:
Neurological diseases expose individuals to a higher risk of suicidal ideation and suicidal behavior, including
completed suicides and suicide attempts. They also represent a paradigmatic arena to study the etio-pathogenic mechanisms
underlying suicidality because they are emblematic of the heterogeneity and complexity of mutual interrelationships characterizing this issue. On the one hand, neurological diseases imply strictly biological impairments that are postulated to be the
basis of vulnerability to suicide or result in the need for treatments for which a suicidal risk has been hypothesized. On the
other hand, they question some subjective experiences of neurological patients, up to near existential positions. Often, in
fact, they are accompanied by severe hopelessness. The latter may originate in, particularly for the most severe neurological
diseases, the absence of curative treatments, unpredictable disease progression that leads to acute relapses or chronicity, a
decrease of autonomy or self-identity, progressive social isolation, a sense of becoming useless, and a perception of feeling
stigmatized. This may ultimately cause a slip into the experience of an absurd condition. At the confluence of neurobiology
and hopelessness, frequent psychiatric co-morbidities may play a primary role. To conclude, neurological patients require
special attention from clinicians which should consist of openly verbalizing and exploring the suicidal thematic, inquiring
about protective and risk factors, and promptly initiating both a psychopharmacological treatment and, where possible, psychological support.