Demonstration of the utility of biomarkers for dietary intake assessment; proline betaine as an example

Abstract

Publication informationproline betaine was quantified and normalized to osmolality. Calibration curves were 8 developed and used to predict citrus intake in an independent cohort; the Irish National Adult 9

Ingestion of an Inulin‐Enriched Pork Sausage Product Positively Modulates the Gut Microbiome and Metabolome of Healthy Rats

“…These findings likely reflect the higher level of carbohydrates and differences in the composition of carbohydrates of these diets. Thus, these data are consistent with numerous previous studies showing that NMR‐based metabolomics is a very efficient tool for the detection and identification of dietary exposure markers . However, no strong association between these monosaccharides and the impact on the endogenous metabolic response to intake of meat is anticipated.…”

Nutrimetabolomics: An Integrative Action for Metabolomic Analyses in Human Nutritional Studies

“…Next to the question of sensitivity and selectivity of a marker metabolite, a key question for food intake assessment is whether food metabolomic applications will be able to provide quantitative information on the amount of the food consumed. Studies published recently have provided the first evidence that quantification appears feasible with proline‐betaine as a key compound for citrus intake or anserine and methyl‐histidines for estimation of chicken meat consumption . Another important question is whether metabolite signatures can serve as a surrogate of a diet style; first studies suggest that this may be possible .…”

Metabolomic‐Based Approach to Identify Biomarkers of Apple Intake

“…[ 19 ] Recent studies by Gibbons et al. [ 20 ] in citrus fruit, Yin et al. [ 43 ] in chicken intake, and Garcia‐Perez et al.…”

“…[ 19 ] Furthermore, recent work has demonstrated the utility of biomarkers: proline betaine was used to determine intake of citrus fruit in a cross‐sectional study using calibration curves developed in a well‐controlled intervention study. [ 20 ]…”