The most common anatomical variation of the root canal system is a C-shaped root canal configuration and exists mostly in mandibular second molars, but may be found also in other teeth. Because of the broad spectrum of canal configurations, management of C-shaped canals is challenging for clinicians in diagnosis, shaping, cleaning and obturation. First case of c-shaped canal was documented in literature by Cooke and Cox in 1979. In this case series, we present the management of C-shaped canal configuration in mandibular second molars.