Demonstration von Fetalem Hamoglobin in den Erythrocyten Eines Blutausstrichs

Kleihauer, E.; Braun, H.; Betke, Klaus

doi:10.1007/978-94-011-6138-1_22

Cited by 107 publications

(117 citation statements)

References 0 publications

Supporting

Mentioning

109

Contrasting

Unclassified

Order By: Relevance

“…Significant feto-maternal bleed can lead to severe anemia as seen in our patient and often may lead to fetal death in utero. The diagnosis of a feto-maternal bleed can be made by a simple bedside test known as the Kleihauer-Betke (KB) test [5]. In this case, the KB test obtained within 1 hour of delivery, showed a fetal cell count of 90 in 2000, representing 150 ml fetal blood which explains the severe anemia seen in this patient.…”

Section: Issn: 2380-0534mentioning

confidence: 86%

Silent Feto-Maternal Bleed as a Cause of Severe Neonatal Anemia

2016

J Paediatr Child Care

View full text Add to dashboard Cite

Feto-maternal bleed is a common presentation during pregnancy that may have adverse consequences on the perinatal clinical course of the infant and mother alike. Anemia is a common presentation of an infant secondary to feto-maternal bleed. Large volume feto-maternal bleeds may lead to severe neonatal anemia in the absence of obvious maternal symptoms. Hence, a high index of suspicion must be maintained in the absence of other obvious causes of neonatal anemia. We describe a case of an infant with severe anemia secondary to a silent feto-maternal bleed associated with a normal appearing placenta on examination and the absence of obvious maternal symptoms.sepsis. Transcutaneous bilirubin was measured at 0.8 mg/dl and later a serum bilirubin showed an unconjugated bilirubin of 0.5 mg/dl and conjugated bilirubin of 0.0 mg/dl. On physical exam, baby had a normal anterior fontanelle without any signs of bulging and a soft non-distended, non-tender abdomen with normal bowel sounds. 20 ml/kg of packed red blood cells was emergently transfused. Blood was transfused over 4 hours in 2 aliquots without any complications. CBC post transfusion showed a Hgb of 10.9 g/dl and a Hct of 31.6%, The heart murmur was no longer audible post transfusion. The baby continued to be hemodynamically stable post transfusion. Hemoglobin electrophoresis was sent and it returned normal results. Further maternal history and an additional bedside test revealed the diagnosis.

show abstract

Section: Issn: 2380-0534mentioning

confidence: 86%

Silent Feto-Maternal Bleed as a Cause of Severe Neonatal Anemia

2016

J Paediatr Child Care

View full text Add to dashboard Cite

show abstract

“…Occult blood loss prior to birth is seen in the twin transfusion syndrome or may be caused by bleeding of the fetus into the maternal circulation. WEINER [17] had suggested the existence of this latter entity for the first time, but it was not until the introduction by KLEIHAUER and BETKE [4] of the acid elution technique that the occurrence of feto-maternal hemorrhage could be demonstrated. In approximately 50 % of all pregnancies a small number of fetal cells penetrate the maternal circulation whereas in 1 % the larger number of fetal cells suggest a massive transfusion exceeding 40ml [1], The reason for such a transfusion of fetal red cells into the maternal circulation remains J. Perinat.…”

Section: Discussionmentioning

confidence: 99%

Severe neonatal anemia possibly caused by spontaneous cephalic version, with excellent outcome — a case report

Franckx¹,

Sacré-Smits²

1984

Journal of Perinatal Medicine

View full text Add to dashboard Cite

“…A separate study had shown a close similarity between the results of paired determinations of HbF by radial immunodiffusion and densitometry over the whole range of sensitivity of the methods (r = 0.9261; P < 0.001; n = 62 pairs). The red blood cell (RBC) distribution of HbF was assessed microscopically after acid elution according to the method of Kleihauer et al 10 Hemoglobin A2% (HbA 2 ) was determined by densitometry on cellulose acetate electrophoretic strips, which was convenient to use and compared closely with DEAE microcolumn chromatography, a reference method for HbA 2 determination (r = 0.81; P < 0.001; n = 68 pairs).…”

Section: Methodsmentioning

confidence: 99%

Regional Variations in Sickle Cell Anemia in Saudi Arabia

et al. 1988

View full text Add to dashboard Cite

We examined mean corpuscular volume (MCV), fetal hemoglobin (HbF) levels, and severity of clinical disease in 81 patients with sickle cell anemia from various regions of Saudi Arabia. We found that patients from eastern Saudi Arabia had less severe symptoms, higher mean Hb levels, and lower MCV than patients from other regions. Using a severity index, calculated as the mean value of individual symptoms and physical signs in patients in each region, we found that less severe symptoms were associated with lower MCV. High HbF levels were not confined to Eastern Province patients but were seen in other regions. There was a statistically significant inverse correlation between HbF% and the severity index. We also found that only two of the 24 minimally symptomatic patients had an HbF level less than 18%, whereas among the 57 severely symptomatic patients, 14 (25%) had an HbF level less than 18%, confirming the protective value of a certain minimum level of HbF.

show abstract

Demonstration von Fetalem Hamoglobin in den Erythrocyten Eines Blutausstrichs

Cited by 107 publications

References 0 publications

Silent Feto-Maternal Bleed as a Cause of Severe Neonatal Anemia

Silent Feto-Maternal Bleed as a Cause of Severe Neonatal Anemia

Severe neonatal anemia possibly caused by spontaneous cephalic version, with excellent outcome — a case report

Regional Variations in Sickle Cell Anemia in Saudi Arabia

Contact Info

Product

Resources

About