Whispering gallery mode (WGM) cavities formed by dielectric structures have attracted intensive interest in various fields. The high-quality factor and smaller mode volume associated with the optical modes have inspired experiments in nonlinear optics, nanophotonics, and quantum information science. Moreover, it also gives rise to optical biosensors and other significant applications. To further reduce the material loss of the resonator, optical gain materials, such as erbium and ytterbium, are doped into the dielectric structure to increase the nonlinear effect and enhance the interaction between light and matter. Here in this review, we outline the most recent advancements in gain-doped optical WGM microcavities. Moreover, we introduce the dynamics of the gain in WGM resonators, the integration of gain media into WGM microcavities with various shapes, and the fabrication and applications of the gain microcavities. Also, the applications of the gain cavity based on the whispering-gallery mode have been introduced, e.g., ultra-sensitive sensors, low-threshold lasers, and high-performance optical systems.