis 2008). Four trials were conducted in countries where zinc deficiency is considered rare: Poland (Patro 2010), Italy (Passariello 2015), Switzerland (Crisinel 2015), and Australia (Tran 2015).…”

Section: Resultsmentioning

confidence: 99%

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Oral zinc for treating diarrhoea in children

Lazzerini

Wanzira

2016

Cochrane Database of Systematic Reviews

172

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Background In developing countries, diarrhoea causes around 500,000 child deaths annually. Zinc supplementation during acute diarrhoea is currently recommended by the World Health Organization (WHO) and the United Nations Children's Fund (UNICEF). Objectives To evaluate oral zinc supplementation for treating children with acute or persistent diarrhoea. Search methods We searched the Cochrane Infectious Diseases Group Specialized Register, CENTRAL (the Cochrane Library 2016, Issue 5), MEDLINE, Embase, LILACS, CINAHL, m RCT, and reference lists up to 30 September 2016. We also contacted researchers. Selection criteria Randomized controlled trials (RCTs) that compared oral zinc supplementation with placebo in children aged one month to five years with acute or persistent diarrhoea, including dysentery. Data collection and analysis Both review authors assessed trial eligibility and risk of bias, extracted and analysed data, and drafted the review. The primary outcomes were diarrhoea duration and severity. We summarized dichotomous outcomes using risk ratios (RR) and continuous outcomes using mean differences (MD) with 95% confidence intervals (CI). Where appropriate, we combined data in meta‐analyses (using either a fixed‐effect or random‐effects model) and assessed heterogeneity. We assessed the certainty of the evidence using the GRADE approach. Main results Thirty‐three trials that included 10,841 children met our inclusion criteria. Most included trials were conducted in Asian countries that were at high risk of zinc deficiency. Acute diarrhoea There is currently not enough evidence from well‐conducted RCTs to be able to say whether zinc supplementation during acute diarrhoea reduces death or number of children hospitalized ( very low certainty evidence ). In children older than six months of age, zinc supplementation may shorten the average duration of diarrhoea by around half a day (MD −11.46 hours, 95% CI −19.72 to −3.19; 2581 children, 9 trials, low certainty evidence ), and probably reduces the number of children whose diarrhoea persists until day seven (RR 0.73, 95% CI 0.61 to 0.88; 3865 children, 6 trials, moderate certainty evidence ). In children with signs of malnutrition the effect appears greater, reducing the duration of diarrhoea by around a day (MD −26.39 hours, 95% CI −36.54 to −16.23; 419 children, 5 trials, high certainty evidence ). Conversely, in children younger than six months of age, the available evidence suggests zinc supplementation may have no effect on the mean duration of diarrhoea (MD 5.23 hours, 95% CI −4.00 to 14.45; 1334 children, 2 trials, low certainty evidence ), or the num...

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“…The authors made no comment with regard to funding or potential bias. Despite having identical treatment arms, Crisinel et al ’s11 2015 study of 87 children aged between 2 and 60 months in one hospital in Switzerland elicited different results. Per-protocol analysis showed significantly shorter median duration of diarrhoea in the zinc arm.…”

Section: Commentarymentioning

confidence: 99%

Question 1: Does zinc enhance recovery time from gastroenteritis in high-income countries?

Creasy

Stebbings

2017

Arch Dis Child

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Demonstration of the effectiveness of zinc in diarrhoea of children living in Switzerland

Cited by 21 publications

References 15 publications

Effects of zinc or synbiotic on the duration of diarrhea in children with acute infectious diarrhea

Effects of zinc or synbiotic on the duration of diarrhea in children with acute infectious diarrhea

Oral zinc for treating diarrhoea in children

Question 1: Does zinc enhance recovery time from gastroenteritis in high-income countries?

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