Denatured venous homograft as an arterial substitute in civilian vascular injuries. Thirty months' experience

Abstract

In the absence of suitable ASV, DSVH appears to be an interesting alternative for arterial repair in limbs in civilian vascular injuries.

Maintained Geometry, Elasticity and Contractility of Human Saphenous Vein Segments Stored in a Complex Tissue Culture Medium

“…Cryopreserved human allogenic homografts have been advised when autogenous vein is inadequate or unavailable. 12,17,18 Cryopreservation in DMSO (17.5%) with bovine serum resulted in endothelial cell blebbing, cytoplasmic vacuolisation and disruption of cell-to-cell contacts. These changes improved with implantation.…”

“…Stored human autologous or allogenic homografts are advised when no viable removable saphenous vein segments could be identified, in re-operations, 8 infected leg 13 or infected aortic 18 pathology, in certain situations in paediatric heart surgery 27 and traumatic arterial injury. 17 The common techniques used for saphenous vein storage, namely cryopreservation and cooled preservation in physiological salt solutions, 28 are far from being unproblematic. While cryopreserved arteries maintain their viscoelastic properties, 1e3,22 this is accompanied by substantial cellular damage.…”