Demyelinating evidences in CMS rat model of depression: A DTI study at 7T

Kumar, B.S. Hemanth; Mishra, Sushanta Kumar; Trivedi, Richa; Singh, Sadhana; Rana, Poonam; Khushu, Subash

doi:10.1016/j.neuroscience.2014.05.037

Cited by 42 publications

(29 citation statements)

References 43 publications

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“…No significant group differences were found in the post-stress FA values of any of the hippocampal ROIs examined, nor were any significant correlations between SI ratios and pre-stress, post-stress or longitudinal changes in FA values observed, which is consistent with previous negative results (Delgado y Palacios et al, 2011; Kumar et al, 2014; Khan et al, 2016). However, Anacker et al (2016), with an ex vivo MRI method, revealed that the hippocampal FA value of CSDS mice were positively correlated with their social avoidance index, suggesting that water diffusion is more anisotropic in stress-susceptible mice.…”

Section: Discussionsupporting

confidence: 91%

“…The FA value reflects cell number, tissue density, and cell structure alignment; therefore, this pre-existing lower FA value may result from an inconsistent orientation, reduced cell structure alignment, decreased myelination or increased interference from neuroinflammation, gliosis or other factors that limit the diffusion of water molecules in the right vHi of the susceptible mice (Beppu et al, 2005; Alexander et al, 2007; Kinoshita et al, 2008; Evans, 2013; Kumar et al, 2014; Anacker et al, 2016). Concerning cellular changes have been demonstrated postmortem in the hippocampus of major depressive disorder (MDD) (Stockmeier et al, 2004) and PTSD patients (Krystal and Duman, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…For example, in healthy individuals, people with higher education (Piras et al, 2011) or better memory function (Carlesimo et al, 2010) have been demonstrated to have a lower hippocampal MD value. Higher MD values may result from reduced membrane density and may also reflect neuronal arborization or increased extracellular space (Londono et al, 2003; Kumar et al, 2014). Meanwhile, a higher RD value in white matter is usually associated with demyelination or dysmyelination (Song et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…As a non-invasive imaging method, diffusion tensor imaging (DTI) can be repeatedly employed in longitudinal studies and is able to sensitively detect microstructural organization by measuring physical properties of water molecule diffusion in the tissue of interest (Alexander et al, 2007; Kumar et al, 2014). Among the most widely used diffusion indices, fractional anisotropy (FA) reflects the degree of tissue integrity and alignment of cellular structure (Beppu et al, 2005; Kinoshita et al, 2008; Anacker et al, 2016), while mean diffusivity (MD) is more related to cell density and size (Kumar et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Among the most widely used diffusion indices, fractional anisotropy (FA) reflects the degree of tissue integrity and alignment of cellular structure (Beppu et al, 2005; Kinoshita et al, 2008; Anacker et al, 2016), while mean diffusivity (MD) is more related to cell density and size (Kumar et al, 2014). In addition, the radial diffusivity (RD) and axial diffusivity (AD) should be considered in the interpretation of the FA value, for they represent myelin and axonal integrity, respectively, and pathological alterations in either can lead to a decrease in FA.…”

Section: Introductionmentioning

confidence: 99%

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Longitudinal in vivo Diffusion Tensor Imaging Detects Differential Microstructural Alterations in the Hippocampus of Chronic Social Defeat Stress-Susceptible and Resilient Mice

Xiao

Yuan

et al. 2018

Front. Neurosci.

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Background: Microstructural alterations in the hippocampus may underlie stress-related disorders and stress susceptibility. However, whether these alterations are pre-existing stress vulnerability biomarkers or accumulative results of chronic stress remain unclear. Moreover, examining the whole hippocampus as one unit and ignoring the possibility of a lateralized effect of stress may mask some stress effects and contribute to the heterogeneity of previous findings.Methods: After C57BL/6 mice were exposed to a 10-day chronic social defeat stress (CSDS) paradigm, different stress phenotypes, i.e., susceptible (n = 10) and resilient (n = 7) mice, were discriminated by the behavior of the mice in a social interaction test. With in vivo diffusion tensor imaging (DTI) scans that were conducted both before and after the stress paradigm, we evaluated diffusion properties in the left and right, dorsal (dHi) and ventral hippocampus (vHi) of experimental mice.Results: A significantly lower fractional anisotropy (FA) was found in the right vHi of the susceptible mice prior to the CSDS paradigm than that found in the resilient mice, suggesting that pre-existing microstructural abnormalities may result in stress susceptibility. However, no significant group differences were found in the post-stress FA values of any of the hippocampal regions of interest (ROIs). In addition, mean diffusivity (MD) and radial diffusivity (RD) values were found to be significantly greater only in the right dHi of the resilient group compared to those of the susceptible mice. Furthermore, a significant longitudinal decrease was only observed in the right dHi RD value of the susceptible mice. Moreover, the social interaction (SI) ratio was positively related to post-stress left MD, right dHi MD, and right dHi RD values and the longitudinal right dHi MD percent change. Meanwhile, a negative relationship was detected between the SI ratio and bilateral mean of the post-stress left relative to right vHi FA value, highlighting the important role of right hippocampus in stress-resilience phenotype.Conclusion: Our findings demonstrated different longitudinal microstructural alterations in the bilateral dHi and vHi between stress-susceptible and resilient subgroups and indicated a right-sided lateralized stress effect, which may be useful in the diagnosis and prevention of stress-related disorders as well as their intervention.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Longitudinal in vivo Diffusion Tensor Imaging Detects Differential Microstructural Alterations in the Hippocampus of Chronic Social Defeat Stress-Susceptible and Resilient Mice

Xiao

Yuan

et al. 2018

Front. Neurosci.

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Unraveling the mystery of white matter in depression: A translational perspective on recent advances

et al. 2022

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Background: Numerous cortical and subcortical structures have been studied extensively concerning alterations of their integrity as well as their neurotransmitters in depression. However, connections between these structures have received considerably less attention.Objective: This systematic review presents results from recent neuroimaging as well as neuropathologic studies conducted on humans and other mammals. It aims to provide evidence for impaired white matter integrity in individuals expressing a depressive phenotype.Methods: A systematic database search in accordance with the PRISMA guidelines was conducted to identify imaging and postmortem studies conducted on humans with a diagnosis of major depressive disorder, as well as on rodents and primates subjected to an animal model of depression.Results: Alterations are especially apparent in frontal gyri, as well as in structures establishing interhemispheric connectivity between frontal regions. Translational neuropathological findings point to alterations in oligodendrocyte density and morphology, as well as to alterations in the expression of genes related to myelin synthesis.An important role of early life adversities in the development of depressive symptoms and white matter alterations across species is thereby revealed. Data indicating that stress can interfere with physiological myelination patterns is presented. Altered myelination is most notably present in regions that are subject to maturation during the developmental stage of exposure to adversities. Conclusion:Translational studies point to replicable alterations in white matter integrity in subjects suffering from depression across multiple species. Impaired white matter integrity is apparent in imaging as well as neuropathological studies. Future studies should focus on determining to what extent influencing white matter integrity is able to improve symptoms of depression in animals as well as humans.

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Depression is associated with dimensional and categorical effects on white matter pathways

et al. 2018

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Demyelinating evidences in CMS rat model of depression: A DTI study at 7T

Cited by 42 publications

References 43 publications

Longitudinal in vivo Diffusion Tensor Imaging Detects Differential Microstructural Alterations in the Hippocampus of Chronic Social Defeat Stress-Susceptible and Resilient Mice

Longitudinal in vivo Diffusion Tensor Imaging Detects Differential Microstructural Alterations in the Hippocampus of Chronic Social Defeat Stress-Susceptible and Resilient Mice

Unraveling the mystery of white matter in depression: A translational perspective on recent advances

Depression is associated with dimensional and categorical effects on white matter pathways

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